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| 8:00am - 8:30am |
Introductory Remarks
Ulrich Keilholz, MD • Charité CBF, Berlin, Germany Walter Urba, MD, PhD • Earle A. Chiles Research Institute, Portland, OR
Jeffrey Weber for Steven Hirschfeld • FDA Office of Cellular, Tissue, Gene Therapy,
Center for Biologics Evaluation & Research, Rockville, MD |
| 8:30am - 10:00am | State of the Field Lectures |
| 8:30am - 8:45am |
Clinical Trial to Assess Vaccine Characteristics Jeffrey S. Weber, MD, PhD • University of Southern California, Norris Cancer Center, Los Angeles, CA |
| 8:45am - 9:00am |
Assay Validation for Vaccine Potency Assessment Mary L. Disis, MD • University of Washington, Department of Oncology, Seattle, WA |
| 9:00am - 9:15am |
Monitoring of Multi-Antigen Vaccines Craig Slingluff, Jr., MD • University of Virginia, Charlottesville, VA |
| 9:15am - 9:30am |
Functional Cytometry Vernon Maino, PhD • BD Biosciences, San Jose, CA |
| 9:30am - 9:45am |
Migration of Tumor-Specific T Cells Carmen Scheibenbogen, MD • Med Klinik III, Charité, CBF, Berlin, Germany |
| 9:45am - 10:00am |
Tumor Escape Mechanisms: Clinical Observations Cassian Yee, MD |
| 10:15am - 12:30pm | Abstract Session: Immune Monitoring of Cancer Treatments Michael B. Atkins, MD • Beth Israel Deaconess Medical Center, Boston, MA Michael T. Lotze, MD • University of Pittsburgh, School of Medicine, Pittsburgh, PA |
| 10:15am - 10:30am |
Maximizing the Retention of Antigen Specific Lymphocyte Function after
Cryopreservation Corazon dela Rosa • University of Washington, Department of Oncology, Seattle, WA |
| 10:30am - 10:45am |
MHC Class II Tetramers Quantitatively Detect DP-4 Restricted, Antigen Specific CD4+ T
Lymphocytes Kristine Kuus-Reichel, PhD • Beckman Coulter Inc., San Diego, CA |
| 10:45am - 11:00am |
Effect of Cryopreservation on Assays of Antigen-Specific T Cells: Comparison of Tetramer,
Cytokine Flow Cytometry, and ELISPOT Holden Maecker, PhD • BD Biosciences, San Jose, CA |
| 11:00am - 11:15am | Some but Not all Memory CD8 T Cell Subsets Produce Both IFN-γ and IL-2: Comparison of
Viral- and Tumor- Specific T Cells in Cancer Patients and Healthy Donors Nadege Bercovici, PhD • IDM Paris, France |
| 11:15am - 11:30am |
CD8δ/δ+ Melan-A/MART-1 Specific T-Cells in Patients with Melanoma Isabelle Magalhaes • University of Mainz, Mainz, Germany |
| 11:30am - 11:45am |
Standardization of MHC Tetramer and ELISPOT Assays To Quantitate Antigen-Specific
T Cell Expansion after CTLA4 Blockade Antoni Ribas, MD • University of California Los Angeles Medical Center, Los Angeles, CA |
| 11:45am - 12:00pm | The IFN-γ and GrB Elispot Assays: Partners for Monitoring Clinical Immune Responses Kimberly A. Shafer-Weaver, PhD • National Cancer Institute, Frederick, MD |
| 12:00pm - 12:15pm |
Adenovirus Mediated Interferon-gamma Expression in Cutaneous Lymphoma: Monitoring
of Local and Systemic Events Reinhard Dummer, MD • University Hospital of Zurich, Zurich, Switzerland |
| 10:15am - 12:30pm | Breakout Sessions |
| 10:15am - 12:30pm | Breakout Sessions: Assay Methodology and Validation Functional Cytometry Ulrich Keilholz, MD • Charité, CBF, Berlin, Germany Vernon Maino, PhD • BD Biosciences, San Jose, CA Assay Validation for Vaccine Potency Assessment S. Rafat Husain, PhD • FDA, Center for Biologics Evaluation & Research, Bethesda, MD Mary L. Disis, MD • University of Washington, Department of Oncology, Seattle, WA Montoring of Multi-Antigen Vaccines Craig L. Slingluff, Jr., MD • University of Virginia, Department of Surgery, Charlottesville, VA |
| 10:15am - 12:30pm | Breakout Sessions: Clinical Trial Methodology and Observations Clinical Trials to Assess Vaccine Characteristics Jeffrey S. Weber, MD, PhD • University of Southern California, Norris Cancer Center Los Angeles, CA Walter Urba, MD, PhD • Earle A. Chiles Research Institute, Portland, OR Migration of Tumor-Specific T Cells Carmen Scheibenbogen, MD • Med Klinik III, Charité, CBF, Berlin, Germany Patrick Hwu, MD • MD Anderson Cancer Center, Houston, TX Tumor Escape Mechanisms: Clinical Observations Cassian Yee, MD • Fred Hutchinson Cancer Research Center, Seattle, WA Pedro J. Romero, MD • Ludwig Institute for Cancer Research, Lausanne, Switzerland |
| 1:30pm - 2:00pm | Special Lecture
Genomics and Proteomics in Immunotherapy Trials Francesco Marincola, MD • National Institutes of Health, Clinical Center, Bethesda, MD |
| 2:00pm - 4:30pm | Reporting Session/Panel Discussion Report on Functional Cytometry Ulrich Keilholz, MD Vernon Maino, PhD Report on Assay Validation for Vaccine Potency Assessment S. Rafat Husain, PhD Mary L. Disis, MD Report on Montoring of Multi-Antigen Vaccines Craig L. Slingluff, Jr., MD Reporting Session/Panel Discussion Report on Clinical Trials to Assess Vaccine Characteristics Jeffrey S. Weber, MD, PhD Walter Urba, MD, PhD Report on Migration of Tumor-Specific T Cells Carmen Scheibenbogen, MD Patrick Hwu, MD Report on Tumor Escape Mechanisms: Clinical Observations Cassian Yee, MD Pedro J. Romero, MD |
| 4:30pm - 5:00pm | General Discussion: Consensus and Consequences |
| 5:00pm |
Farewell and Future Plans Michael B. Atkins, MD |
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