Abstract Titles

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All accepted abstracts will be available in the Journal for ImmunoTherapy of Cancer (JITC).

Abstract Titles

Onsite Posters

Onsite posters will be presented in the Poster Hall at the Walter E. Washington Convention Center in Washington, D.C. All odd numbered posters will be presented on Friday, Nov. 12, 2021. Even numbered posters will be presented Saturday, Nov. 13, 2021.

ePosters

ePosters will be on display on the SITC 2021 virtual meeting platform from 7 a.m. EST on Friday, Nov. 12, 2021 until the virtual meeting platform is closed on Jan. 9, 2022.


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# Type Title Authors Category Keywords
638 Poster Presentation Hypoxia reprograms natural killer cells and impairs their therapeutic potential Philippa R. Kennedy; Upasana Sunil Arvindam; Brianna Ettestad; Shee Kwan Phung; Quinlan Kile; Peter Hinderlie; Yunmin Li; James Lim; Jeffrey S. Miller, MD; Martin Felices, PhD Immune Cell Biology Epigenetics;Gene expression;Immune suppression;Metabolism;NK/NKT cell;Solid tumors;Tumor infiltrating lymphocytes (TILs);Tumor microenvironment
639 Poster Presentation PIK3IP1/TrIP Immune Regulation on CD8+ T Cells Restricts Anti-Tumor Immunity Benjamin M. Murter, BS; Hridesh d. Banerjee, PhD; Andrea L. Szymczak-workman, PhD; Lawrence P. Kane, PHD Immune Cell Biology Solid tumors;T cell;Tumor infiltrating lymphocytes (TILs);Tumor microenvironment
640 Poster Presentation Stem-like CD4 T cells in cancer Maria Cardenas; Nataliya Prokhnevska, BS; Caroline S. Jansen, BS; Viraj Master, Dr.; Haydn T. Kissick, PhD Immune Cell Biology Regulatory T cell (Treg cell);T cell;T cell lineages;Tumor infiltrating lymphocytes (TILs)
641 Poster Presentation Spatially organized multicellular immune hubs in MMRd and MMRp colorectal cancer. Jonathan H. Chen, MD/PhD; Karin Pelka, PhD; Matan Hofree, PhD; Marios Giannakis, MD, PhD; Genevieve Boland, PhD; Andrew Aguirre, MD, PhD; Ana C. Anderson, PhD; Orit Rozenblatt-Rosen, PhD; Aviv Regev, PhD; Nir Hacohen, PhD Immune Cell Biology Immune contexture;Monocyte/Macrophage;Myeloid cells;Solid tumors;Systems biology;T cell;Tumor evasion;Tumor infiltrating lymphocytes (TILs);Tumor microenvironment;Tumor stroma
642 Poster Presentation Decreased host PKC-delta is associated with the T cell-inflamed tumor microenvironment and improves anti-tumor immunity Kyle R. Cron, B.S, B.A; Ayelet S. Sivan; Keston Aquino-Michaels, PhD; Emily Higgs; Jessica L. Fessler, BS; Seoho Lee; Randy F. Sweis, MD; Thomas F. Gajewski, MD, PhD Immune Cell Biology Autoimmunity;Checkpoint blockade;Gene expression;Genetic polymorphism;Immunoscore;Inflammation;Monocyte/Macrophage;Myeloid cells;Solid tumors
643 Poster Presentation Vasoactive intestinal peptide as a novel immune checkpoint molecule in activated T cells Sruthi Ravindranathan, PhD, MS; Tenzin Passang Fnu, Bachelor of Arts; Edmund K. Waller, MD/PHD Immune Cell Biology Checkpoint blockade;Chemokine;Immune suppression;Solid tumors;T cell;Tumor evasion;Tumor microenvironment
644 Poster Presentation Tumor-mediated suppressive signaling and hypoxia supports altered chromatin landscapes that limit the transcriptional and functional potential of terminal T cell exhaustion Rhodes Ford, BSc; Natalie Rittenhouse; Nicole E. Scharping, PhD; Paolo DA. Vignali, BA; Greg M. Delgoffe, PhD; Amanda Poholek Immune Cell Biology Bioinformatics;Epigenetics;Gene expression;Metabolism;T cell;Tumor infiltrating lymphocytes (TILs);Tumor microenvironment
645 Poster Presentation Single-cell transcriptional and clonal characterization of CD4+ T cells across tissues in long-term melanoma survivors Jichang Han, BS; Yanding Zhao; Keisuke Shirai, MD, MS; Tyler G. Searles; Nikhil Khatwani; Jennifer L. Vella; Fatima S. Haidar; Fred W. Kolling; Jiang Gui; Chao Cheng; Mary J. Turk; Christina V. Angeles, MD Immune Cell Biology Autoimmunity;Bioinformatics;Checkpoint blockade;Clinical study;Solid tumors;T cell;T cell lineages;Tumor infiltrating lymphocytes (TILs);Tumor microenvironment
646 Poster Presentation Transcriptome analysis of tumor and matched infiltrating lymphocytes identifies potential new targets for augmenting intra-tumoral NK function in soft tissue sarcomas Sean J. Judge, MD, MS; Joshua Bloomstein, BS; Sylvia M. Cruz, BS; Aryana M. Razmara, MS; Cyrus J. Sholevar, MD; Robert J. Canter, MD, MAS, FACS Immune Cell Biology NK/NKT cell;Tumor infiltrating lymphocytes (TILs);Tumor microenvironment
647 Poster Presentation Possibility of immunotherapy for the glioblastoma patients with O6-methyl-guanine DNA methyltransferase (MGMT) expression or promoter unmethylated. Yoshihiro Kushihara; Yukari Kobayashi, BS; Koji Nagaoka, PhD; Kazuhiro Kakimi, MD, PhD Immune Cell Biology Immune suppression;T cell;Tumor infiltrating lymphocytes (TILs);Tumor microenvironment
648 Poster Presentation T cell intrinsic caspase 1 signaling negatively regulates T cell anti-tumor response Cara Lang, B.S.; Young J. Kim, MD, PhD; Michael J. Korrer, PhD Immune Cell Biology Checkpoint blockade;Inflammation;T cell;Tumor microenvironment
649 Poster Presentation Efferocytosis drives myeloid inflammasome signaling and Gasdermin D independent secretion of IL-1β to promote tumor growth Sohini Roy, PhD; Cara Lang, B.S.; Yu Wang; Diana K. Graves, B.S.; Xu Yaomin; Young J. Kim, MD, PhD Immune Cell Biology Immune tolerance;MDSC;Monocyte/Macrophage;Solid tumors
650 Poster Presentation Target the activin receptor 1c on CD4+ T cells to achieve anti-tumor therapeutic effects Ying Zheng, Ph.D.; Andriana Lebid; Andrew M. Pardoll, MD, PhD; Juan Fu; Chirag H. Patel, PhD; Xiaoxu Wang Immune Cell Biology Antibody;Regulatory T cell (Treg cell);T cell;Tumor infiltrating lymphocytes (TILs);Tumor microenvironment
651 Oral Presentation Molecular signature of neoantigen-reactive CD4+ and CD8+ T cells from metastatic human cancers enables prospective antitumor TCR prediction Frank J. Lowery, III, Ph.D.; Sri Krishna, PhD; Rami Yoseph, PhD; Neilesh B. Parikh, M.D.; Praveen D. Chatani, MD; Yong-Chen William W. Lu, PhD; Nikolaos Zacharakis, PhD, MS; Paul F. Robbins, PhD; Maria Parkhurst, PhD; Steven A. Rosenberg, MD, PhD Immune Cell Biology Adoptive immunotherapy;Neoantigens;Solid tumors;T cell;Tumor antigens;Tumor infiltrating lymphocytes (TILs)
652 Poster Presentation Anti-PD-L1/IL-15 KD033 activated macrophages and induced anti-tumor immunity in the tumor-microenvironment Stella Martomo, PhD; George Wang; Zhanna Polonskaya; Xenia Luna; Dan Lu, MS; Jeegar Patel Immune Cell Biology Bispecifics;Checkpoint blockade;Monocyte/Macrophage;Tumor microenvironment
653 Poster Presentation The immune landscape of primary and recurrent adolescent and young adult bone sarcomas Anthony R. Cillo, PhD; Elina Mukherjee; Jessica D. Daley; Sayali Onkar; Xiang Li; Dongyan Liu; Dario A. Vignali, PhD; Tullia C. Bruno, PhD; Kelly M. Bailey, MD, PhD Immune Cell Biology Bioinformatics;Gene expression;Monocyte/Macrophage;Pediatric tumors;Solid tumors;Systems biology;Tumor microenvironment
654 Poster Presentation Analysis of IDO-1 expression on dendritic cells and factors influencing its up- and downregulation in pancreatic cancer. Michael A. Hollingsworth, PhD; Kamiya Mehla, PhD; Kirsten C. Eberle, PhD; Ying C. Huang, PhD; Aleata C. Triplett, MS; Paul C. Grandgenett, PhD; Thomas C. Caffrey, MS; Clara S. Mundry, Pharmacist Immune Cell Biology Antigen presenting cells;Dendritic cell;Extracellular vesicles/exosomes;Immune suppression;Immune tolerance;Solid tumors;Tumor antigens;Tumor microenvironment
655 Oral Presentation Landscape of helper and regulatory CD4+ T cells in melanoma Giacomo Oliveira, PhD; Kari Stromhaug; Susan Klaeger; Nicoletta Cieri; Bryan Iorgulescu, MD; Shuqiang Li, PhD; David A. Braun; Donna Neuberg; Steven A. Carr; Kenneth J. Livak; Dennie F. Tompers; Edward F. Fritsch; Megan Wind-Rotolo, PhD; Nir Hacohen, PhD; Moshe Sade-Feldman; Derin B. Keskin, MD PhD; Patrick A. Ott, MD, PhD; Scott J. Rodig, MD, PhD; Genevive M. Boland, MD, PhD; Catherine J. Wu, MD Immune Cell Biology Immune suppression;Neoantigens;Solid tumors;T cell;T cell lineages;Tumor antigens;Tumor evasion;Tumor infiltrating lymphocytes (TILs);Tumor microenvironment
657 Poster Presentation Characterization and Therapeutic Targeting of a Tumor-associated Tolerogenic DC Subpopulation Driven by SREBP2 and the Mevalonate Metabolic Pathway Michael P. Plebanek, PhD; Nicholas C. DeVito, MD; Fang Liu, M.D.; Balamayooran BT. Theivanthiran, PhD; Georgia M. Beasley, MD, MHs; Brent A. Hanks, MD, PhD Immune Cell Biology Antigen presenting cells;Dendritic cell;Immune suppression;Immune tolerance;Metabolism;Myeloid cells;Tumor evasion;Tumor microenvironment
658 Oral Presentation CD8 T cell activation in cancer is comprised of two distinct phases Nataliya Prokhnevska, BS; Maria Cardenas; Rajesh M. Valanparambil, PhD; Ewelina Sobierajska, BS; Caroline S. Jansen, BS; Viraj Master, Dr.; Martin Sanda, Dr.; Haydn T. Kissick, PhD Immune Cell Biology Antigen presenting cells;Costimulation;Dendritic cell;T cell;T cell lineages
659 Poster Presentation T cell receptor exchange by zygote engineering results in physiological T cell responses for therapeutic use in pancreatic ductal adenocarcinoma Meagan R. Rollins, BA; Jackson F. Raynor; Ebony A. Miller; Ellen J. Spartz, M.D.; Walker S. Lahr; Adam L. Burrack, Ph.D.; Yun You, Ph.D.; Branden S. Morarity, Ph.D.; Beau R. Webber, PhD; Ingunn M. Stromnes, Ph.D. Immune Cell Biology Adoptive immunotherapy
660 Oral Presentation Targeting T cell fates: converting exhaustion to memory to improve immunotherapeutic responses to cancer Nicole E. Scharping, PhD; Allison Cafferata; Maximilian Heeg; Quynhanh Nguyen; Ananda W. Goldrath Immune Cell Biology Adoptive immunotherapy;Checkpoint blockade;Solid tumors;T cell;T cell lineages;Targeted therapy;Tumor infiltrating lymphocytes (TILs)
661 Poster Presentation Neoantigen-specific CD4+ T cells in human melanoma have diverse differentiation states and correlate with CD8+ T cell, macrophage, and B cell function Joshua R. Veatch, MD, PhD; Naina Singhi; Carolyn Shasha; Sylvia Lee, MD; Julia Szeto; Ata S. Moshiri, MD, MPH; Teresa Kim, MD; John A. Thompson, MD; Scott S. Tykodi, MD, PhD; Venu G. Pillarisetty, MD; David R. Byrd; Kimberly S. Smythe, BS; Shailender Bhatia, MD; Evan T. Hall, MD, MPhil; Evan W. Newell, PhD; Raphael Gottardo, PhD; Stanley R. Riddell, MD Immune Cell Biology Neoantigens;T cell;Tumor antigens;Tumor infiltrating lymphocytes (TILs)
662 Poster Presentation Dissecting the CD226 immune axis in the tumor microenvironment using CyTOF-based high-dimensional immunophenotyping Katie Vowell, PhD; Michael Conner; Florence Perrin; Paul Bojczuk; Kenneth Hance, PhD, MPH; Iris Roth, PhD; Christine Donahue, PhD; James Smothers, PhD; Jeremy Waight, PhD Immune Cell Biology Checkpoint blockade;NK/NKT cell;Solid tumors;T cell;Tumor infiltrating lymphocytes (TILs);Tumor microenvironment
663 Oral Presentation Media based on the metabolic composition of tumor interstitial fluid reveals persistent T cell dysfunction induced through arginine deprivation and exposure to the oncometabolite phosphoethanolamine Yupeng Wang, BD; Chufan Cai; Dayana Rivadeneira, PhD; Alexander Muir; Greg M. Delgoffe, PhD Immune Cell Biology Metabolism;Solid tumors;T cell;Tumor microenvironment
664 Oral Presentation Pulmonary priming of tumor-reactive CD8+ T cells by DC1 is impaired by regulatory T cells Maria Zagorulya, B.S.; Duncan Morgan; Leon Yim; Brendan L. Horton, PhD; Elen Torres-Mejia, PhD; Stefani Spranger, PhD Immune Cell Biology Antigen presenting cells;Checkpoint blockade;Dendritic cell;Immune suppression;Immune tolerance;Regulatory T cell (Treg cell);Solid tumors;T cell;T cell lineages
665 Poster Presentation Transcriptional landscape of tumor-reactive TIL in lung cancer and melanoma Jiajia Zhang, MD, MPH; Justina Caushi; Boyang Zhang; Zhicheng Ji; Taibo Li; Hongkai Ji; Andrew M. Pardoll, MD, PhD; Kellie Smith Immune Cell Biology Checkpoint blockade;Neoantigens;T cell;Tumor antigens;Tumor infiltrating lymphocytes (TILs)
666 Poster Presentation Deletion of Drp1 in T cells increases OXPHOS and CD8+ memory T cell population Timothy N. Bullock, PhD; Marissa Gonzales, BS Immune Cell Biology Metabolism;Solid tumors;T cell;Tumor infiltrating lymphocytes (TILs)
667 Poster Presentation Tumor-derived alpha-fetoprotein requires polyunsaturated fatty acids for immuno-metabolic dysregulation Paul V. Munson, PhD; Juraj Adamik, PhD; Lisa H. Butterfield, PhD Immune Cell Biology Antigen presenting cells;Dendritic cell;Gene expression;Immune suppression;Metabolism;Monocyte/Macrophage;Tumor evasion
668 Oral Presentation Lipid-instructed metabolic rewiring unleash the anti-tumor potential of CD8+ T cells. Teresa Manzo, PhD; Carina Nava Lauveson; Teresa Maria Frasconi; Silvia Tiberti; Ignazio Caruana; Luigi Nezi; Philip D. Greenberg, MD Immune Cell Biology Adoptive immunotherapy;Metabolism;T cell;Tumor microenvironment
669 Poster Presentation Lactate uptake through MCT11, a novel monocarboxylate transporter, enforces dysfunction in terminally exhausted T cells Ronal M. Peralta, B.S; Greg M. Delgoffe, PhD Immune Cell Biology Metabolism;T cell;Tumor infiltrating lymphocytes (TILs);Tumor microenvironment
670 Poster Presentation Oxidative stress originating in the mitochondria damages telomeres sufficient to drive certain features of T cell dysfunction Dayana Rivadeneira, PhD; Jess Yana; Sanjana Thosar; Marcel Bruchez; Patricia L. Lynn; Greg M. Delgoffe, PhD Immune Cell Biology Metabolism;Solid tumors;T cell;Tumor evasion;Tumor infiltrating lymphocytes (TILs);Tumor microenvironment
671 Poster Presentation Biological Impacts of Standard of Care Chemotherapies on Immune Effector Cells from AML Patients Dmitry Zhigarev, MD; Alexander W. MacFarlane, PhD; Christina Drenberg, PhD; Reza Nejati, MD; Asya Varshavsky, MD PhD; Kerry S. Campbell, PhD Immune Cell Biology Biomarkers;Chemotherapy;Clinical study;Immune monitoring;Immune suppression;Leukemia/Lymphoma;NK/NKT cell;Regulatory T cell (Treg cell);T cell
672 Poster Presentation The effect of ChemoRadioTherapy and Tumor Histology on the Immune Contexture of Tumor-Draining Lymph Nodes in NSCLC Marieke F. Fransen, PhD; Famke L. Schneiders, MD, PhD; Vinitha Kandiah; Teodora Radonic, MD, PhD; Idris Bahce, MD, PhD; Chris Dickhoff, MD, PhD; Tanja D. de Gruijl, PhD Immune Cell Biology Checkpoint blockade;Chemotherapy;Dendritic cell;Immune contexture;Monocyte/Macrophage;Radiotherapy;Surgery;T cell
673 Poster Presentation (Re-) Solving the biology of colorectal cancer onset and progression to improve treatment and prevention Jessica Roelands, MSc; Manon van der Ploeg; Hao Dang; Lukas Hawinkels; Hans Morreau; Noel F. de Miranda, PhD Immune Cell Biology Biomarkers;Carcinogenesis;Gene expression;Immune contexture;Immune monitoring;Immune suppression;Monocyte/Macrophage;Tumor evasion;Tumor microenvironment;Tumor stroma
674 Poster Presentation IL-27 signaling drives a type 1 interferon-like gene expression program of immunoregulatory pathways associated with cancer progression Jonathan A. Hill, PhD; Devapregasan Moodley; Jing Hua, MD, MS; Kerry F. White; Christine E. Miller; Secil Koseoglu, PhD; Ricard Masia, MD PhD; Benjamin H. Lee, MD PhD; Vito J. Palombella, PhD Immune Cell Biology Bioinformatics;Biomarkers;Cytokine;Immune suppression;Myeloid cells;NK/NKT cell;RNA;Systems biology;T cell lineages;Tumor microenvironment
675 Poster Presentation Genomic drivers of large B-cell lymphoma resistance to CD19 CAR-T therapy Michael D. Jain, M.D., Ph.D.; Bachisio Ziccheddu, Ph.D.; Caroline A. Coughlin, B.S.; Rawan Faramand, M.D.; Anthony J. Griswold, Ph.D.; Kayla M. Reid, M.S.; Ola Landgren, M.D., Ph.D.; Frederick L. Locke, M.D.; Francesco Maura, M.D.; Marco L. Davila, M.D., Ph.D.; Jonathan H. Schatz, M.D. Immune Cell Biology B cell;Bioinformatics;Biomarkers;CAR T cells;Immune suppression;Leukemia/Lymphoma;T cell
676 Oral Presentation Altered circulating myeloid states associated with anti-PD-1 resistance induce T cell paralysis in human biliary cancer Bridget P. Keenan, MD, PhD; Elizabeth E. McCarthy; Arielle Ilano; Hai Yang; Li Zhang, MD PhD; Kathryn Allaire; Zenghua Fan, PhD; Tony Li, BS; David S. Lee; Yang Sun, PhD; Alexander Cheung; Hewitt Chang; Brenna Sheldon; Robin K. Kelley, MD; Chun Jimmie Ye, PhD; Lawrence Fong, MD Immune Cell Biology Checkpoint blockade;Clinical study;Immune suppression;Immune tolerance;Monocyte/Macrophage;Myeloid cells;Solid tumors;T cell
677 Poster Presentation Reverse Abscopal Effect: Intertumoral Heterogeneity Suppresses Systemic CD8 T Cell-Mediated Antitumor Immunity and Confers PD-1 Inhibitor Resistance in Synchronous Melanoma Shuyang S. Qin, M.S; Booyeon J. Han, PhD; Alexander C. Chacon, MD; Alexa D. Melucci, MD; Alyssa R. Williams; Rachel Jewell; Minsoo Kim, PhD; David C. Linehan, MD; Scott A. Gerber, PhD; Peter A. Prieto, MD, MPH Immune Cell Biology Checkpoint blockade;Immune suppression;Monocyte/Macrophage;T cell;Tumor evasion;Tumor infiltrating lymphocytes (TILs);Tumor microenvironment
678 Poster Presentation The neonatal Fc receptor is elevated in monocyte-derived immune cells in pancreatic cancer. Justin Thomas, BS; Molly Torok; Kriti Agrawal; Trang T. Vu; Alyssa MM. Castillo; Min Chen; Bryan Remaily; Kyeongmin Kim; Zhiliang Xie; Samuel K. Kulp; Dwight H. Owen; Mitch A. Phelps; Christopher C. Coss; Thomas A. Mace, PhD Immune Cell Biology Dendritic cell;MDSC;Monocyte/Macrophage;Myeloid cells
679 Poster Presentation Tumor hypoxia drives suppressor function in exhausted T cells limiting antitumor immunity Paolo DA. Vignali, BA; Kristin DePeaux, BS; McLane Watson, BS; Nicole E. Scharping, PhD; Ashley Menk, MS; Greg M. Delgoffe, PhD Immune Cell Biology Checkpoint blockade;Immune suppression;Immune tolerance;Metabolism;T cell;Tumor infiltrating lymphocytes (TILs);Tumor microenvironment
680 Poster Presentation Isoforms of Neuropilin-2 Regulate Distinct Macrophage Functions and are Associated with Unique Tumor-associated Macrophages in Murine and Human Breast Cancer Rajeev Dhupar, MD; Katherine E. Jones, BS; Amy A. Powers, MS; Seth H. Eisenberg; Kai Ding; Fangyuan Chen; Cecile C. Nasarre, PhD; Amanda C. LaRue, PhD; Elizabeth S. Yeh, PhD; James D. Luketich, MD; Adrian Lee; Steffi Oesterreich, PhD; Michael T. Lotze, MD; Robert M. Gemmill, PhD; Adam C. Soloff, PhD Immune Cell Biology Antigen presenting cells;Inflammation;Monocyte/Macrophage;Myeloid cells;Tumor microenvironment
681 Poster Presentation An ex vivo 3D tumoroid model of fresh patient tissue (3D-EXplore) to assess the phagocytic activity of tumor resident innate immune cells Kelly Guzman; Olivia McIntosh; Brittany Bunch, PhD; Jacob Yarinsky; Jared C. Ehrhart, PhD; Soner Altiok, MD, PhD Immune Cell Biology Monocyte/Macrophage;Solid tumors;Tumor microenvironment;Tumor stroma