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All accepted abstracts are available in the Journal for ImmunoTherapy of Cancer (JITC).

Abstract Titles

Poster Presentation Dates

All odd numbered posters will be presented on Wednesday, Nov. 11, from 5:15-5:45 p.m. EST and Friday, Nov. 13, from 4:40-5:10 p.m. EST. Even numbered posters will be presented on Thursday, Nov. 12, from 4:50-5:20 p.m. EST and Saturday, Nov. 14, from 1-1:30 p.m. EST.

Posters will be on display from 8 a.m. on Monday, Nov. 9, until the virtual poster hall closes on December 31, 2020.


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# Type Title Authors Category Keywords
492 Poster Presentation Integration of high dimensional datasets in an immunocompetent mammary mouse model reveals pathways of tolerance and resistance to immune checkpoint blockade Jade Moore, PhD; Lin Ma, PhD; Jian-Hua Mao, PhD; Mary Helen Barcellos-Hoff, PhD; Immune Cell Biology Checkpoint blockade; Gene expression; Immune monitoring; Inflammation; T cell; Tumor infiltrating lymphocytes (TILs); Tumor microenvironment
493 Poster Presentation Tired and Hungry: A potential role for CD47 in T cell exhaustion Chien-Huan Weng, PhD; Levi M. Mangarin, BS; Cailian Liu, MD; Roberta Zappasodi, PhD; Pamela M. Holland, PhD; Jedd D. Wolchok, MD, PhD; Taha Merghoub, PhD; David Schroder, MD; Immune Cell Biology Adoptive immunotherapy; T cell; Tumor infiltrating lymphocytes (TILs); Tumor microenvironment
494 Poster Presentation Bias in Cross-Presentation by Dendritic Cells Impacts anti-tumor T cell Responses Timothy B. Fessenden, PhD; Lauren Stopfer; Therese Cordero-Dumit; Forest White; Stefani Spranger, PhD; Immune Cell Biology Dendritic cell; Neoantigens; Tumor antigens; Vaccine
495 Poster Presentation Basal Cell Carcinoma demonstrates a T-cell exclusion immune phenotype in contrast to other anti-PD-1 therapy responsive cutaneous malignancies Geoffrey T. Gibney, MD; Joanne Xiu; Gino K. In, MD, MPH; Steven J. O'Day, MD; Jose Lutzky, MD, FACP; Joseph J. Drabick, MD, FACP, FIDSA; Ari M. VanderWalde, MD, MPH, MBioeth; Kelsey Poorman; W. M. Korn; Michael B. Atkins, MD; Immune Cell Biology Angiogenesis; Biomarkers; Checkpoint blockade; Gene expression; Immune suppression; T cell; Tumor infiltrating lymphocytes (TILs); Tumor microenvironment
496 Poster Presentation Immune cell profiling across solid tumor types by mass cytometry reveals tumor enrichment of PD-1+/LAG-3+ CD8 memory T cells that exhibit tumor-reactive yet dysfunctional features Bradley Garman, MSc; Laurence Menard, PhD; Can Jiang, MSc; Sherif Daouti, MSc; Priyanka Mehta, MSc; Miye Jacques, MSc; Mohan Bolisetty, PhD; Christos Hatzis, PhD; Nataly Manjarrez Orduno, PhD; Michaela Bowden, PhD; Justin M. David, PhD; Justin M. David, PhD; Justin M. David, PhD; Immune Cell Biology Immune contexture; T cell lineages; Tumor infiltrating lymphocytes (TILs); Tumor microenvironment
497 Poster Presentation Longitudinal immune profiling reveals unique myeloid and T cell phenotypes associated with spontaneous immunoediting in a novel prostate tumor model Casey R. Ager, PhD; Aleksander Obradovic; Juan M. Arriaga, PhD; Matthew G. Chaimowitz; Cory Abate-Shen, PhD; Andrea Califano, PhD; Charles G. Drake, MD, PhD; Immune Cell Biology Dendritic cell; Granulocyte; Immune contexture; Immune monitoring; Monocyte/Macrophage; Myeloid cells; Regulatory T cell (Treg cell); T cell; Tumor evasion; Tumor microenvironment
498 Poster Presentation Downregulation of CD5 in CD8+ T tumour-infiltrating lymphocytes associates with increased level of activation and exhaustion Faizah Alotaibi; Mark D. Vincent, MD, FRCPC, MRCPUK; Weiping Min; James Koropatnick; Immune Cell Biology Checkpoint blockade; Immune suppression; Immune tolerance; T cell; T cell lineages; Tumor infiltrating lymphocytes (TILs); Tumor microenvironment
499 Poster Presentation AT1636, a colon cancer survivor-derived antibody recognizes a previously unidentified truncated, O-mannosylated 70kDa variant of E-cadherin. Tim Beaumont, PhD; Martijn Kedde, PhD; Sabrina J. Merat, MSc; Mark J. Kwakkenbos, PhD; Lina Bartels; Dorien van der Berg; Koen Wagner, PhD; Arjen Q. bakker; Kelly Maijoor; Martino Bohne; Camille Bru; Veronika Kattler; Yvonne Claassen; Gemma Moiset, PhD; Hans Van Eenennaam, PhD; Victorine Roos; Frank Kallenberg; Jan P. Medema; Paul J. Hensbergen; Pauline M. van Helden, PhD; Evelien Dekker; Hergen Spits, PhD; Immune Cell Biology Antibody; B cell; Bispecifics; Post-translational modifications; Solid tumors; Targeted therapy; Tumor antigens
500 Poster Presentation P2RX7 agonist treatment boosts the ability of IL-12-activated CD8+ T cells to infiltrate and control murine melanoma Kelsey M. Wanhainen; Stephen C. Jameson; Henrique Borges Da Silva, PhD; Immune Cell Biology Adoptive immunotherapy; Immune adjuvant; Metabolism; T cell; Tumor infiltrating lymphocytes (TILs)
501 Poster Presentation VISTA regulates the differentiation and suppressive function of myeloid-derived suppressor cells Juan Dong, MD; Cassandra Gilmore; Hieu M. Ta, PhD; Keman Zhang; Sarah Stone; Li Wang, PhD; Immune Cell Biology Antibody; Immune suppression; MDSC; Myeloid cells; Tumor infiltrating lymphocytes (TILs); Tumor microenvironment
502 Poster Presentation The co-expression of two immune complex molecules, VISTA and TIGIT, define a dysfunctional cytotoxic T cell subset Cassandra K. Gilmour, BS; Li Wang, PhD; Juan Dong, MD; Hieu M. Ta, PhD; Immune Cell Biology Biomarkers; Checkpoint blockade; Costimulation; Immune suppression; T cell; T cell lineages; Tumor infiltrating lymphocytes (TILs); Tumor microenvironment
503 Poster Presentation Tumor infiltrating lymphocytes in soft tissue sarcomas upregulate the exhaustion marker TIGIT and are reinvigorated by IL-15 stimulation and TIGIT blockade Sean J. Judge, MD, MS; Morgan A. Darrow, MD; Steven W. Thorpe, MD; Alicia A. Gingrich, MD; Edmond F. O'Donnell, MD; Alyssa R. Bellini, MD; Ian R. Sturgill; Logan V. Vick; Cordelia M. Dunai, MS; Kevin M. Stoffel, MS; Yue M. Lyu; Shuai M. Chen, PhD; May M. Cho, MD; Robert M. Rebhun, DVM PhD; Arta M. Monjazeb, MD, PhD; William J. Murphy, PhD; Robert J. Canter, MD, MAS, FACS; Immune Cell Biology NK/NK T cell; Solid tumors; T cell; Tumor infiltrating lymphocytes (TILs); Tumor microenvironment
504 Poster Presentation Using multiplexed immunofluorescence to quantitatively analyze myeloid derived suppressor cells (MDSCs) in relation to tertiary lymphoid structures (TLS) in bladder cancer Anna Juncker-Jensen, PhD; Gang Huang; Mate L. Nagy; Xin Lu; Anna Juncker-Jensen, PhD; Anna Juncker-Jensen, PhD; Immune Cell Biology Adoptive immunotherapy; B cell; Immune contexture; Immune suppression; MDSC; Monocyte/Macrophage; Myeloid cells; Tumor infiltrating lymphocytes (TILs); Tumor microenvironment; Tumor stroma
505 Poster Presentation Activation of NK T cells promote the inflammatory tumor microenvironment and control the growth of solid tumor Sourav Paul, PhD; Amrita Mishra, MSc; Sushanta Chhatar; Girdhari Lal, PhD; Girdhari Lal, PhD; Immune Cell Biology Chemotherapy; Costimulation; Cytokine; Immune adjuvant; Inflammation; NK/NK T cell; Solid tumors; T cell; Tumor infiltrating lymphocytes (TILs); Tumor microenvironment
506 Poster Presentation The tumor immune microenvironment of metastatic osteosarcoma is marked by lymphocyte exclusion and impacts patient progression-free survival John A. Ligon, MD; Woonyoung Choi; Gady Cojocaru; Wei Fu; Emily H. Hsiue, MD; Teniola F. Oke; Carol D. Morris; Adam Levin; Daniel S. Rhee; David J. McConkey; Robert A. Anders, MD, PhD; Drew M. Pardoll, MD, PhD; Nicolas J. Llosa, MD; Immune Cell Biology Checkpoint blockade; Chemokine; Cytokine; Myeloid cells; MDSC; Solid tumors; Tumor microenvironment
507 Poster Presentation High dimensional flow cytometry analysis in newly diagnosed acute myeloid leukemia predicts patients outcomes Francesco Mazziotta, MD; Rupkatha Mukhopadhyay; Hanna A. Knaus; Anish Chowdhury; Amanda Blackford; Ivana Gojo, MD; Leo Luznik, MD; Immune Cell Biology Bioinformatics; Chemotherapy; Immune contexture; Immune monitoring; Leukemia/Lymphoma; T cell; T cell lineages; Tumor infiltrating lymphocytes (TILs); Tumor microenvironment
508 Poster Presentation Different neoantigen expression patterns impact the strength of anti-tumor immune responses Kim B. Nguyen, B.A.; Stefani Spranger, PhD; Christopher J. Copeland, B.S.; Immune Cell Biology Immune suppression; Neoantigens; T cell; Tumor infiltrating lymphocytes (TILs)
509 Poster Presentation Potent And Selective Inhibition Of AXL Receptor Tyrosine Kinase For The Treatment of Cancer Susan L. Paprcka, PhD; Akshata R. Udyavar, Ph.D; Subhasree Sridhar; Dillon H. Miles, PhD; Yu Chen, PhD; Sean Cho, PhD; Corinne N. Foley, PhD; Rebecca Grange, PhD; Manmohan R. Leleti, PhD; Sharon Zhao, PhD; Lixia Jin, PhD; Stephen W. Young, PhD; Jay P. Powers, PhD; Matthew J. Walters, PhD; Immune Cell Biology Dendritic cell; Gene expression; Immune suppression; Immune tolerance; Monocyte/Macrophage; Myeloid cells; NK/NK T cell; Solid tumors; Targeted therapy; Tumor microenvironment
510 Poster Presentation Helping the killers: innovative cancer immunotherapy harnessing quasi-universal tumor antigen-specific CD4 T cells Margaux Saillard; Amelie Cachot; Georg Alexander Rockinger; Philippe Guillaume; Julien Schmidt, PhD; Alexandre Harari, PhD; Camilla Jandus, MD, PhD; Pedro J. Romero, MD; Immune Cell Biology Antigen presenting cells; T cell; Tumor antigens; Vaccine
511 Poster Presentation Tumor immune microenvironment in adult mice asynchronously cross-fostered as pups Vianca Vianzon, BS; Ishita Garg; Kara G. Greenfield; Kathryn A. Knoop, PhD; Laura M. Rogers, PhD; Immune Cell Biology Immune tolerance; Microbiome; Tumor infiltrating lymphocytes (TILs)
512 Oral Presentation Terminally exhausted CD8+ T cells potentiate the tolerogenic tumor microenvironment as functional suppressors Paolo DA. Vignali, BA; Kristin DePeaux, BS; McLane Watson, BS; Ashley Menk, MS; Nicole E. Scharping, PhD; Greg M. Delgoffe, PhD; Immune Cell Biology Immune suppression; Metabolism; T cell; Tumor infiltrating lymphocytes (TILs); Tumor microenvironment
513 Poster Presentation CD26 enzymatic activity modulates efficient migration of adoptively transferred T cells to solid tumors Megan M. Wyatt, MS; Michelle H. Nelson, PhD; Stefanie R. Bailey, PhD; Hannah M. Knochelmann, BS; Aubrey S. Smith, BS; Guillermo O. Rangel RIvera, B.S.; Amalia M. Rivera Reyes, BS; Chrystal M. Paulos, PhD; Immune Cell Biology Adoptive immunotherapy; Chemokine; Costimulation; Solid tumors; T cell
514 Poster Presentation Disturbed Mitochondrial Dynamics Rewire the Epigenetic Program for CD8+ TIL Exhaustion Yi-Ru Yu, PhD; Haiping Wang; Fabien Franco; Ping-Chih Ho, PhD; Immune Cell Biology Metabolism; T cell; Tumor infiltrating lymphocytes (TILs); Tumor microenvironment
515 Oral Presentation Metabolic reprogramming of antitumor CD8+ T cell immunity Alison Jaccard, MS; Mathias Wenes, PhD; Gábor Gyülvészi; Ping-Chih Ho, PhD; Pedro J. Romero, MD; Immune Cell Biology Adoptive immunotherapy; Epigenetics; Immune monitoring; Metabolism; Post-translational modifications; Solid tumors; T cell; Tumor infiltrating lymphocytes (TILs); Tumor microenvironment
516 Poster Presentation Caspase-8 regulated senescence as an immune checkpoint in T lymphocytes for adoptive cell therapy Valérie Janelle, PhD; Mathieu Neault, PhD; Marie-Eve Lebel, PhD; Dave De Sousa, MSc; Salix Boulet, PhD; Ludovic Durrieu, PhD; Cedric Carli, PhD; Sebastien Lemieux, PhD; Nathalie Labrecque, PhD; Heather J. Melichar, PhD; Frederick A. Mallette, PhD; Jean-Sebastien Delisle, PhD, MD; Immune Cell Biology Adoptive immunotherapy; Bioinformatics; CAR T cells; Gene expression; Leukemia/Lymphoma; Metabolism; T cell; Targeted therapy
517 Oral Presentation Regulatory T cell functional identity is sustained by a glucose:lactate axis that is exploited in the tumor microenvironment McLane Watson, BS; Paolo DA. Vignali, BA; Steven Mullet; Abigail E. Overacre-Delgoffe, PhD; Ronal M. Peralta; Stephanie Grebinoski; Ashley Menk, MS; Natalie Rittenhouse; Kristin DePeaux, BS; Ryan D. Whetstone, MS, PhD; Dario A. Vignali, PhD; Timothy W. Hand, PhD; Amanda Poholek; Brett Morrison, MD, PhD; Jeffrey Rothstein; Stacy Wendell, PhD; Greg M. Delgoffe, PhD; Immune Cell Biology Metabolism; Regulatory T cell (Treg cell); Tumor evasion; Tumor microenvironment
518 Poster Presentation Epigenetic dysfunction of terminally exhausted tumor infiltrating T cells Rhodes Ford, BSc; Paolo DA. Vignali, BA; Natalie Rittenhouse; Nicole Scharping; Andrew Frisch; Greg M. Delgoffe, PhD; Amanda Poholek; Immune Cell Biology Bioinformatics; Epigenetics; Gene expression; T cell; T cell lineages; Tumor infiltrating lymphocytes (TILs); Tumor microenvironment
519 Poster Presentation Diacylglycerol kinase ζ limits IL-2-dependent control of PD-1 expression in tumor-infiltrating T lymphocytes Javier Arranz-Nicolas, PhD; Cristina Rodríguez-Rodríguez; Rosa Liébana; Judith Leitner; Antonia Ávila-Flores; Peter Steinberger; Isabel Mérida; Immune Cell Biology Antibody; Biomarkers; Checkpoint blockade; Costimulation; Immune suppression; T cell; Tumor infiltrating lymphocytes (TILs)
520 Poster Presentation The immune landscape of pediatric tumors Shimaa M. Sherif, MSc.; Jessica Roelands, Master; William Mifsud; Blessing Dason; Darawan Rinchai, PhD; Adrian Charles; Ayman Saleh; Chiara Cugno, MD; Khalid Fakhro; Borbala Mifsud; Davide Bedognetti, MD, PhD; Wouter RL. Hendrickx, PhD; Immune Cell Biology Bioinformatics; Biomarkers; Gene expression; Immunoscore; Pediatric tumors; Solid tumors; T cell; Tumor infiltrating lymphocytes (TILs); Tumor microenvironment; RNA
521 Poster Presentation Immune Regulatory Metabolites in Human Ovarian Cancer Julian J. Lum, PhD; Marisa Kilgour, BSc; Sarah MacPherson; Lauren Zacharias; Sarah Keyes; Bertrand Allard, PhD; Julian Smazynski; Peter Watson; John Stagg, PhD; Bradley Nelson, PhD; Ralph Deberardinis; Phineas Hamilton; Julian J. Lum, PhD; Immune Cell Biology Immune suppression; Metabolism; Tumor infiltrating lymphocytes (TILs)
522 Poster Presentation Metabolic requisites for T cell protein translation in tumors Katie E. Hurst; Megan Tennant; Megan Tennant; Alex M. Andrews, PhD; Lee Leddy, MD, MsCR; David M. Neskey, MD; Lauren Ball, PhD; Jessica E. Thaxton, PhD, MS; Immune Cell Biology Metabolism; T cell; Tumor infiltrating lymphocytes (TILs); Tumor microenvironment
523 Poster Presentation A subset of mature neutrophils contains the strongest PMN-MDSC activity in blood and tissue of patients with head and neck cancer Yu Si; Kirsten Bruderek; Simon Merz; Philip Jansen; Stephan Lang; Matthias Gunzer; Joachim Klode; Anthony Squire; Sven Brandau, PhD; Immune Cell Biology Biomarkers; Granulocyte; Immune monitoring; Inflammation; MDSC; Myeloid cells; Solid tumors; Tumor microenvironment; Tumor stroma
524 Poster Presentation Tim-4+ Resident Macrophages Impair Anti-Tumor Immunity In the Serous Body Cavities By Sequestering Viable and Cytotoxic CD8+ T cells Expressing High Levels of Phosphatidylserine Andrew Chow, MD, PhD; Sara Schad, BS; Michael D. Green, MD, PhD; Matthew D. Hellmann, MD; Nicholas Ceglia, PhD; Viola Allaj; Giulia Zago, PhD; Nisarg Shah; Sai K. Sharma, PhD; Marissa Mattar; Joseph Chan, MD, PhD; Hira Rizvi; Hong Zhong, BS; Cailian Liu, MD; Yonina Bykov; Dmitriy Zamarin, MD, PhD; Hongyu Shi; Sadna Budhu, PhD; Corrin Wohlhieter; Fathema Uddin; Aditi Gupta, MD; Inna Khodos; Jessica J. Waninger, BS; Angel Qin; Vinod Balachandran, MD; Weiping Zou, MD, PhD; Sohrab Shah, PhD; Andrew McPherson, PhD; Katherine S. Panageas, PhD; Jason S. Lewis, PhD; Justin Perry, PhD; Elisa de Stanchina, PhD; Triparna Sen, PhD; John T. Poirier, PhD; Jedd D. Wolchok, MD, PhD; Charles M. Rudin, MD, PhD; Taha Merghoub, PhD; Immune Cell Biology Checkpoint blockade; Gene expression; Immune contexture; Immune suppression; Monocyte/Macrophage; Solid tumors; T cell; Tumor evasion; Tumor microenvironment
525 Poster Presentation KIT mutation with a low MS4A1/CD20 expression is associated with poor prognosis in melanoma Shashank Cingam, MD; Moises Harari-Turquie, MD; Dulcinea Quintana, MD; Leslie Andritsos, MD; Emrullah Yilmaz, MD, PhD; Immune Cell Biology B cell; Checkpoint blockade; Targeted therapy; Tumor microenvironment
526 Poster Presentation InhibigenTM-specific responses suppress anti-tumor immunity and promote tumor growth Victoria L. DeVault, PhD; Tulin Dadali, PhD; Hanna Starobinets, PhD; Kevin Lema; Stephanie Rinaldi; Osaruese Odeh; Julie N. Arnold; Dylan Sheehan; Cindy K. Nguyen; Louisa Dowal, PhD; Jessica B. Flechtner, PhD; Alberto Visintin, PhD; Hubert Lam, PhD; Immune Cell Biology Antigen presenting cells; Checkpoint blockade; Immune suppression; Neoantigens; T cell; Targeted therapy; Tumor antigens; Tumor microenvironment
527 Poster Presentation Tumor organoid and immune cell co-culture system potentiates Immuno-Oncology drug development Hongjuan Zhang, PhD; Jun Zhou; Shuang Zhu; Jia Zheng; Limei Shang; Chunmei Li; Xuefei Yan, PhD; Rui Zhang; Mingfa Zang; Annie Xiaoyu An; Xiaoxi Xu; Shuzong Wang; Henry Q. Li; Yujun Huang; Immune Cell Biology Bispecifics; CAR T cells; Checkpoint blockade; T cell; Tumor antigens; Tumor infiltrating lymphocytes (TILs); Tumor microenvironment
528 Oral Presentation Sexual dimorphism in myeloid-derived suppressor cells promote GBM progression in females via IL-1b Defne Bayik, PhD; Yadi Zhou; Chihyun Park; Chngjin Hong; Danielle Silver, PhD; Dionysios C. Watson, MD; Alice Lo; Tae Hyun Hwang; Feixiong Cheng; Peter A. Sims; Antonio Iavarone; Justin D. Lathia, PhD; Immune Cell Biology Cytokine; Granulocyte; Immune suppression; Myeloid cells; MDSC; Tumor microenvironment
529 Poster Presentation Cancer cells educate natural killer cells to a metastasis promoting cell state Isaac S. Chan, MD, PhD; Hildur Knu´tsdo´ttir, PhD; Gayathri Ramakrishnan; Veena Padmanaban; Manisha Warrier; Juan Carlos Ramirez; Joel S. Bader; Elizabeth M. Jaffee, MD; Isaac S. Chan, MD, PhD; Andrew Ewald; Immune Cell Biology NK/NKT cell; Tumor evasion; Tumor microenvironment
530 Poster Presentation T-cell immunoglobulin– and mucin domain–containing (TIM)–3 downregulation in response to ex vivo activation and cancer targets correlates to NK cell functionality. Tram N. Dao, BS; Sandro Matosevic, PhD; Sagar Utturkar, PhD; Nadia A. Lanman, PhD; Sandro Matosevic, PhD; Immune Cell Biology Cytokine; NK/NK T cell; Solid tumors; Tumor infiltrating lymphocytes (TILs)
531 Oral Presentation AFM13-targeted blood and cord-blood-derived memory-like NK cells as therapy for CD30+ malignancies Lucila Kerbauy; Nancy D. Marin, PhD; Mecit Kaplan; Pinaki Banerjee; Melissa Berrien-Elliott; Michelle Becker-Hapak; Rafet Basar; Mark Foster; Luciana Garcia Melo; Carly Neal; Ethan McClain; May Daher, MD; Ana Karen Nunez Cortes; Sweta Desai; Francesca Wei Inng Lim; Mayela Carolina Mendt; Timothy Schappe; Li Li; Hila Shaim; Mayra Hernandez Sanabria; Pamela Wong; Enli Liu; Sonny Ang; Rong Cai; Vandana Nandivada; Vakul Mohanty; Yifei Shen; Natalia Baran; Natalie Fowlkes; Ken Chen; Luis Muniz-Feliciano; Joachim Koch, PhD; Martin Treder; Wolfgang Fischer; Oswaldo Keith Okamoto; Yago Nieto, MD PhD; Richard E. Champlin, MD; Elizabeth J. Shpall, MD; Todd A. Fehniger; Katy Rezvani, MD, PhD; Immune Cell Biology Antibody; Bispecifics; NK/NK T cell; Targeted therapy
532 Poster Presentation SOCS3 deficiency blocked autophagy-dependent myeloid differentiation of early-stage myeloid-derived suppressor cells via the miR-155/C/EBPß/Wnt axis Jinpu Yu, Ph.D.; Wenwen Zhang; Immune Cell Biology Carcinogenesis; Immune suppression; MDSC; Tumor evasion; Tumor microenvironment
827 Poster Presentation Elucidating the Roles of PIK3IP1/TrIP Immune Regulation on Distinct T Cell Subsets in the Context of Cancer Benjamin M. Murter, BS; Lawrence P. Kane, PhD; Immune Cell Biology Solid tumors; T cell; T cell lineages; Tumor microenvironment
828 Poster Presentation Improved growth properties and immune surveillance in K-RAS G12V-transformed cells through overexpression of biglycan Karthikeyan Subbarayan, MSc; Sandra Leisz; Chiara Massa, PhD; Sravankumar Balina; Anja Müller; Claudia Wickenhauser, MD, PhD; Barbara Seliger, MD, PhD; Immune Cell Biology Antigen presenting cells; Bioinformatics; Biomarkers; Gene expression; Solid tumors; Tumor antigens; Tumor evasion; Tumor microenvironment
829 Poster Presentation Tumor alpha-fetoprotein inhibits cholesterol and steroid metabolism in monocyte-derived dendritic cells Paul Munson, PhD; Juraj Adamik, PhD; Lisa H. Butterfield, PhD; Immune Cell Biology Dendritic cell; Gene expression; Immune suppression; Monocyte/Macrophage; Myeloid cells; Metabolism
830 Poster Presentation Targeting cellular senescence to increase CAR-T cell fitness Rashmi Bankoti; Hazal Pektas Akbal; Maddalena Adorno; Benedetta N. Di Robilant; Immune Cell Biology Epigenetics; Adoptive immunotherapy; CAR T cells; Checkpoint blockade; Immune adjuvant; Leukemia/Lymphoma; Stem cell/cancer-initiating cell; Solid tumors
831 Poster Presentation E3 ubiquitin ligase Cbl-b deficient CD8+ T cells overcome Treg cell-mediated suppression through IFN-γ and induce robust anti-tumor immunity SeongJun Han, MSc; Zhe Qi Liu; Douglas Chung; Michael St. Paul; Carlos Garcia-Batres; Azin Sayad; Alisha R. Elford; Matthew J. Gold; Natasha Grimshaw; Pamela S. Ohashi, PhD; Immune Cell Biology Adoptive immunotherapy; Cytokine; Immune suppression; Immune tolerance; Regulatory T cell (Treg cell); Solid tumors; T cell; Tumor microenvironment
832 Poster Presentation Unravelling human melanoma heterogeneity by 6-color multiplex immunofluorescence to overcome recurrence and resistance to therapy Marcella Willemsen, MSc; Jenny Bulgarelli; Sudhir C. Kumar; Massimo Guidoboni, MD; John A. Kyte; Irwin Davidson; Rosalie M. Luiten; Immune Cell Biology Checkpoint blockade; T cell; Tumor antigens; Tumor evasion; Tumor microenvironment
833 Poster Presentation The epigenomic landscape of human glioma-associated myeloid cells Pravesh Gupta, PhD; Dapeng Hao, Ph.D.; Krishna Bojja Bojja; Tuan M. Tran; Minghao Dang, PhD; Jianzhuo Li; Atul Maheshwari, MD; Nicholas Navin, PhD; Linghua Wang, PhD; Krishna P. Bhat, PhD; Pravesh Gupta, PhD; Immune Cell Biology Epigenetics; Immune contexture; Monocyte/Macrophage; Myeloid cells; Tumor microenvironment
834 Poster Presentation CRISPR-mediated in situ editing of liver resident macrophages for treating liver cancers Zhutian Zeng; Wei Liu; Immune Cell Biology Monocyte/Macrophage; Myeloid cells; Targeted therapy