Skip to Late-Breaking Abstracts »
All accepted abstracts will be available in the Journal for ImmunoTherapy of Cancer (JITC).
Onsite posters will be presented in the Poster Hall at the Walter E. Washington Convention Center in Washington, D.C. All odd numbered posters will be presented on Friday, Nov. 12, 2021. Even numbered posters will be presented Saturday, Nov. 13, 2021.
ePosters will be on display on the SITC 2021 virtual meeting platform from 7 a.m. EST on Friday, Nov. 12, 2021 until the virtual meeting platform is closed on Jan. 9, 2022.
# | Type | Title | Authors | Category | Keywords |
---|---|---|---|---|---|
638 | Poster Presentation | Hypoxia reprograms natural killer cells and impairs their therapeutic potential | Philippa R. Kennedy; Upasana Sunil Arvindam; Brianna Ettestad; Shee Kwan Phung; Quinlan Kile; Peter Hinderlie; Yunmin Li; James Lim; Jeffrey S. Miller, MD; Martin Felices, PhD | Immune Cell Biology | Epigenetics;Gene expression;Immune suppression;Metabolism;NK/NKT cell;Solid tumors;Tumor infiltrating lymphocytes (TILs);Tumor microenvironment |
639 | Poster Presentation | PIK3IP1/TrIP Immune Regulation on CD8+ T Cells Restricts Anti-Tumor Immunity | Benjamin M. Murter, BS; Hridesh d. Banerjee, PhD; Andrea L. Szymczak-workman, PhD; Lawrence P. Kane, PHD | Immune Cell Biology | Solid tumors;T cell;Tumor infiltrating lymphocytes (TILs);Tumor microenvironment |
640 | Poster Presentation | Stem-like CD4 T cells in cancer | Maria Cardenas; Nataliya Prokhnevska, BS; Caroline S. Jansen, BS; Viraj Master, Dr.; Haydn T. Kissick, PhD | Immune Cell Biology | Regulatory T cell (Treg cell);T cell;T cell lineages;Tumor infiltrating lymphocytes (TILs) |
641 | Poster Presentation | Spatially organized multicellular immune hubs in MMRd and MMRp colorectal cancer. | Jonathan H. Chen, MD/PhD; Karin Pelka, PhD; Matan Hofree, PhD; Marios Giannakis, MD, PhD; Genevieve Boland, PhD; Andrew Aguirre, MD, PhD; Ana C. Anderson, PhD; Orit Rozenblatt-Rosen, PhD; Aviv Regev, PhD; Nir Hacohen, PhD | Immune Cell Biology | Immune contexture;Monocyte/Macrophage;Myeloid cells;Solid tumors;Systems biology;T cell;Tumor evasion;Tumor infiltrating lymphocytes (TILs);Tumor microenvironment;Tumor stroma |
642 | Poster Presentation | Decreased host PKC-delta is associated with the T cell-inflamed tumor microenvironment and improves anti-tumor immunity | Kyle R. Cron, B.S, B.A; Ayelet S. Sivan; Keston Aquino-Michaels, PhD; Emily Higgs; Jessica L. Fessler, BS; Seoho Lee; Randy F. Sweis, MD; Thomas F. Gajewski, MD, PhD | Immune Cell Biology | Autoimmunity;Checkpoint blockade;Gene expression;Genetic polymorphism;Immunoscore;Inflammation;Monocyte/Macrophage;Myeloid cells;Solid tumors |
643 | Poster Presentation | Vasoactive intestinal peptide as a novel immune checkpoint molecule in activated T cells | Sruthi Ravindranathan, PhD, MS; Tenzin Passang Fnu, Bachelor of Arts; Edmund K. Waller, MD/PHD | Immune Cell Biology | Checkpoint blockade;Chemokine;Immune suppression;Solid tumors;T cell;Tumor evasion;Tumor microenvironment |
644 | Poster Presentation | Tumor-mediated suppressive signaling and hypoxia supports altered chromatin landscapes that limit the transcriptional and functional potential of terminal T cell exhaustion | Rhodes Ford, BSc; Natalie Rittenhouse; Nicole E. Scharping, PhD; Paolo DA. Vignali, BA; Greg M. Delgoffe, PhD; Amanda Poholek | Immune Cell Biology | Bioinformatics;Epigenetics;Gene expression;Metabolism;T cell;Tumor infiltrating lymphocytes (TILs);Tumor microenvironment |
645 | Poster Presentation | Single-cell transcriptional and clonal characterization of CD4+ T cells across tissues in long-term melanoma survivors | Jichang Han, BS; Yanding Zhao; Keisuke Shirai, MD, MS; Tyler G. Searles; Nikhil Khatwani; Jennifer L. Vella; Fatima S. Haidar; Fred W. Kolling; Jiang Gui; Chao Cheng; Mary J. Turk; Christina V. Angeles, MD | Immune Cell Biology | Autoimmunity;Bioinformatics;Checkpoint blockade;Clinical study;Solid tumors;T cell;T cell lineages;Tumor infiltrating lymphocytes (TILs);Tumor microenvironment |
646 | Poster Presentation | Transcriptome analysis of tumor and matched infiltrating lymphocytes identifies potential new targets for augmenting intra-tumoral NK function in soft tissue sarcomas | Sean J. Judge, MD, MS; Joshua Bloomstein, BS; Sylvia M. Cruz, BS; Aryana M. Razmara, MS; Cyrus J. Sholevar, MD; Robert J. Canter, MD, MAS, FACS | Immune Cell Biology | NK/NKT cell;Tumor infiltrating lymphocytes (TILs);Tumor microenvironment |
647 | Poster Presentation | Possibility of immunotherapy for the glioblastoma patients with O6-methyl-guanine DNA methyltransferase (MGMT) expression or promoter unmethylated. | Yoshihiro Kushihara; Yukari Kobayashi, BS; Koji Nagaoka, PhD; Kazuhiro Kakimi, MD, PhD | Immune Cell Biology | Immune suppression;T cell;Tumor infiltrating lymphocytes (TILs);Tumor microenvironment |
648 | Poster Presentation | T cell intrinsic caspase 1 signaling negatively regulates T cell anti-tumor response | Cara Lang, B.S.; Young J. Kim, MD, PhD; Michael J. Korrer, PhD | Immune Cell Biology | Checkpoint blockade;Inflammation;T cell;Tumor microenvironment |
649 | Poster Presentation | Efferocytosis drives myeloid inflammasome signaling and Gasdermin D independent secretion of IL-1β to promote tumor growth | Sohini Roy, PhD; Cara Lang, B.S.; Yu Wang; Diana K. Graves, B.S.; Xu Yaomin; Young J. Kim, MD, PhD | Immune Cell Biology | Immune tolerance;MDSC;Monocyte/Macrophage;Solid tumors |
650 | Poster Presentation | Target the activin receptor 1c on CD4+ T cells to achieve anti-tumor therapeutic effects | Ying Zheng, Ph.D.; Andriana Lebid; Andrew M. Pardoll, MD, PhD; Juan Fu; Chirag H. Patel, PhD; Xiaoxu Wang | Immune Cell Biology | Antibody;Regulatory T cell (Treg cell);T cell;Tumor infiltrating lymphocytes (TILs);Tumor microenvironment |
651 | Oral Presentation | Molecular signature of neoantigen-reactive CD4+ and CD8+ T cells from metastatic human cancers enables prospective antitumor TCR prediction | Frank J. Lowery, III, Ph.D.; Sri Krishna, PhD; Rami Yoseph, PhD; Neilesh B. Parikh, M.D.; Praveen D. Chatani, MD; Yong-Chen William W. Lu, PhD; Nikolaos Zacharakis, PhD, MS; Paul F. Robbins, PhD; Maria Parkhurst, PhD; Steven A. Rosenberg, MD, PhD | Immune Cell Biology | Adoptive immunotherapy;Neoantigens;Solid tumors;T cell;Tumor antigens;Tumor infiltrating lymphocytes (TILs) |
652 | Poster Presentation | Anti-PD-L1/IL-15 KD033 activated macrophages and induced anti-tumor immunity in the tumor-microenvironment | Stella Martomo, PhD; George Wang; Zhanna Polonskaya; Xenia Luna; Dan Lu, MS; Jeegar Patel | Immune Cell Biology | Bispecifics;Checkpoint blockade;Monocyte/Macrophage;Tumor microenvironment |
653 | Poster Presentation | The immune landscape of primary and recurrent adolescent and young adult bone sarcomas | Anthony R. Cillo, PhD; Elina Mukherjee; Jessica D. Daley; Sayali Onkar; Xiang Li; Dongyan Liu; Dario A. Vignali, PhD; Tullia C. Bruno, PhD; Kelly M. Bailey, MD, PhD | Immune Cell Biology | Bioinformatics;Gene expression;Monocyte/Macrophage;Pediatric tumors;Solid tumors;Systems biology;Tumor microenvironment |
654 | Poster Presentation | Analysis of IDO-1 expression on dendritic cells and factors influencing its up- and downregulation in pancreatic cancer. | Michael A. Hollingsworth, PhD; Kamiya Mehla, PhD; Kirsten C. Eberle, PhD; Ying C. Huang, PhD; Aleata C. Triplett, MS; Paul C. Grandgenett, PhD; Thomas C. Caffrey, MS; Clara S. Mundry, Pharmacist | Immune Cell Biology | Antigen presenting cells;Dendritic cell;Extracellular vesicles/exosomes;Immune suppression;Immune tolerance;Solid tumors;Tumor antigens;Tumor microenvironment |
655 | Oral Presentation | Landscape of helper and regulatory CD4+ T cells in melanoma | Giacomo Oliveira, PhD; Kari Stromhaug; Susan Klaeger; Nicoletta Cieri; Bryan Iorgulescu, MD; Shuqiang Li, PhD; David A. Braun; Donna Neuberg; Steven A. Carr; Kenneth J. Livak; Dennie F. Tompers; Edward F. Fritsch; Megan Wind-Rotolo, PhD; Nir Hacohen, PhD; Moshe Sade-Feldman; Derin B. Keskin, MD PhD; Patrick A. Ott, MD, PhD; Scott J. Rodig, MD, PhD; Genevive M. Boland, MD, PhD; Catherine J. Wu, MD | Immune Cell Biology | Immune suppression;Neoantigens;Solid tumors;T cell;T cell lineages;Tumor antigens;Tumor evasion;Tumor infiltrating lymphocytes (TILs);Tumor microenvironment |
657 | Poster Presentation | Characterization and Therapeutic Targeting of a Tumor-associated Tolerogenic DC Subpopulation Driven by SREBP2 and the Mevalonate Metabolic Pathway | Michael P. Plebanek, PhD; Nicholas C. DeVito, MD; Fang Liu, M.D.; Balamayooran BT. Theivanthiran, PhD; Georgia M. Beasley, MD, MHs; Brent A. Hanks, MD, PhD | Immune Cell Biology | Antigen presenting cells;Dendritic cell;Immune suppression;Immune tolerance;Metabolism;Myeloid cells;Tumor evasion;Tumor microenvironment |
658 | Oral Presentation | CD8 T cell activation in cancer is comprised of two distinct phases | Nataliya Prokhnevska, BS; Maria Cardenas; Rajesh M. Valanparambil, PhD; Ewelina Sobierajska, BS; Caroline S. Jansen, BS; Viraj Master, Dr.; Martin Sanda, Dr.; Haydn T. Kissick, PhD | Immune Cell Biology | Antigen presenting cells;Costimulation;Dendritic cell;T cell;T cell lineages |
659 | Poster Presentation | T cell receptor exchange by zygote engineering results in physiological T cell responses for therapeutic use in pancreatic ductal adenocarcinoma | Meagan R. Rollins, BA; Jackson F. Raynor; Ebony A. Miller; Ellen J. Spartz, M.D.; Walker S. Lahr; Adam L. Burrack, Ph.D.; Yun You, Ph.D.; Branden S. Morarity, Ph.D.; Beau R. Webber, PhD; Ingunn M. Stromnes, Ph.D. | Immune Cell Biology | Adoptive immunotherapy |
660 | Oral Presentation | Targeting T cell fates: converting exhaustion to memory to improve immunotherapeutic responses to cancer | Nicole E. Scharping, PhD; Allison Cafferata; Maximilian Heeg; Quynhanh Nguyen; Ananda W. Goldrath | Immune Cell Biology | Adoptive immunotherapy;Checkpoint blockade;Solid tumors;T cell;T cell lineages;Targeted therapy;Tumor infiltrating lymphocytes (TILs) |
661 | Poster Presentation | Neoantigen-specific CD4+ T cells in human melanoma have diverse differentiation states and correlate with CD8+ T cell, macrophage, and B cell function | Joshua R. Veatch, MD, PhD; Naina Singhi; Carolyn Shasha; Sylvia Lee, MD; Julia Szeto; Ata S. Moshiri, MD, MPH; Teresa Kim, MD; John A. Thompson, MD; Scott S. Tykodi, MD, PhD; Venu G. Pillarisetty, MD; David R. Byrd; Kimberly S. Smythe, BS; Shailender Bhatia, MD; Evan T. Hall, MD, MPhil; Evan W. Newell, PhD; Raphael Gottardo, PhD; Stanley R. Riddell, MD | Immune Cell Biology | Neoantigens;T cell;Tumor antigens;Tumor infiltrating lymphocytes (TILs) |
662 | Poster Presentation | Dissecting the CD226 immune axis in the tumor microenvironment using CyTOF-based high-dimensional immunophenotyping | Katie Vowell, PhD; Michael Conner; Florence Perrin; Paul Bojczuk; Kenneth Hance, PhD, MPH; Iris Roth, PhD; Christine Donahue, PhD; James Smothers, PhD; Jeremy Waight, PhD | Immune Cell Biology | Checkpoint blockade;NK/NKT cell;Solid tumors;T cell;Tumor infiltrating lymphocytes (TILs);Tumor microenvironment |
663 | Oral Presentation | Media based on the metabolic composition of tumor interstitial fluid reveals persistent T cell dysfunction induced through arginine deprivation and exposure to the oncometabolite phosphoethanolamine | Yupeng Wang, BD; Chufan Cai; Dayana Rivadeneira, PhD; Alexander Muir; Greg M. Delgoffe, PhD | Immune Cell Biology | Metabolism;Solid tumors;T cell;Tumor microenvironment |
664 | Oral Presentation | Pulmonary priming of tumor-reactive CD8+ T cells by DC1 is impaired by regulatory T cells | Maria Zagorulya, B.S.; Duncan Morgan; Leon Yim; Brendan L. Horton, PhD; Elen Torres-Mejia, PhD; Stefani Spranger, PhD | Immune Cell Biology | Antigen presenting cells;Checkpoint blockade;Dendritic cell;Immune suppression;Immune tolerance;Regulatory T cell (Treg cell);Solid tumors;T cell;T cell lineages |
665 | Poster Presentation | Transcriptional landscape of tumor-reactive TIL in lung cancer and melanoma | Jiajia Zhang, MD, MPH; Justina Caushi; Boyang Zhang; Zhicheng Ji; Taibo Li; Hongkai Ji; Andrew M. Pardoll, MD, PhD; Kellie Smith | Immune Cell Biology | Checkpoint blockade;Neoantigens;T cell;Tumor antigens;Tumor infiltrating lymphocytes (TILs) |
666 | Poster Presentation | Deletion of Drp1 in T cells increases OXPHOS and CD8+ memory T cell population | Timothy N. Bullock, PhD; Marissa Gonzales, BS | Immune Cell Biology | Metabolism;Solid tumors;T cell;Tumor infiltrating lymphocytes (TILs) |
667 | Poster Presentation | Tumor-derived alpha-fetoprotein requires polyunsaturated fatty acids for immuno-metabolic dysregulation | Paul V. Munson, PhD; Juraj Adamik, PhD; Lisa H. Butterfield, PhD | Immune Cell Biology | Antigen presenting cells;Dendritic cell;Gene expression;Immune suppression;Metabolism;Monocyte/Macrophage;Tumor evasion |
668 | Oral Presentation | Lipid-instructed metabolic rewiring unleash the anti-tumor potential of CD8+ T cells. | Teresa Manzo, PhD; Carina Nava Lauveson; Teresa Maria Frasconi; Silvia Tiberti; Ignazio Caruana; Luigi Nezi; Philip D. Greenberg, MD | Immune Cell Biology | Adoptive immunotherapy;Metabolism;T cell;Tumor microenvironment |
669 | Poster Presentation | Lactate uptake through MCT11, a novel monocarboxylate transporter, enforces dysfunction in terminally exhausted T cells | Ronal M. Peralta, B.S; Greg M. Delgoffe, PhD | Immune Cell Biology | Metabolism;T cell;Tumor infiltrating lymphocytes (TILs);Tumor microenvironment |
670 | Poster Presentation | Oxidative stress originating in the mitochondria damages telomeres sufficient to drive certain features of T cell dysfunction | Dayana Rivadeneira, PhD; Jess Yana; Sanjana Thosar; Marcel Bruchez; Patricia L. Lynn; Greg M. Delgoffe, PhD | Immune Cell Biology | Metabolism;Solid tumors;T cell;Tumor evasion;Tumor infiltrating lymphocytes (TILs);Tumor microenvironment |
671 | Poster Presentation | Biological Impacts of Standard of Care Chemotherapies on Immune Effector Cells from AML Patients | Dmitry Zhigarev, MD; Alexander W. MacFarlane, PhD; Christina Drenberg, PhD; Reza Nejati, MD; Asya Varshavsky, MD PhD; Kerry S. Campbell, PhD | Immune Cell Biology | Biomarkers;Chemotherapy;Clinical study;Immune monitoring;Immune suppression;Leukemia/Lymphoma;NK/NKT cell;Regulatory T cell (Treg cell);T cell |
672 | Poster Presentation | The effect of ChemoRadioTherapy and Tumor Histology on the Immune Contexture of Tumor-Draining Lymph Nodes in NSCLC | Marieke F. Fransen, PhD; Famke L. Schneiders, MD, PhD; Vinitha Kandiah; Teodora Radonic, MD, PhD; Idris Bahce, MD, PhD; Chris Dickhoff, MD, PhD; Tanja D. de Gruijl, PhD | Immune Cell Biology | Checkpoint blockade;Chemotherapy;Dendritic cell;Immune contexture;Monocyte/Macrophage;Radiotherapy;Surgery;T cell |
673 | Poster Presentation | (Re-) Solving the biology of colorectal cancer onset and progression to improve treatment and prevention | Jessica Roelands, MSc; Manon van der Ploeg; Hao Dang; Lukas Hawinkels; Hans Morreau; Noel F. de Miranda, PhD | Immune Cell Biology | Biomarkers;Carcinogenesis;Gene expression;Immune contexture;Immune monitoring;Immune suppression;Monocyte/Macrophage;Tumor evasion;Tumor microenvironment;Tumor stroma |
674 | Poster Presentation | IL-27 signaling drives a type 1 interferon-like gene expression program of immunoregulatory pathways associated with cancer progression | Jonathan A. Hill, PhD; Devapregasan Moodley; Jing Hua, MD, MS; Kerry F. White; Christine E. Miller; Secil Koseoglu, PhD; Ricard Masia, MD PhD; Benjamin H. Lee, MD PhD; Vito J. Palombella, PhD | Immune Cell Biology | Bioinformatics;Biomarkers;Cytokine;Immune suppression;Myeloid cells;NK/NKT cell;RNA;Systems biology;T cell lineages;Tumor microenvironment |
675 | Poster Presentation | Genomic drivers of large B-cell lymphoma resistance to CD19 CAR-T therapy | Michael D. Jain, M.D., Ph.D.; Bachisio Ziccheddu, Ph.D.; Caroline A. Coughlin, B.S.; Rawan Faramand, M.D.; Anthony J. Griswold, Ph.D.; Kayla M. Reid, M.S.; Ola Landgren, M.D., Ph.D.; Frederick L. Locke, M.D.; Francesco Maura, M.D.; Marco L. Davila, M.D., Ph.D.; Jonathan H. Schatz, M.D. | Immune Cell Biology | B cell;Bioinformatics;Biomarkers;CAR T cells;Immune suppression;Leukemia/Lymphoma;T cell |
676 | Oral Presentation | Altered circulating myeloid states associated with anti-PD-1 resistance induce T cell paralysis in human biliary cancer | Bridget P. Keenan, MD, PhD; Elizabeth E. McCarthy; Arielle Ilano; Hai Yang; Li Zhang, MD PhD; Kathryn Allaire; Zenghua Fan, PhD; Tony Li, BS; David S. Lee; Yang Sun, PhD; Alexander Cheung; Hewitt Chang; Brenna Sheldon; Robin K. Kelley, MD; Chun Jimmie Ye, PhD; Lawrence Fong, MD | Immune Cell Biology | Checkpoint blockade;Clinical study;Immune suppression;Immune tolerance;Monocyte/Macrophage;Myeloid cells;Solid tumors;T cell |
677 | Poster Presentation | Reverse Abscopal Effect: Intertumoral Heterogeneity Suppresses Systemic CD8 T Cell-Mediated Antitumor Immunity and Confers PD-1 Inhibitor Resistance in Synchronous Melanoma | Shuyang S. Qin, M.S; Booyeon J. Han, PhD; Alexander C. Chacon, MD; Alexa D. Melucci, MD; Alyssa R. Williams; Rachel Jewell; Minsoo Kim, PhD; David C. Linehan, MD; Scott A. Gerber, PhD; Peter A. Prieto, MD, MPH | Immune Cell Biology | Checkpoint blockade;Immune suppression;Monocyte/Macrophage;T cell;Tumor evasion;Tumor infiltrating lymphocytes (TILs);Tumor microenvironment |
678 | Poster Presentation | The neonatal Fc receptor is elevated in monocyte-derived immune cells in pancreatic cancer. | Justin Thomas, BS; Molly Torok; Kriti Agrawal; Trang T. Vu; Alyssa MM. Castillo; Min Chen; Bryan Remaily; Kyeongmin Kim; Zhiliang Xie; Samuel K. Kulp; Dwight H. Owen; Mitch A. Phelps; Christopher C. Coss; Thomas A. Mace, PhD | Immune Cell Biology | Dendritic cell;MDSC;Monocyte/Macrophage;Myeloid cells |
679 | Poster Presentation | Tumor hypoxia drives suppressor function in exhausted T cells limiting antitumor immunity | Paolo DA. Vignali, BA; Kristin DePeaux, BS; McLane Watson, BS; Nicole E. Scharping, PhD; Ashley Menk, MS; Greg M. Delgoffe, PhD | Immune Cell Biology | Checkpoint blockade;Immune suppression;Immune tolerance;Metabolism;T cell;Tumor infiltrating lymphocytes (TILs);Tumor microenvironment |
680 | Poster Presentation | Isoforms of Neuropilin-2 Regulate Distinct Macrophage Functions and are Associated with Unique Tumor-associated Macrophages in Murine and Human Breast Cancer | Rajeev Dhupar, MD; Katherine E. Jones, BS; Amy A. Powers, MS; Seth H. Eisenberg; Kai Ding; Fangyuan Chen; Cecile C. Nasarre, PhD; Amanda C. LaRue, PhD; Elizabeth S. Yeh, PhD; James D. Luketich, MD; Adrian Lee; Steffi Oesterreich, PhD; Michael T. Lotze, MD; Robert M. Gemmill, PhD; Adam C. Soloff, PhD | Immune Cell Biology | Antigen presenting cells;Inflammation;Monocyte/Macrophage;Myeloid cells;Tumor microenvironment |
681 | Poster Presentation | An ex vivo 3D tumoroid model of fresh patient tissue (3D-EXplore) to assess the phagocytic activity of tumor resident innate immune cells | Kelly Guzman; Olivia McIntosh; Brittany Bunch, PhD; Jacob Yarinsky; Jared C. Ehrhart, PhD; Soner Altiok, MD, PhD | Immune Cell Biology | Monocyte/Macrophage;Solid tumors;Tumor microenvironment;Tumor stroma |