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8:00am -
8:30am |
Introductory Remarks
Ulrich Keilholz, MD • Charité CBF, Berlin, Germany
Walter Urba, MD, PhD • Earle A. Chiles Research Institute, Portland, OR
Jeffrey Weber for Steven Hirschfeld • FDA Office of Cellular, Tissue, Gene Therapy,
Center for Biologics Evaluation & Research, Rockville, MD |
8:30am - 10:00am |
State of the Field Lectures |
8:30am - 8:45am |
Clinical Trial to Assess Vaccine Characteristics
Jeffrey S. Weber, MD, PhD • University of Southern California, Norris Cancer Center,
Los Angeles, CA |
8:45am - 9:00am |
Assay Validation for Vaccine Potency Assessment
Mary L. Disis, MD • University of Washington, Department of Oncology, Seattle, WA |
9:00am - 9:15am |
Monitoring of Multi-Antigen Vaccines
Craig Slingluff, Jr., MD • University of Virginia, Charlottesville, VA |
9:15am - 9:30am |
Functional Cytometry
Vernon Maino, PhD • BD Biosciences, San Jose, CA |
9:30am - 9:45am |
Migration of Tumor-Specific T Cells
Carmen Scheibenbogen, MD • Med Klinik III, Charité, CBF, Berlin, Germany |
9:45am - 10:00am |
Tumor Escape Mechanisms: Clinical Observations
Cassian Yee, MD |
10:15am - 12:30pm |
Abstract Session: Immune Monitoring of Cancer Treatments
Michael B. Atkins, MD • Beth Israel Deaconess Medical Center, Boston, MA
Michael T. Lotze, MD • University of Pittsburgh, School of Medicine, Pittsburgh, PA |
10:15am - 10:30am |
Maximizing the Retention of Antigen Specific Lymphocyte Function after
Cryopreservation
Corazon dela Rosa • University of Washington, Department of Oncology, Seattle, WA |
10:30am - 10:45am |
MHC Class II Tetramers Quantitatively Detect DP-4 Restricted, Antigen Specific CD4+ T
Lymphocytes
Kristine Kuus-Reichel, PhD • Beckman Coulter Inc., San Diego, CA |
10:45am - 11:00am |
Effect of Cryopreservation on Assays of Antigen-Specific T Cells: Comparison of Tetramer,
Cytokine Flow Cytometry, and ELISPOT
Holden Maecker, PhD • BD Biosciences, San Jose, CA |
11:00am - 11:15am |
Some but Not all Memory CD8 T Cell Subsets Produce Both IFN-γ and IL-2: Comparison of
Viral- and Tumor- Specific T Cells in Cancer Patients and Healthy Donors
Nadege Bercovici, PhD • IDM Paris, France |
11:15am - 11:30am |
CD8δ/δ+ Melan-A/MART-1 Specific T-Cells in Patients with Melanoma
Isabelle Magalhaes • University of Mainz, Mainz, Germany |
11:30am - 11:45am |
Standardization of MHC Tetramer and ELISPOT Assays To Quantitate Antigen-Specific
T Cell Expansion after CTLA4 Blockade
Antoni Ribas, MD • University of California Los Angeles Medical Center,
Los Angeles, CA |
11:45am - 12:00pm |
The IFN-γ and GrB Elispot Assays: Partners for Monitoring Clinical Immune Responses
Kimberly A. Shafer-Weaver, PhD • National Cancer Institute, Frederick, MD |
12:00pm - 12:15pm |
Adenovirus Mediated Interferon-gamma Expression in Cutaneous Lymphoma: Monitoring
of Local and Systemic Events
Reinhard Dummer, MD • University Hospital of Zurich, Zurich, Switzerland |
10:15am - 12:30pm |
Breakout Sessions |
10:15am - 12:30pm |
Breakout Sessions: Assay Methodology and Validation
Functional Cytometry
Ulrich Keilholz, MD • Charité, CBF, Berlin, Germany
Vernon Maino, PhD • BD Biosciences, San Jose, CA
Assay Validation for Vaccine Potency Assessment
S. Rafat Husain, PhD • FDA, Center for Biologics Evaluation & Research, Bethesda, MD
Mary L. Disis, MD • University of Washington, Department of Oncology, Seattle, WA
Montoring of Multi-Antigen Vaccines
Craig L. Slingluff, Jr., MD • University of Virginia, Department of Surgery,
Charlottesville, VA |
10:15am - 12:30pm |
Breakout Sessions: Clinical Trial Methodology and Observations
Clinical Trials to Assess Vaccine Characteristics
Jeffrey S. Weber, MD, PhD • University of Southern California, Norris Cancer Center
Los Angeles, CA
Walter Urba, MD, PhD • Earle A. Chiles Research Institute, Portland, OR
Migration of Tumor-Specific T Cells
Carmen Scheibenbogen, MD • Med Klinik III, Charité, CBF, Berlin, Germany
Patrick Hwu, MD • MD Anderson Cancer Center, Houston, TX
Tumor Escape Mechanisms: Clinical Observations
Cassian Yee, MD • Fred Hutchinson Cancer Research Center, Seattle, WA
Pedro J. Romero, MD • Ludwig Institute for Cancer Research, Lausanne, Switzerland |
1:30pm - 2:00pm |
Special Lecture
Genomics and Proteomics in Immunotherapy Trials
Francesco Marincola, MD • National Institutes of Health, Clinical Center,
Bethesda, MD |
2:00pm - 4:30pm |
Reporting Session/Panel Discussion
Report on Functional Cytometry
Ulrich Keilholz, MD
Vernon Maino, PhD
Report on Assay Validation for Vaccine Potency Assessment
S. Rafat Husain, PhD
Mary L. Disis, MD
Report on Montoring of Multi-Antigen Vaccines
Craig L. Slingluff, Jr., MD
Reporting Session/Panel Discussion
Report on Clinical Trials to Assess Vaccine Characteristics
Jeffrey S. Weber, MD, PhD
Walter Urba, MD, PhD
Report on Migration of Tumor-Specific T Cells
Carmen Scheibenbogen, MD
Patrick Hwu, MD
Report on Tumor Escape Mechanisms: Clinical Observations
Cassian Yee, MD
Pedro J. Romero, MD |
4:30pm - 5:00pm |
General Discussion: Consensus and Consequences |
5:00pm |
Farewell and Future Plans
Michael B. Atkins, MD |