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All accepted abstracts will be available in the Journal for ImmunoTherapy of Cancer (JITC).

Abstract Titles

Onsite Posters

Onsite posters will be presented in the Poster Hall at the Walter E. Washington Convention Center in Washington, D.C. All odd numbered posters will be presented on Friday, Nov. 12, 2021. Even numbered posters will be presented Saturday, Nov. 13, 2021.

ePosters

ePosters will be on display on the SITC 2021 virtual meeting platform from 7 a.m. EST on Friday, Nov. 12, 2021 until the virtual meeting platform is closed on Jan. 9, 2022.


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# Type Title Authors Category Keywords
900 Oral Presentation Depleting non-canonical, cell-intrinsic PD-L1 signals induces synthetic lethality to small molecule DNA damage response inhibitors in an immune independent and dependent manner Anand V. Kornepati; Clare E. Murray; Barbara Avalos, PhD; Cody Rogers; Kavya Ramkumar; Harshita Gupta; Yilun Deng, PhD; Zexuan Liu; Alvaro Padron; Ratna Vadlamudi; Eloise Dray; Weixing Zhao; Patrick Sung; Lauren A. Byers; Tyler J. Curiel, MD Tumor and Stromal Cell Biology Checkpoint blockade;Chemotherapy;Immune suppression;Post-translational modifications;Solid tumors;Targeted therapy;Tumor evasion;Tumor microenvironment
901 Poster Presentation Bacillus Calmette-Guerin can subvert patients antitumor immune response by downregulating HLA-I expression on cancer cells Mathieu Rouanne, MD; Julien Adam; Camelia Radulescu; Diane Letourneur; Severine Mouraud; Delphine Bredel; Anne-Gaelle Goubet; Tuan Zea Tan; Amelie Bigorgne; Michael Dussiot; Lambros Tselikas, MD; Sandrine Susini; François-Xavier Danlos; Roman Chabanon; Nicolas Signolle; Anna Schneider; Sophie Vacher; Ivan Bieche; Thierry Lebret; Yves Allory; Jean-Charles Soria, MD, PhD; Jean Paul Thiery; Laurence Zitvogel, MD, PhD; Aurelien Marabelle Tumor and Stromal Cell Biology Biomarkers;Chemokine;Immune adjuvant;Immune suppression;Myeloid cells;T cell;TLR;Tumor evasion;Tumor microenvironment;Tumor stroma
902 Poster Presentation Comprehensive multi-omics meta-analysis of pancreatic cancer mouse models and human PDAC data sets identifies unique cancer-associated fibroblast subsets Candace Wai Sze Lei, MS; John Holt, MS; Brianna Flynn, MS; Richard Barrett, PhD; Pratha Budhani, MS; Mohanapriya Kamalakannan; Ruby Wasti; Lucinda Thiede; Joshua Tagore; Jessica Potts; Jacqueline Larouche; Marie Marcher; Xiaoyun Liao, PhD; Sarah O'Brien, PhD; Abhishek Kashyap, PhD; Jeanine Pignatelli, PhD; Kang Liu, PhD; Joseph Tumang, PhD; Emily Corse, PhD; Ben Stanger, MD, PhD; Ellen Pure, PhD; Varenka Rodriguez DiBlasi, PhD Tumor and Stromal Cell Biology Angiogenesis;Bioinformatics;Epigenetics;Gene expression;Immune suppression;Inflammation;Solid tumors;Tumor infiltrating lymphocytes (TILs);Tumor microenvironment;Tumor stroma
903 Poster Presentation Human cancer-associated fibroblast subsets can predict immune checkpoint response in head and neck cancer patients Diana K. Graves, B.S.; Aleksandar Obradovic; Michael J. Korrer, PhD; Yu Wang; Sohini Roy, PhD; Yaomin Xu; Adam Luginbuhl, MD; Joseph Curry, MD; Michael K. Gibson, MD PhD; Paula Hurley, PhD; Ravindra Uppaluri, MD/PhD; Charles G. Drake, MD, PhD; Andrea Califano, PhD; Young J. Kim, MD, PhD Tumor and Stromal Cell Biology Bioinformatics;Biomarkers;Checkpoint blockade;Solid tumors;T cell;Tumor infiltrating lymphocytes (TILs);Tumor microenvironment;Tumor stroma
904 Poster Presentation Repurposing CD26 (DPP4) inhibitors to enhance immunotherapy response in pancreatic ductal adenocarcinoma Maggie J. Phillips, BS; Michael B. Ware, PhD; Cameron Herting, PhD; Thomas A. Mace, PhD; Shishir K. Maithel, MD; Juan M. Sarmiento, MD; Bassel El-Rayes, MD; Chrystal M. Paulos, PhD; Megan M. Wyatt, MS; Gregory B. Lesinski, PhD Tumor and Stromal Cell Biology Checkpoint blockade;Gene expression;Immune suppression;Tumor evasion;Tumor microenvironment;Tumor stroma
905 Poster Presentation FASN prevents immunogenicity of irradiated glioblastoma by inhibiting ER stress Mara De Martino, PhD; Camille Daviaud; Claire I. Vanpouille-Box, PhD Tumor and Stromal Cell Biology Dendritic cell;Immune contexture;Immune suppression;Metabolism;Radiotherapy;Solid tumors;T cell;Targeted therapy;Tumor evasion;Tumor infiltrating lymphocytes (TILs)
906 Poster Presentation Immunogenomic evaluation of Clear Cell Renal Carcinoma uncovers HK3 as a myeloid specific metabolic enzyme Bradley I. Reinfeld, BA; Matthew z. Madden, BS; Melissa M. Wolf; Agi de Cubas, PhD; Scott Haake, MD; Rachel Hongo; Margaret L. Axelrod, BS; Jackie E. Bader, PhD; Aleksandar Obradovic; Dalton Greenwood; Xiang Ye, PhD; Justin M. Balko, PhD, PharmD; Katy Beckermann, MD/PhD; Benjamin G. Vincent, MD; Brian I. Rini, MD; Charles G. Drake, MD, PhD; Jeffrey C. Rathmell, PhD; W. K. Rathmell, MD, PhD Tumor and Stromal Cell Biology Inflammation;Metabolism;Monocyte/Macrophage;Solid tumors;Tumor evasion;Tumor infiltrating lymphocytes (TILs);Tumor microenvironment
907 Poster Presentation Modulation of tumor immunogenicity by DNA methylation of immune synapse genes in cancers Imene Hamaidi, PhD; Anders Berglund, PhD; Matthew Mills; Ryan M. Putney; James J. Mule, PhD; Sungjune Kim, MD PhD Tumor and Stromal Cell Biology Carcinogenesis;Epigenetics;Immune suppression;Immune tolerance;T cell;Tumor evasion
908 Poster Presentation Humanized model for assessment of therapies targeting either lymphoid or myeloid compartment: enhanced evaluation of clinical relevancy & translatability Florence Renart-Depontieu; Gaëlle Martin; Chloé Beuraud; Poonam Yakkundi; Angus M. Sinclair, PhD; Morgane Denis; Léa Magadoux; Elsa Kress; Charles Dumontet; Ludovic Bourre; Dean O. Campbell; Astrid Doerner; Patricia Isnard-Petit; Alexandre Fraichard; Yacine Cherifi; Kader Thiam Tumor and Stromal Cell Biology Cytokine;Immune monitoring;Immune toxicity;Inflammation;Monocyte/Macrophage;Myeloid cells;Regulatory T cell (Treg cell);T cell;Tumor infiltrating lymphocytes (TILs);Tumor microenvironment
909 Poster Presentation Differentiation subgroups within LKB1-deficient lung cancer influence both the immune exclusion phenotype and cellular composition of the immune microenvironment Jacob Kaufman, MD, PhD; Doug Cress; Theresa Boyle, PhD, MD; David P. Carbone, MD, PhD; Neal Ready, MD, PhD; Kris Wood Tumor and Stromal Cell Biology B cell;Bioinformatics;Biomarkers;Gene expression;Monocyte/Macrophage;Solid tumors;Tumor microenvironment
910 Poster Presentation Overexpression of miR-155-5p can upregulate antigen processing and presentation pathway via targeting tapasin Yuan Wang, M.Sc.; Maria-Filothei Lazaridou; Chiara Massa, PhD; Barbara Seliger, MD, PhD Tumor and Stromal Cell Biology Antigen presenting cells;RNA;Tumor evasion
911 Poster Presentation Immune profiling reveals enrichment of distinct immune signatures in high-risk oral potentially malignant disorders Chai Gan, MSc; Bernard Kok Bang Lee; Shin Hin Lau; Thomas George Kallarakkal; Zuraiza Mohamad Zaini; Rosnah Binti Zain; Hans Prakash Sathasivam; Joe Poh Sheng Yeong; Natalia Savelyeva; Gareth Thomas; Christian Ottensmeier; Hany Ariffin; Sok Ching Cheong; Kue Peng Lim Tumor and Stromal Cell Biology Bioinformatics;Gene expression;Immune contexture;Inflammation
912 Poster Presentation Preferential recognition of neoantigens over non-canonical peptides in cancer patients Maria Lozano-Rabella, MsC; Andrea Garcia-Garijo, MsC; Jara Palomero, PhD; Florian Erhard; Juan Martín-Liberal, MD; Ignacio Matos, MD; Jared Gartner; Steven A. Rosenberg, MD, PhD; Michael Ghosh; Francesc Canals, PhD; August Vidal, MD; Josep Maria Piulats, MD; Xavier Matias-Guiu; Irene Braña, MD; Eva Muñoz, MD; Elena Garralda; Andreas Schlosser, PhD; Alena Gros, PhD Tumor and Stromal Cell Biology Adoptive immunotherapy;Neoantigens;T cell;Tumor antigens;Tumor infiltrating lymphocytes (TILs)
913 Poster Presentation A murine gastric cancer YTN16 model for the rational design of combination immunotherapy Koji Nagaoka, PhD; Changbo Sun, MD; Yukari Kobayashi, BS; Kazuhiro Kakimi, MD, PhD Tumor and Stromal Cell Biology Neoantigens;T cell;Tumor antigens;Vaccine
914 Poster Presentation Loss of LKB1 is associated with resistance to IFN-gamma and T cell killing in non-small cell lung cancer Alexandre Reuben, PhD; Peixin Jiang; Hui Nie; Ana Galan Cobo; Minghao Dang; Yu Qian, PhD; Meredith Frank, MSc; Emily Blitz; Haifa Hamdi; Warren L. Denning; Monique Nilsson; Alissa Poteete; Li Shen; Qi Wang; Irene Guijarro; Keri Nichols; Roohussaba Khairullah; Jiexin RP. Zhang, PhD; Ferdinandos Skoulidis; Jing Wang; Linghua Wang, PhD; John V. Heymach, MD, PhD Tumor and Stromal Cell Biology Antigen presenting cells;Checkpoint blockade;Neoantigens;Solid tumors;T cell;Tumor antigens;Tumor infiltrating lymphocytes (TILs)
915 Poster Presentation Molecular characterization of AXL in solid tumor malignancies using real-world data Han Si, PhD; Maria Jure-Kunkel; Nora Pencheva; Steven Xu; Brandon Higgs; Kate Sasser, PhD; Hisham Hamadeh, PhD; Phaedra Agius; Kristina Grigaityte Tumor and Stromal Cell Biology Bioinformatics;Biomarkers;Checkpoint blockade;Chemotherapy;Gene expression;Solid tumors;Tumor antigens
916 Poster Presentation Understanding the effect of M1 macrophage subset on regulation of cancer stem cells Udit Basak, Bachelor of Technology Tumor and Stromal Cell Biology Epigenetics;Monocyte/Macrophage;Solid tumors;Tumor microenvironment
917 Poster Presentation Immune landscape at the invasion front of surgically resected oral squamous cell carcinomas shows significant associations with disease specific survival Jebrane BOUAOUD, MD PhD Student; Frank Rojas Alvarez, MD; Lucas Michon; Nicolas Gadot; Sylvie Lantuejoul; Auriole Tamegnon; Mei Jiang; Shanyu Zhang; Pandurengan Renganayaki; Philippe Zrounba; Jean-Philippe Foy; Karène Mahtouk, PhD; Chloé Bertolus, MD PhD; Edwin Roger Parra Cuentas, MD PhD; Pierre Saintigny Tumor and Stromal Cell Biology Immune contexture;Immune suppression;Monocyte/Macrophage;Solid tumors;Tumor infiltrating lymphocytes (TILs);Tumor microenvironment
918 Poster Presentation Doxycycline regulatable ß-catenin demonstrates inducible immune evasion in a melanoma GEM model. Alexandra Cabanov, BS; Stefani Spranger, PhD; Thomas F. Gajewski, MD, PhD; Elen Torres-Mejia, PhD Tumor and Stromal Cell Biology Checkpoint blockade;Tumor evasion;Tumor infiltrating lymphocytes (TILs);Tumor microenvironment
919 Poster Presentation Tegavivint reduces the immunosuppressive macrophage phenotype in a preclinical co-culture model of the non-small cell lung cancer tumor microenvironment Raghav Chandra, M.D.; Josiah Flaming, B.S.; Aiden Nguyen, B.S.; Michael Peyton, Ph.D.; Amit Das, Ph.D.; Boning Gao, Ph.D.; Steven K. Horrigan, Ph.D.; Rolf A. Brekken, PhD; John D. Minna, M.D. Tumor and Stromal Cell Biology Monocyte/Macrophage;Tumor microenvironment
920 Poster Presentation A Single-Cell Spatially Resolved MERFISH Map of the Colorectal Tumor Immune Microenvironment Colles Price, MS, PhD; Jonathan H. Chen, MD/PhD; Karin Pelka, PhD; Sherry Chao; Jiang He, PhD; Genevieve Boland, PhD; George Emanuel, PhD; Nir Hacohen, PhD Tumor and Stromal Cell Biology Bioinformatics;Gene expression;Immune monitoring;Monocyte/Macrophage;RNA;Solid tumors;T cell;Tumor microenvironment
921 Poster Presentation Comparison of PI3K/AKT/mTOR pathway profiles amongst three immune phenotypes classified by artificial intelligence-powered H&E analyzer in non-small cell lung cancer Hyung-Gyo Cho, MD; Grace Lee; Hye Sung Kim, MD; Sanghoon Song, MS; Kyunghyun Paeng; Chan-Young Ock, MD, PhD; Young Kwang Chae, MD, MPH, MBA Tumor and Stromal Cell Biology Gene expression;Immune contexture;Solid tumors;Tumor evasion;Tumor infiltrating lymphocytes (TILs);Tumor microenvironment
922 Poster Presentation A novel autotaxin inhibitor, IOA-289, modulates tumor, immune and stromal cell function and has monotherapy activity in fibrotic cancer models Marcel Deken; Karolina Niewola, PhD; Elisa Matas-Rico, PhD; Ragini Medhi, PhD; Alan Carruthers, PhD; Anne Cheasty, PhD; Olivier Peyruchaud, PhD; Amy Fraser, PhD; Pritom Shah, PhD; Wouter Moolenaar, PhD; Lars van der Veen, PhD; Michael Lahn, PhD, MD; ZOE JOHNSON, PhD Tumor and Stromal Cell Biology Bioinformatics;Biomarkers;Cytokine;Monocyte/Macrophage;Solid tumors;T cell;Tumor evasion;Tumor infiltrating lymphocytes (TILs);Tumor microenvironment;Tumor stroma
923 Poster Presentation Hedgehog Signaling Drives Epithelial-to-Mesenchymal Transition, Immune Evasion, and Anti-PD-1 Resistance through Coordinated Upregulation of Wnt Ligands and PGE2 Synthesis Nicholas C. DeVito, MD; Michael Sturdivant; Balamayooran BT. Theivanthiran, PhD; Y-Van Nguyen; Michael P. Plebanek, PhD; Brent A. Hanks, MD, PhD Tumor and Stromal Cell Biology Antigen presenting cells;Checkpoint blockade;Dendritic cell;Gene expression;Immune suppression;MDSC;NK/NKT cell;Solid tumors;Tumor evasion;Tumor microenvironment
924 Poster Presentation The Spatial Hierarchy of Primary and Recurrent Medulloblastoma Tumor Ecosystems Laura K. Donovan, PhD; Bei Hopkins; Ben Draper; Rivani Shah; Kristin Roman; Bethany Remeniuk, PhD Tumor and Stromal Cell Biology Immune suppression;Monocyte/Macrophage;Pediatric tumors;T cell;Tumor microenvironment
925 Poster Presentation Utilizing multiplex immunofluorescence to explore the epithelial-mesenchymal transition in breast, ovarian cancers Danielle M. Fails, MS; Michael L. Spencer, PhD Tumor and Stromal Cell Biology Antibody;Biomarkers;Immune monitoring;T cell;Tumor infiltrating lymphocytes (TILs);Tumor microenvironment
926 Poster Presentation Immune profiling of KEAP1-deficient NSCLC: development of therapeutic strategies to overcome resistance to immunotherapy Ana Galan-Cobo, PhD; Yu Qian, PhD; Fuduan Peng, PhD; Daniel J. McGrail, PhD; Fahao Zhang; Xiang Zhang; Edwin R. Parra, MD, PhD; Minghao Dang; Saxon Rodriguez; Alexandre Reuben, PhD; Ignacio Wistuba, MD; Ferdinandos Skoulidis; Linghua Wang, PhD; John V. Heymach, MD, PhD Tumor and Stromal Cell Biology Biomarkers;Checkpoint blockade;Tumor microenvironment
927 Poster Presentation Wilms tumor reveals DNA repair gene hyper-expression is linked to lack of immune infiltration Emily Higgs; Riyue Bao, PhD; Ken Hatogai, MD PhD; Thomas F. Gajewski, MD, PhD Tumor and Stromal Cell Biology Bioinformatics;Gene expression;Immunoscore;Inflammation;Pediatric tumors;RNA;Tumor evasion;Tumor microenvironment
928 Poster Presentation A translational approach to catalog pancreatic cancer heterogeneity using spatial genomics in large patient cohorts for target validation and rational combination selection Omar J. Jabado, PhD; Li Fan; Patricia Coutinho de Souza, DVM, PhD; Angelo Harris; Arturo Chaparro; Mohammed Qutaish, PhD; Han Si, PhD; Jan-Hermen Dannenberg, PhD; Kate Sasser, PhD; Suzana Couto; Mark Fereshteh, PhD Tumor and Stromal Cell Biology Bioinformatics;Bispecifics;Gene expression;Immune contexture;Monocyte/Macrophage;Solid tumors;Systems biology;T cell;Tumor infiltrating lymphocytes (TILs);Tumor microenvironment
929 Poster Presentation Dissecting intratumoral immune organization: defining the comparative cellular composition of tertiary lymphoid structures T-cell supportive antigen presenting niches in renal tumors Caroline S. Jansen, BS; Ewelina Sobierajska; Rachel Greenwald; Jennifer Carlisle, MD; Patrick Mullane, MD; Nataliya Prokhnevska, BS; Maria Cardenas; Mehmet A. Bilen, MD; Adeboye O. Osunkoya, MD; Viraj Master, Dr.; Haydn T. Kissick, PhD Tumor and Stromal Cell Biology Antigen presenting cells;Dendritic cell;Immune contexture;Myeloid cells;Solid tumors;T cell;T cell lineages;Tumor infiltrating lymphocytes (TILs);Tumor microenvironment;Tumor stroma
930 Poster Presentation Fibroblast activation protein alpha expression in tumor stroma and its association with immuno-regulatory circuits across epithelial tumors Anton Kraxner; Franziska Braun; Wei-Yi Cheng; Marta Canamero; Emilia Andersson; Suzana Vega Harring; Sebastian Dziadek; Ann-Marie Broeske; Maurizio Ceppi; Volker Teichgraeber; Jehad Charo Tumor and Stromal Cell Biology Biomarkers;Immune contexture;Inflammation;Tumor infiltrating lymphocytes (TILs);Tumor microenvironment;Tumor stroma
931 Poster Presentation LncRNA Malat1 Regulated Serpinb6b Signaling Suppresses Pyroptosis and Governs Breast Cancer Dormancy Reactivation and Through Immune Evasion Dhiraj Kumar, PhD; Filippo Giancotti, MD, PhD Tumor and Stromal Cell Biology Checkpoint blockade;MDSC;RNA;T cell;Tumor microenvironment;Tumor stroma
933 Poster Presentation Immune infiltrates differences between central and periphery regions of colorectal and pancreas adenocarcinomas Andreia Maia, PhD candidate; Joana R. Lérias, DVM, PhD; Luis Miguel Borrego, MD, PhD; Markus J. Maeurer, MD, PhD, FRCP(London); Mireia Castillo-Martin, MD, PhD Tumor and Stromal Cell Biology Adoptive immunotherapy;B cell;NK/NKT cell;Regulatory T cell (Treg cell);Solid tumors;T cell;Tumor infiltrating lymphocytes (TILs);Tumor microenvironment;Tumor stroma
934 Poster Presentation Biological mechanisms in the different etiologies of Merkel cell carcinoma patients: polyomavirus or UV exposure Domenico Mallardo, MD; Giosuè Scognamiglio; Khrystyna North; Mariaelena Capone, MD; Michael Bailey; Luigi Scarpato; Sarah E. Church, PhD; Gabriele Madonna, MS; Jason W. Reeves, PhD; Marcello Curvietto; Marilena Tuffanelli; grazia d'angelo; Ester Simeone, MD; Lucia Festino; Vito Vanella; Claudia Trojaniello; Maria Grazia Vitale, MD; Salvatore Tafuto; Corrado Caracò; Anna Maria Anniciello; Nicola Normanno; Maurizio Di Bonito; Sarah E. Warren, PhD; Paolo A. Ascierto, MD Tumor and Stromal Cell Biology Biomarkers;Carcinogenesis;Gene expression;Immune monitoring;Immune suppression;T cell;Tumor evasion;Tumor infiltrating lymphocytes (TILs);Tumor microenvironment;Tumor stroma
935 Poster Presentation Attraction of immune cells by head and neck cancer cell lines and primary tumor-conditioned supernatants Tara Muijlwijk, MSc; Naomi Remkes; Jos B. Poell, Dr.; René C. Leemans, Prof. dr.; Ruud H. Brakenhoff, Prof. dr.; Rieneke van de Ven, Dr. Tumor and Stromal Cell Biology Chemokine;Dendritic cell;Immune contexture;Immune monitoring;Monocyte/Macrophage;Myeloid cells;Solid tumors;Tumor infiltrating lymphocytes (TILs);Tumor microenvironment
936 Oral Presentation Stromal remodeling regulates dendritic cell abundance in the tumor microenvironment Athanasios Papadas, MD; Gauri Deb; Adam Officer; Chelsea Hope; Philip Emmerich; Alexander Cicala; Joshua Wiesner; Garrett Arauz; Adam Pagenkopf; Kristina Matkowskyj; Dustin Deming; Katerina Politi, PhD; Scott I. Abrams, PhD; Olivier Harismendy; Fotis Asimakopoulos, MD PhD Tumor and Stromal Cell Biology Antigen presenting cells;Dendritic cell;Glycoproteomics;Immune contexture;Inflammation;Myeloid cells;Tumor evasion;Tumor microenvironment;Tumor stroma;Vaccine
937 Poster Presentation Advanced Understanding of the Tumor Microenvironment with Multiplex Analysis: An automated 7-color multiplex assay using Akoya’s Opal Technology Bhavika Patel, PhD; Stephanie Allen; Tania Eliseeva, MS; Najiba Mammadova, PhD; Agnes Haggerty, PhD; Navi Mehra, PhD Tumor and Stromal Cell Biology Biomarkers;Immune contexture;Immune monitoring;Immune suppression;Solid tumors;Tumor microenvironment;Tumor stroma
938 Poster Presentation Study of the tumor microenvironment of oral squamous cell carcinoma using multiplex immunofluorescence and image analysis approaches Frank Rojas, MD; Jebrane BOUAOUD, MD PhD Student; Edwin R. Parra, MD, PhD; Pierre Saintigny; Auriole Tamegnon; Mei Jiang; Shanyu Zhang; Pandurengan Renganayaki; Lucas Michon; Nicolas Gadot; Sylvie Lantuejoul; Philippe Zrounba; Jean-Philippe Foy; Karene Mahtouk; Chloe Bertolus Tumor and Stromal Cell Biology Biomarkers;Immune suppression;Tumor microenvironment
939 Poster Presentation Autocrine/paracrine factors in cancer associated fibroblasts drive immunosuppression through impaired myeloid cell functions Nikita S. Sharma, PhD; Priya Govindaraju, PhD; Shermineh Bradford, BS; Yarong Wang, BS; Brianna Flynn, MS; Candace Wai Sze Lei; Varenka Rodriguez Di Blasi, PhD; Jeanine Pignatelli, PhD; Kang Liu, PhD; Emily Corse, PhD; Abhishek Kashyap, PhD Tumor and Stromal Cell Biology Antigen presenting cells;Dendritic cell;Immune suppression;Immune tolerance;Inflammation;MDSC;Monocyte/Macrophage;Myeloid cells;Solid tumors;Tumor infiltrating lymphocytes (TILs)
940 Poster Presentation Targeting DKK1 to reverse immunosuppressive macrophages and enhance PD-1 blockade therapy in gastric cancer Tao Shi, PhD; Yipeng Zhang; Yue Wang; Yunfeng Pan; Hanbing Wang; Yuting Luo; Kaijie Liang; Fangcen Liu; Qin Liu; Keying Che; Xuan Wang; Lixia Yu; Baorui Liu, PhD MD; Jia Wei, MD PhD Tumor and Stromal Cell Biology Monocyte/Macrophage;NK/NKT cell;T cell;Tumor microenvironment
941 Poster Presentation Stromal cell sialylation suppresses T cells in inflammatory tumour microenvironments: A new tumour stromal cell immune checkpoint? Oliver Treacy, PhD; Hannah Egan, BSc; Kevin Lynch, PhD; Niamh A. Leonard, MSc; Kim De Veirman, PhD; Karin Vanderkerken, Prof.; Laurence Egan, Prof; Thomas Ritter, Prof; Aisling M. Hogan, MD; Keara Redmond, PhD; Janusz Krawczyk, MD; Sean Hynes, PhD; Emma Kerr, PhD; Philip D. Dunne, PhD; Michael E. O'Dwyer, Prof.; Aideen E. Ryan, PhD Tumor and Stromal Cell Biology Solid tumors;Tumor microenvironment;Tumor stroma
942 Poster Presentation The tumor microbiome correlates with response to immune checkpoint inhibitors in renal cell carcinoma Caroline Wheeler; Yuanquan Yang, MD, PhD; Daniel Spakowicz, PhD, MS; Rebecca Hoyd; Mingjia Li, MD Tumor and Stromal Cell Biology Microbiome;RNA;Tumor microenvironment
943 Poster Presentation 3D in vitro tumor model platform rapidly assays immunotherapy efficacy with high content imaging and downstream phenotypic changes with flow cytometry and cytokine analysis Bin Xue, PhD; Julia Schuler, DVM PhD; Christopher M. Harrod; Kolin C. Hribar, PhD Tumor and Stromal Cell Biology Immune suppression;T cell;Tumor microenvironment;Tumor stroma
944 Poster Presentation Fibroblasts as paracrine targets of the oncometabolite D-2-HG in the IDH1-mutant cholangiocarcinoma tumor microenvironment Daniel Zabransky, MD, PhD; Prerna Jain; Kabir Mody, MD; Sherif El-Refai, PhamD, PhD; Elizabeth M. Jaffee, MD; Mark Yarchoan, MD Tumor and Stromal Cell Biology Gene expression;Solid tumors;Targeted therapy;Tumor microenvironment;Tumor stroma