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All accepted abstracts are available in the Journal for ImmunoTherapy of Cancer (JITC).

Abstract Titles

Poster Presentation Dates

All odd numbered posters will be presented on Wednesday, Nov. 11, from 5:15-5:45 p.m. EST and Friday, Nov. 13, from 4:40-5:10 p.m. EST. Even numbered posters will be presented on Thursday, Nov. 12, from 4:50-5:20 p.m. EST and Saturday, Nov. 14, from 1-1:30 p.m. EST.

Posters will be on display from 8 a.m. on Monday, Nov. 9, until the virtual poster hall closes on December 31, 2020.


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# Type Title Authors Category Keywords
257 Poster Presentation Development of a Diagnostic Platform Which Matches Therapies to the Tumor Microenvironment Dominant Biology Kristen Strand-Tibbitts, PhD; Completed Clinical Trials Angiogenesis; Bioinformatics; Tumor microenvironment; Tumor stroma
258 Poster Presentation Scientific correlatives from LCCC 1525: A Phase II Study of a Priming Dose of Cyclophosphamide Prior to Pembrolizumab to Treat Metastatic Triple Negative Breast Cancer Mark G. Woodcock, MD; Carey K. Anders, MD; Amanda E. Van Swearingen; Dominic T. Moore; Maria J. Sambade; Luz A. Cuaboy; Amy L. Garrett; Karen McKinnon; Kristen Cowens; Dante S. Bortone; Benjamin C. Calhoun; Lisa Carey; Claire Dees; Trevor Jolly; Hyman Muss; Katherine Reeder-Hayes; Rebecca Kaltman; Rachel Jankowitz; Vinay Gudena; Oludamilola Olajide; Charles M. Perou; Benjamin G. Vincent, MD; Jonathan S. Serody, MD; Completed Clinical Trials B cell; Checkpoint blockade; Clinical trial; Gene expression; Regulatory T cell (Treg cell); Solid tumors; T cell; Tumor microenvironment
259 Poster Presentation Phase Ib/II open-label, randomized evaluation of atezolizumab (atezo) + selicrelumab (seli) + gemcitabine+nab-paclitaxel (gem+nabP) or bevacizumab (bev) vs control in MORPHEUS-PDAC, -TNBC and -CRC Gulam A. Manji, MD PhD; Nathan Bahary, MD PhD; Vincent Chung, MD; Florence Dalenc; Michel Ducreux; Carlos A. Gomez-Roca, MD; Seock-Ah Im; Jeremy Kortmansky; Jill Lacy, MD; Neil H. Segal, MD; Olivier Tredan; Olivera Cirovic, MD, PhD; Kelly DuPree; Christelle Lenain; Danny Lu; Lidia Robert; Jeffrey Xu; Xiaosong Zhang, MD PhD; Sung-Bae Kim; Completed Clinical Trials Checkpoint blockade; Chemotherapy; Clinical trial
260 Poster Presentation T Cell Infiltrating Repertoire Diversity is Associated with Enhanced Survival Following Neoadjuvant Therapy in Patients with Resectable Pancreatic Cancer Pranav Murthy, BS; Pragosh Saini; Kira L. Russell, BS; Wenjing Pan, PhD; Daniel Weber, BS; Miranda L. Byrne-Steele, PhD; Jian Han, MD PhD; Viginia Espina, PhD; Lance Liotta, MD, PhD; Herbert J. Zeh III, MD; Nathan Bahary, MD PhD; Aatur D. Singhi, MD PhD; Tullia C. Bruno, PhD; Amer H. Zureikat, MD; Michael T. Lotze, MD; Completed Clinical Trials B cell; Bioinformatics; Biomarkers; Chemotherapy; Immune contexture; Inflammation; Solid tumors; T cell; Tumor infiltrating lymphocytes (TILs); Tumor microenvironment
261 Poster Presentation Association of T-cell–inflamed gene expression profile and PD-L1 status with efficacy of pembrolizumab in patients with esophageal cancer from KEYNOTE-180 Manish A. Shah, MD; Takashi Kojima; Daniel Hochhauser; Peter M. Enzinger, MD; Judith Raimbourg; Antoine Hollebecque, MD; Florian Lordick; Sung-Bae Kim; Masahiro Tajika; Heung Tae Kim; A. Craig Lockhart; Hendrick-Tobias Arkenau; Farid El-Hajbi; Per Pfeiffer; Pooja Bhagia, MBBS, MD; Z. Alexander Cao; Jared Lunceford; Shailaja Suryawanshi; Mark Ayers, PhD; Matt Marton; Ken Kato, MD, PhD; Completed Clinical Trials Antibody; Biomarkers; Checkpoint blockade; Clinical study; Clinical trial; Gene expression; Solid tumors; Tumor microenvironment
262 Poster Presentation Tumoral DKK1 expression correlates with better clinical outcomes in patients with advanced esophagogastric cancer (EGC) treated with DKN-01 Samuel J. Klempner, MD; Michael Kagey, PhD; Cynthia Sirard, MD; Cynthia Sirard, MD; Completed Clinical Trials Antibody; Biomarkers; Clinical trial; RNA; Targeted therapy
263 Poster Presentation Pleiotropic effects of IL-7 in prostate cancer patients receiving Sipuleucel-T vaccination Caroline Duault, PharmD, PhD; Nirasha Ramchurren, PhD; Russell Pachynski, MD; Lawrence Fong, MD; Sean C. Bendall, PhD; Mina Pichavant; Bita Sahaf, PhD; Chihiro Morishima, MD; Leonard D'Amico, PhD; Martin A. Cheever, MD; Steven P. Fling, PhD; Holden T. Maecker, PhD; Completed Clinical Trials Antigen presenting cells; Clinical trial; Costimulation; Cytokine; Immune adjuvant; Immune monitoring; Solid tumors; Vaccine
264 Poster Presentation Correlation of virus-specific CD8+ T cells to clinical response following treatment with Pexa-Vec and Cemiplimab in patients with advanced renal cell carcinoma Myles Dillon, PhD; Lianjie Li, MD PhD; Jeongsook Bang, MS; Nicholas Gaspar, PhD; Jessica Kuhnert, BS; Nathalie M. Fiaschi, PhD; Vladimir Jankovic, MD; Israel Lowy, MD, PhD; Gavin Thurston, PhD; Glenn Kroog, MD; Kyoung Soo Ha, MD; Raquel Deering, PhD; Raquel Deering, PhD; Completed Clinical Trials Biomarkers; Checkpoint blockade; Clinical trial; Cytokine; T cell; Tumor microenvironment; Vaccine
265 Poster Presentation Phase 1b study of avelumab + M9241 (NHS-IL12) in patients with advanced solid tumors: interim analysis results from a urothelial carcinoma (UC) dose-expansion cohort Jean-Laurent Deville; Alain Ravaud; Marco Maruzzo; Theodore S. Gourdin, MD; Michele Maio, MD; Luc Dirix, MD; XiaoZhe Wang; Yulia Vugmeyster; Frank Beier; Jeorg Seebeck; Sarah Chennoufi, MD, PhD; James L. Gulley, MD, PhD; James L. Gulley, MD, PhD; Completed Clinical Trials Antibody; Checkpoint blockade; Clinical trial; Cytokine; Solid tumors
266 Poster Presentation Tumour mutation burden (TMB) and efficacy outcomes in the phase III DANUBE study of advanced urothelial carcinoma (UC) Sophie Wildsmith; Jill Walker, PhD; Anne L’Hernault; Weimin Li; Hannah Bye; Philip He; Feng Xiao; Qu Zhang; Ross Stewart; Melissa de los Reyes, MS; Rajiv G. Raja, PhD; Wendy Levin; Ashok K. Gupta, MD, PhD; Thomas Powles, MBBS, MD, MRCP; Joaquim Bellmunt; Matthew D. Galsky, MD; Alexandra Drakaki, MD,PHD; Michiel van der Heijden, MD; Completed Clinical Trials Biomarkers; Checkpoint blockade; Clinical study; Clinical trial; Solid tumors
267 Poster Presentation Pseudoprogression patterns: Analysis from 2 independent phase-2 studies with immunotherapy for recurrent cervical cancer David M. O'Malley, MD; Waldo Ortuzar Feliu, MD; Isabelle Ray-Coquard, MDPhD; Michael O'Neal; Jerome Alexandre, MD; Julie Cole, MD; Robert Ludwig, MD; Madhavi Nallewar; Jennifer S. Buell, PhD; Remigiusz Kaleta, MD; Anna Wijatyk, MD; Victoria Borisovskaya; Completed Clinical Trials Antibody; Checkpoint blockade; Clinical study; Clinical trial; Immune toxicity; Solid tumors
268 Poster Presentation A phase 1 study of retifanlimab (INCMGA00012), a PD-1 inhibitor, in patients with advanced solid tumors: preliminary results in recurrent MSI-high or dMMR endometrial cancer (POD1UM-101) Dominique Berton-Rigaud; Ignace Vergote; Patricia Pautier; Anna Kryzhanivska, MD; Antoine Angelergues; Deanna Kornacki, PhD; Monika Dudzisz-Sledz; Chuan Tian, PhD; Nawel Bourayou, MD; Frederic Selle; Completed Clinical Trials Antibody; Checkpoint blockade; Clinical trial; Solid tumors
269 Poster Presentation Tumoral and peripheral landscape of Viral- versus Carcinogen-Driven Head and Neck Cancer Tze Heng Tan; Sriram Sridhar; Helen K. Angell, PhD, BSc; Emma Jones; Amelia Raymond; Sophie Willis; Dimitris Polychronopoulos; Alejandro Yovine; Nassim Morsli; Patricia McCoon, PhD; Carl Barrett; Maria L. Ascierto, PhD; Completed Clinical Trials Biomarkers; Cytokine; Gene expression; Immune contexture; Immune monitoring; Tumor microenvironment
270 Poster Presentation A phase II basket trial of dual anti-CTLA-4 and anti-PD-1 blockade in rare tumors (DART) SWOG S1609: the thyroid tumor cohort Young Kwang Chae, MD, MPH, MBA; Megan Othus; Sandip P. Patel, MD; Sarah E. Fenton, MD PhD; Ding Wang, MD; Cristina Rodriguez; Adedayo Onitilo; Ahmad H. Mattour, MD; Igor Rybkin, MD, PhD; Jourdain Hayward; Christine M. McLeod; Helen Chen, MD; Elad Sharon, MD, MPH; Edward Mayerson; Christopher W. Ryan; Melissa Plets, M.S.; Charles D. Blanke; Razelle Kurzrock, MD; Young Kwang Chae, MD, MPH, MBA; Completed Clinical Trials Checkpoint blockade; Clinical trial; Solid tumors
271 Poster Presentation Consistent high-quality dendritic cell vaccines produced post-chemotherapy in patients with acute myeloid leukemia for use in a Phase I/II trial Frauke Schnorfeil; Christiane Geiger, PhD; Iris Bigalke; Dag Josefsen; Yngvar Floisand; Gunnar Kvalheim, MD, PhD; Dolores J. Schendel, PhD; Anna Tafuri; Kai Pinkernell; Completed Clinical Trials Antigen presenting cells; Dendritic cell; Leukemia/Lymphoma; Targeted therapy; Tumor antigens; Vaccine
272 Poster Presentation Use of LioCyx-M, Autologous Hepatitis B Virus (HBV)-Specific T cell receptor (TCR) T-cells, in Advanced HBV-related Hepatocellular Carcinoma (HCC) Fu-Sheng Wang, MD, PhD; Fanping Meng, MD, PhD; Jiehua Jin, PhD; Yuanyuan Li, MD, PhD; Regina Wanju Wong, PhD; Anthony Tanoto Tan, PhD; Tingting Wang, MD, PhD; Antonio Bertoletti, MD; Completed Clinical Trials Adoptive immunotherapy; Clinical trial; T cell
273 Poster Presentation Phase I Study of LioCyx-M, Autologous Hepatitis B Virus (HBV)-Specific T cell receptor (TCR) T-cells, in Recurrent HBV-Related Hepatocellular Carcinoma (HCC) Post-Liver Transplantation Wenjie Chen, MD, PhD; Jintao Cheng, MD; Xiaofang Zheng, BSc; Fan Yang, MD, PhD; Royce Fam, BSc; Sarene Koh, PhD; Lu-En Wai, PhD; Tingting Wang, MD, PhD; Antonio Bertoletti, MD; Qi Zhang, MD, PhD; Completed Clinical Trials Adoptive immunotherapy; Clinical trial; T cell
274 Oral Presentation Tumoral and peripheral immunophenotype of refractory vs relapse to PD-(L)1 blockade in patients with advanced Non-Small Cell Lung Cancer Maria L. Ascierto, PhD; Matthew D. Hellmann, MD; Nathan Standifer; Song L. Wu; Han Si; Chris Morehouse; Marlon C. Rebelatto, DVM, PhD, DACVP; Shaad E. Abedin, MD, FACP; Rajiv G. Raja, PhD; Jean-Charles Soria, MD, PhD; Caroline Germa; Carl Barrett; Completed Clinical Trials B cell; Biomarkers; Checkpoint blockade; Tumor microenvironment
275 Poster Presentation Translational endpoints associated with STK11 mutations in patients with non-squamous NSCLC Song Wu; Nathan Standifer, PhD; Melissa de los Reyes, MS; Micheal Oberst; Rajv Raja; Carl Barrett; Maria L. Ascierto, PhD; Maria L. Ascierto, PhD; Completed Clinical Trials Biomarkers; Checkpoint blockade; Immune suppression; Tumor microenvironment
276 Poster Presentation Prognostic value of tumor size varies by treatment in a meta-analysis of 15 randomized clinical trials in advanced non-small cell lung cancer across immunotherapy, TKI, and chemotherapy regimens Jacqueline Buros, BA; Krzysztof Sakrejda, PhD; Daniel Lee, MS; Eric Novik, MS; Jacqueline Buros, BA; Philip Jewsbury, PhD; Completed Clinical Trials Biomarkers; Checkpoint blockade; Clinical trial
277 Oral Presentation Combined neoadjuvant chemo-immunotherapy therapy achieves superior downstaging of resectable non-small cell lung cancer as compared to chemotherapy, mono or dual immunotherapy Boris Sepesi, MD; Erin M. Corsini; Annikka Weissferdt; Apar Pataer; Mehmet Altan, MD; Mara B. Antonoff, MD; George R. Blumenschein, Jr., MD; Yasir Y. Elamin; Frank Fossella; Bonnie S. Glisson, MD; Wayne Hofstetter; Jonathan Kurie; Xiuning Le, MD, PhD; Cheuk Hong Leung, MS; Heather Lin, MS, PhD; Charles Lu; Reza Mehran; Frank Mott; David Rice; Jack Roth; Ferdinandos Skoulidis; Stephen G. Swisher, MD; Anne Tsao, MD; Ara A. Vaporciyan, MD; Garret Walsh; Jianjun Zhang, MD, PhD; Don L. Gibbons, MD, PhD; John V. Heymach, MD, PhD; Tina Cascone, MD, PhD; Completed Clinical Trials Checkpoint blockade; Chemotherapy; Clinical trial; Solid tumors; Surgery; Targeted therapy
278 Poster Presentation Phase I clinical trial evaluating the safety of ADP-A2M10 SPEAR T-cells in patients with MAGE-A10+ advanced non-small cell lung cancer George R. Blumenschein, Jr., MD; Siddhartha Devarakonda, MD; Melissa L. Johnson, MD; Victor Moreno, PhD, MD; Justin F. Gainor, MD; Martin Edelman, MD; John V. Heymach, MD, PhD; Ramaswamy Govindan, MD; Carlos Bachier, MD; Bernard Doger de Spéville; Matthew J. Frigault, MD, MSc; Anthony J. Olszanski, MD, RPh; Vincent K. Lam; Natalie Hyland; Jean-Marc Navenot, PhD; Svetlana Fayngerts, PhD; Jane Bai; Elliot Norry, MD; Paula M. Fracasso, MD, PhD Completed Clinical Trials Adoptive immunotherapy; Targeted therapy
279 Poster Presentation Durvalumab after chemoradiotherapy for PD-L1 expressing inoperable stage III NSCLC impacts local-regional control and overall survival MD; Lukas Kaesmann, MD; Julian Taugner; Chukwuka Eze; Claus Belka; Farkhad Manapov; Completed Clinical Trials Checkpoint blockade; Clinical trial; Radiotherapy; Solid tumors
280 Poster Presentation Both tumor intrinsic and extrinsic factors contribute to TIL resistance in lung cancer patients Chao Wang, PhD; Jamie Teer; Jiqiang Yao, PhD; Carmen Anadon; David Noyes; Ana Landin; Xiaoqing Yu; Dongliang Du; Zachary Thompson; Bin Fang, PhD; John M. Koomen, PhD; Sungjune Kim, MD PhD; Shari A. Pilon-Thomas, PhD; Dung-Tsa Chen; Jose R. Conejo-Garcia, MD, PhD; Scott J. Antonia, MD PhD; Eric Haura, MD; Ben C. Creelan, MD, MS; Completed Clinical Trials Adoptive immunotherapy; Neoantigens; Solid tumors; Tumor infiltrating lymphocytes (TILs); Tumor antigens
281 Poster Presentation JAVELIN Medley VEGF: phase 2 study of avelumab + axitinib in patients with previously treated non-small cell lung cancer (NSCLC) or treatment naive, cisplatin-ineligible urothelial cancer (UC) Gabriella Galffy, MD; Iwona Lugowska; Elena Poddubskaya; Byoung Chul c. Cho, MD, PhD; Myung-Ju Ahn; Ji-Youn Han, MD, PhD; Wu-Chou Su; Ralph J. Hauke, MD; Stephen Dyar; Dae Ho Lee; Piotr Serwatowski; David Lorente Estelles; Viran Holden; Yu Jung Kim; Vladimir Vladimirov; Zsolt Horvath; Abhimanyu Ghose; Allison Goldman; Alessandra di Pietro; Jing Wang; Danielle Murphy; Mikhail Laskov Completed Clinical Trials Angiogenesis; Antibody; Checkpoint blockade; Clinical trial; Solid tumors; Targeted therapy
282 Poster Presentation Pan-tumor analysis of the association between PD-L1 combined positive score and response to pembrolizumab monotherapy Lingkang Huang; Jared Lunceford, PhD; Junshui Ma; Kenneth Emancipator, MD; Completed Clinical Trials Antibody; Biomarkers; Checkpoint blockade; Clinical study; Clinical trial; Solid tumors
283 Poster Presentation Safety and efficacy signals in the complete phase I study of live biotherapeutic MRx0518 in combination with pembrolizumab in patients refractory to immune checkpoint inhibitors (ICIs) Shubham Pant, MD; Amishi Shah; Pavlos Msaouel, MD, PhD; Matthew T. Campbell, MD; Shi-Ming Tu; Jianjun Gao, MD PhD; George R. Blumenschein, Jr., MD; Frank Mott; Xiuning Le, MD, PhD; Mehmet Altan, MD; Funda Meric-Bernstam, MD; Timothy A. Yap, MD, PhD; Vivek Subbiah, MD; Jordi Rodon; Axel Glasmacher; Imke Mulder; Michael J. Chisamore, PhD; Alexander Stevenson, PhD; Nizar M. Tannir, MD, FACP; Completed Clinical Trials Checkpoint blockade; Clinical study; Clinical trial; Microbiome; Solid tumors; TLR
284 Poster Presentation Real World Data of Sequencing Immune Checkpoint Inhibitors (ICI) after Initial ICI Krishna S. Gunturu, MD; Muhammad A. Awidi, MD; Rojer Ranjit, NP; Brendan Connell, MD; Rachel Carrasquillo; Brigitte Gil; Natalie Dalbo, MD; Lewena Maher; Seanna Reilly; Stephanie McDonald, NP; Philip Tsoukas, MD; Linda Voner, RN; Completed Clinical Trials Checkpoint blockade; Clinical study; Clinical trial; Immune tolerance; Solid tumors
285 Poster Presentation Phase I clinical trial evaluating the safety of ADP-A2M10 in patients with MAGE-A10+ head and neck, melanoma, or urothelial tumors David S. Hong, MD; Marcus O. Butler, MD; Russell Pachynski, MD; Ryan J. Sullivan, MD; Partow Kebriaei; Sarah Boross-Harmer; Matthew J. Frigault, MD, MSc; Ecaterina I. Dumbrava, MD; Amy Sauer; Francine Brophy; Jean-Marc Navenot, PhD; Svetlana Fayngerts, PhD; Jane Bai; Elliot Norry, MD; Paula G. Fracasso Completed Clinical Trials Adoptive immunotherapy; Targeted therapy
286 Poster Presentation Tumor targeting and tissue biodistribution of RO7122290, a novel FAP-targeted 4-1BB (CD137) agonist, in patients with advanced solid tumors, using [89Zr]-RO7122290 as a PET tracer Maria Jose Garcia Velloso; Ivan Penuelas; Mariano Ponz-Sarvise; Miguel Sanmamed; Maria E. Rodriguez-Ruiz, MD, PhD; Ignacio J. Melero, Dr., MD, PhD; Danielle Vugts; Ronald Boellaard; Marc Huisman; Guus van Dongen; Ernesto Guarin; Florian Heil; Maurizio Ceppi, PhD; Marta Canamero, MD, PhD; Camilla Matheisen; Francois Iglesias; Radoiane Helbaj; Oliver Krieter; Michael Hettich; Completed Clinical Trials Bispecifics; Clinical study; Clinical trial; Solid tumors; T cell; Tumor microenvironment; Tumor stroma
287 Poster Presentation Safety and antitumor activity of indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor KHK2455 in combination with anti-CCR4 monoclonal antibody mogamulizumab in patients with advanced solid tumors Solmaz Sahebjam, MD; Jameel Muzaffar, MD; Timothy A. Yap, MD, PhD; David S. Hong, MD; Olivier Rixe, MD, PhD; Ursa Brown-Glaberman, MD; Andreea Varga, MD; Christophe Massard, MD; Capucine Baldini, MD; Sergey Efuni, MD, PhD; Barbara Kapelan, BS; Yi Liu, PhD; Eniola Ogunmefun, MD; Tomonori Tayama, MS; Henry Zhao, PhD; Denis J. Healy, MBA; Robert Latek, PhD; Daisuke Nakashima, MS; Emrullah Yilmaz, MD, PhD Completed Clinical Trials Antibody; Biomarkers; Clinical study; Clinical trial; Regulatory T cell (Treg cell); Solid tumors
288 Poster Presentation A Phase 1 Study of IMC-001, a PD-L1 Blocker, in Patients with Metastatic or Locally Advanced Solid Tumors Bhumsuk Keam, MD, PhD; Tae Min Kim, MD, PhD; Do-Youn Oh, MD, PhD; Chan-Young Ock, MD, PhD; Won Ki Kang, MD, PhD; Yeon Hee Park, MD, PhD; Jeeyun Lee, MD, PhD; Ji Hye Lee, MD; Yun Jeong Song, MD; Young Suk Park, MD, PhD; Completed Clinical Trials Antibody; Checkpoint blockade; Clinical study; Clinical trial; Solid tumors; T cell
289 Poster Presentation PGV-001: A Phase 1 Trial of a Personalized Neoantigen Peptide Vaccine for the Treatment of Malignancies in the Adjuvant Setting. Thomas U. Marron, MD, PhD; Julia Kodysh, PhD; Alex Rubinsteyn, PhD; John Finnigan, MD PhD; Ana Blazquez, PhD; Mansi Saxena, PhD; Marcia Meseck; Timothy O’Donnell; Daniela Delbeau, RN; Matthew Galsky, MD; Deborah , Doroshow, MD PhD; Brett Miles, MD; Krysztof Misiukiewicz, MD; Hanna Irie, MD PhD; Amy Tiersten, MD; Samir Parekh, MD; Marshall Posner, MD; Andrea Wolf, MD MPH; John Mandeli, PhD; Jeffrey Hammerbacher, PhD; Michael Donovan, MD PhD; Rachel Brody, MD PhD; Sacha Gnjatic, PhD; Eric Schadt, PhD; Philip Friedlander, MD PhD; Nina Bhardwaj, MD PhD; Completed Clinical Trials Clinical trial; Immune monitoring; Neoantigens; Solid tumors; Vaccine
290 Poster Presentation Cytokine and immune subset signatures in patients with various solid and hematological malignancies treated with oncolytic vaccinia virus delivered by autologous stromal vascular fraction cells Dobrin Draganov, PhD; Antonio F. Santidrian; Ivelina Minev, MSc; Duong H. Nguyen, PhD; Dmitriy Zamarin, MD, PhD; Francesco M. Marincola, MD; Boris Minev, MD; Completed Clinical Trials Adoptive immunotherapy; Antigen presenting cells; Clinical study; Immune monitoring; NK/NK T cell; Regulatory T cell (Treg cell); Solid tumors; Stem cell/cancer-initiating cell; T cell; T cell lineages
291 Poster Presentation Phase Ib Study of Selicrelumab (CD40 agonist) in Combination with Atezolizumab (anti-PD-L1) in Patients with Advanced Solid Tumors Fabrice Barlesi, Prof, MD, PhD; Martijn Lolkema, MD, PhD; Kristoffer Staal Rohrberg, MD, PhD; Cinta Hierro, MD; Aurelien Marabelle, MD, PhD; Albiruni Abdul Razak, MD; Luis Teixeira, MD, PhD; Valentina Boni, MD, PhD; Wilson H. Miller, Jr, MD, PhD; Charu Aggarwal, MD, MPH; Martin Stern, MD; Olivera Cirovic, MD, PhD; Olivera Cirovic, MD, PhD; Barbara Romagnoli, PhD; Randolph Christen, MD; Raksha Dodia, PhD; Kevin Smart, PhD; Bernhard Reis, PhD; Nicolas Staedler, PhD; Carl Watson; Neeltje Steeghs, MD, PhD; Completed Clinical Trials Antigen presenting cells; Checkpoint blockade; Clinical study; Solid tumors
292 Poster Presentation Immune checkpoint inhibitor induced overlapping cardiac and neuromuscular toxicities: Highlight of early diagnosis, early initiation of immunosuppressive therapy and multidisciplinary management HoWai D. Siu, MBBS, MMed; Robert S. O'Neill, MedSci MBBS; Matthew H. Tong, MD; JunHee Hong, Bmed, MD; Carole A. Harris, MBBS (Hons) MMed BPharm FRACP; Morteza Aghmesheh, MD, GradDipSC, PhD, FRACP; Hussein S. Hussein, Dr; Completed Clinical Trials Checkpoint blockade; Immune suppression; Immune toxicity; Inflammation
293 Poster Presentation Results of the first-in-human clinical trial with personalized multi-target adoptive cell therapy (ACTolog IMA101) Apostolia M. Tsimberidou, MD, PhD; Apostolia M. Tsimberidou, MD, PhD; Apostolia M. Tsimberidou, MD, PhD; Kerstin Guenther; Amir Alpert; Borje Andersson, MD, PhD; Zoe Coughlin; Jens Fritsche, PhD; Norbert Hilf; Patrick M. Hwu, MD; Mamta Kalra, PhD; Sabrina Kuttruff-Coqui, PhD; Dominik Maurer, PhD; Regina Mendrzyk; Ali Mohamed; Becky Norris; Anna Nowak; Rita Ort; Carsten Reinhardt, MD, PhD; Fabian Richter; Arun Satelli; Oliver Schoor, PhD; Kerry A. Sieger; Harpreet Singh, PhD; David Vining, MD; Claudia Wagner; Toni Weinschenk, PhD; Cassian Yee, MD; Steffen Walter, PhD; Completed Clinical Trials Adoptive immunotherapy; Biomarkers; Checkpoint blockade; Clinical trial; Immune monitoring; Solid tumors; T cell; Targeted therapy; Tumor antigens
294 Oral Presentation CD8 PET imaging of tumor infiltrating T cells in advanced solid tumors: a phase I first-in-human study of 89Zr-IAB22M2C, a radiolabeled anti-CD8 minibody Michael D. Farwell, MD; Raymond F. Gamache, PhD; Neeta Pandit-Taskar, MD; Mike Postow, MD; Michael S. Gordon; Ian A. Wilson, PhD; Alessandro Mascioni, PhD; Anna M. Wu, PhD; William Le; Avital Weiss; Ronald Korn, MD PhD; Completed Clinical Trials Biomarkers; Clinical study; Clinical trial; Solid tumors; T cell; Tumor infiltrating lymphocytes (TILs); Tumor microenvironment
295 Poster Presentation First-in-human Phase I trial of IBI188, an anti-CD47 targeting monoclonal antibody, in patients with advanced solid tumors and lymphomas Nehal Lakhani, MD, PhD; Marlana Orloff, MD; Siqing Fu, MD, PhD; Ying Liu; Yan Wang; Hui Zhou; Kedan Lin, PhD; Fang Liu; Shuling Yan; Amita Patnaik, MD FRCP(C) Completed Clinical Trials Autoimmunity; Clinical trial; Immune toxicity
296 Poster Presentation Immune correlates of clinical response to Avelumab in patients with advanced thymic epithelial tumors Yo-Ting Tsai, PhD; Arun Rajan, MD; James L. Gulley, MD, PhD; Jeffrey Schlom, PhD; Renee N. Donahue, PhD; Completed Clinical Trials Autoimmunity; B cell; Biomarkers; Checkpoint blockade; Immune monitoring; Solid tumors
297 Poster Presentation Modeling the efficacy of NY-ESO-1 TCR T cells (letetresgene autoleucel; GSK3377794) in patients with synovial sarcoma: correlations of response with transduced cell kinetics and biomarkers Alexandra Gyurdieva; Stefan Zajic; Ya-Fang Chang; E. Andres Houseman; Shan Zhong; Jaegil Kim; David C. Turner; Laura A. Johnson; Ioanna S. Eleftheriadou; Jenna Tress; Aisha N. Hasan, MBBS MD; Victoria L. Chiou; Naimish Pandya; John Glod, MD; Dejka Araujo, MD; Warren Chow; Mihaela Druta; George D. Demetri; Brian A. Van Tine, MD, PhD; Sandra P. D’Angelo; Completed Clinical Trials Adoptive immunotherapy; Biomarkers; Chemokine; Cytokine; Gene expression; Immune monitoring; Pediatric tumors; Solid tumors; T cell; Targeted therapy
298 Poster Presentation Final analysis of the Phase 1 trial of NY-ESO-1–specific T-cell receptor (TCR) T-cell therapy (letetresgene autoleucel; GSK3377794) in patients with advanced synovial sarcoma (SS) Sandra P. D'Angelo, MD; George D. Demetri; Brian A. Van Tine, MD, PhD; Mihaela Druta; John Glod, MD; Warren Chow; Naimish Pandya; Aisha N. Hasan, MBBS MD; Victoria L. Chiou; Jenna Tress; Julie Edwards; Tim Young; Mary Woessner; Alexandra Gyuerdieva; Stefan Zajic; Sophia Goodison; Dejka Araujo, MD; Completed Clinical Trials Adoptive immunotherapy; Clinical trial; Solid tumors; T cell; Tumor antigens
299 Poster Presentation Immuno-Metabolic Signatures of Dendritic Cells Associate With T-cell Responses in Melanoma Patients Juraj Adamik, PhD; Deena M. Maurer, MS; Paul Munson, PhD; Alexis J. Combes, PhD; Philippe Pierre, PhD; Matthew F. Krummel, PhD; Rafael J. Argüello, PhD; Lisa H. Butterfield, PhD; Completed Clinical Trials Antigen presenting cells; Dendritic cell; Gene expression; Metabolism; Vaccine
300 Poster Presentation Final analysis of a prospective, randomized, double-blind, placebo-controlled phase IIb trial of tumor lysate, particle-loaded, dendritic cell vaccine in stage III/IV melanoma: 36-month analysis Lexy M. Adams, MD, MPH; Robert C. Chick, M.D.; Guy T. Clifton, MD; Timothy J. Vreeland, BS MD; Patrick M. McCarthy, MD; Anne E. O'Shea, MD; Phil M. Kemp Bohan, MD; Annelies T. Hickeron, MD; John W. Myers, MD; Jessica L. Cindass, MD; Diane F. Hale, MD; Mark B. Faries, MD; John Hyngstrom, MD; Adam C. Berger, FACS, MD; James W. Jakub, MD; Jeffrey J. Sussman, MD; Montaser F. Shaheen, MD; Thomas E. Wagner, BS, MD; George E. Peoples, MD, FACS; Completed Clinical Trials Clinical trial; Dendritic cell; Solid tumors; Tumor antigens; Vaccine
301 Poster Presentation Association of response with survival outcomes with atezolizumab in combination with vemurafenib and cobimetinib in the phase 3 IMspire150 study Paolo A. Ascierto, MD; Karl D. Lewis, MD; Caroline Robert, MD, PhD; Daniil Stroyakovskiy, MD, PhD; Helen Gogas, MD, PhD; Svetlana Protsenko, MD, DSc; Rodrigo P. Pereira, MD; Thomas Eigentler, MD; Piotr Rutkowski, MD; Lev Demidov, MD, DSc; Georgy Moiseevich Manikhas, MD, PhD; Haocheng Li, PhD; Qian Zhu, PhD; Edward McKenna, PharmD, BCOP; Virginia McNally, PhD; Ralf Gutzmer, MD; Grant A. McArthur, MBBS (Hons), PhD, FRACP, FAHMS; Completed Clinical Trials Checkpoint blockade; Clinical study; Solid tumors; Targeted therapy
302 Poster Presentation A phase I trial of intratumoral PVSRIPO in patients with unresectable treatment refractory melanoma Georgia M. Beasley, MD, MHs; Nellie E. Farrow, MD; Karenia Landa, MD; Maria Angelica Selim, MD; Sin-Ho Jung, PhD; Darell D. Bigner, MD, PhD; Andrea True Kelly, PhD; Smita Nair, PhD; Matthias Gromeier, MD; April Salama, MD; Completed Clinical Trials Clinical trial; Solid tumors; Vaccine
303 Oral Presentation Phase II Trial of Neoadjuvant Nivolumab (Nivo) and Intra-Tumoral (IT) CMP-001 in High-Risk Resectable Melanoma (Neo-C-Nivo): Final Results. Diwakar Davar, MD; Arivarasan Karunamurthy; Douglas Hartman; Richelle DeBlasio, B.Sc.; Joe-Marc JM. Chauvin, PhD; Quanquan Ding; Ornella Pagliano; Amy Rose, RN; John M. Kirkwood, MD; Hassane M. Zarour, MD; Completed Clinical Trials Checkpoint blockade; Clinical trial; Immune contexture; TLR
304 Poster Presentation Intratumoral injection of CMP-001, a Toll-like receptor 9 (TLR9) agonist, in combination with pembrolizumab reversed programmed death receptor 1 (PD-1) blockade resistance in advanced melanoma Mohammed M. Milhem, MBBS; Yousef Zakharia, MD; Diwakar Davar, MD; Elizabeth I. Buchbinder, MD; Theresa Medina, MD; Adil Daud, MD; Antoni Ribas, MD, PhD; Jiaxin Niu, MD, PhD; Geoffrey T. Gibney, MD; Kim A. Margolin, MD; Anthony J. Olszanski, MD, RPh; Inderjit Mehmi, MD; Takami Sato, MD; Montaser Shaheen, MD; Aaron J. Morris, PhD; David Mauro, MD, PhD; Katie Campbell, PhD; Heather Kelley, MA; Riyue Bao, PhD; George J. Weiner, MD; Jason J. Luke, MD; Arthur M. Krieg, MD; James E. Wooldridge, MD; John M. Kirkwood, MD; Completed Clinical Trials Checkpoint blockade; Clinical study; Dendritic cell; T cell; TLR; Tumor microenvironment
305 Poster Presentation Technical considerations for normalizing digital spatial profiling data with multiple within-patient samples Tyler D. Hether; Tim Howes, PhD; Christine N. Spencer, PhD; Travis Hollman, PhD, MD; Jason W. Reeves; Danny Wells, BA, PhD; Claire F. Friedman, MD; Theresa LaVallee; Jedd D. Wolchok, MD, PhD; Sarah E. Warren, PhD; Completed Clinical Trials Antibody; Bioinformatics; Biomarkers; Clinical trial; Gene expression; RNA; Solid tumors; Tumor microenvironment; Tumor stroma
306 Poster Presentation Predictors of immunotherapy benefit in Merkel cell carcinoma Alec J. Kacew, BA; Harita Dharaneeswaran; Gabriel J. Starrett; Manisha Thakuria; Nicole R. LeBoeuf, MD, MPH; Ann W. Silk, MD, MS; James A. DeCaprio; Glenn J. Hanna, MD; Completed Clinical Trials Biomarkers; Checkpoint blockade; Clinical study; Clinical trial; Solid tumors
307 Poster Presentation Atezolizumab plus vemurafenib and cobimetinib provides favorable survival outcomes in patients with high tumor mutation burden and proinflammatory gene signature in the phase 3 IMspire150 study Karl D. Lewis, MD; Paolo A. Ascierto, MD; Caroline Robert, MD, PhD; Rodrigo Munhoz, MD; Gabriella Liszkay, MD; Luis De La Cruz Marino, MD; Judit Olah, MD; Paola Queirolo, MD; Jacek Mackiewicz, MD, PhD; Kalpit Shah, PhD; Harper Forbes, MSc; Christian Hertig, PhD; Yibing Yan, PhD; Ralf Gutzmer, MD; Grant A. McArthur, MBBS (Hons), PhD, FRACP, FAHMS; Completed Clinical Trials Checkpoint blockade; Clinical study
308 Poster Presentation Indirect treatment comparison of nivolumab versus placebo as adjuvant treatment for melanoma Jeffrey S. Weber, MD, PhD; Paolo A. Ascierto, MD; Mark R. Middleton, MD, PhD; Delphine Hennicken; Roberto Zoffoli; Anne Pieters; Adenike Amadi; Katrin Kupas; Srividya Kotapati; Andriy Moshyk, MSc, MD; Dirk Schadendorf, MD; Completed Clinical Trials Checkpoint blockade; Immune adjuvant; Solid tumors
309 Poster Presentation The role of tumor-draining lymph nodes in the tuning of systemic T cell immunity by CTLA-4 blockade is revealed by local delivery of tremelimumab in early-stage melanoma: data from a Phase-I trial Jessica C. Notohardjo, MD; Kim M. van Pul, MD; Anita G. Stam; Dafni Chondronasiou; Sinead Lougheed; Petrousjka M. van den Tol; Karin Jooss, PhD; Ronald J. Vuylsteke, MD, PhD; Alfons J. van den Eertwegh; Tanja D. de Gruijl, PhD; Completed Clinical Trials Checkpoint blockade; Clinical study; Dendritic cell; Immune adjuvant; Immune monitoring; MDSC; T cell; TLR; Tumor microenvironment
310 Poster Presentation The effect of pretreatment with G-CSF prior to dendritic cell collection during the phase IIb trial of an autologous DC-based vaccine for advanced, resectable melanoma Anne E. O'Shea, MD; Robert C. Chick, M.D.; Guy T. Clifton, MD; Timothy J. Vreeland, BS MD; Lexy M. Adams, MD, MPH; Patrick M. McCarthy, MD; Phillip M. Kemp Bohan, MD; Annelies T. Hickeron, MD; John W. Myers, MD; Jessica L. Cindass, MD; Tommy A. Brown, MD; Diane F. Hale, MD; Mark B. Faries, MD; John Hyngstrom, MD; Adam C. Berger, FACS, MD; James W. Jakub, MD; Jeffrey J. Sussman, MD; Montaser F. Shaheen, MD; Thomas E. Wagner, BS, MD; George E. Peoples, MD, FACS; Completed Clinical Trials Antigen presenting cells; Clinical trial; Dendritic cell; Solid tumors; Tumor antigens; Vaccine
311 Poster Presentation Phase II Trial of Lymphodepletion Plus Adoptive Cell Transfer with or Without Dendritic Cell Vaccination in Patients with Metastatic Melanoma Chantal Saberian, MD; Rodabe N. Amaria, MD; Cara Haymaker, PhD; Marie Andree Forget, PhD; Roland L. Bassett, BS; Isabella C. Glitza, MD, PhD; Gregory A. Lizee, PhD; Cassian Yee, MD; Jeniffer L. McQuade, MD; Michael K. Wong, MD PhD FRCPC; Hussein A. Tawbi, MD, PhD; Sapna Patel, MD; Adi Diab, MD; Michael A. Davies, MD, PhD; Patrick M. Hwu, MD; Chantale Bernatchez, PhD; Completed Clinical Trials Antigen presenting cells; Clinical study; Clinical trial; Dendritic cell; T cell; Tumor infiltrating lymphocytes (TILs); Tumor antigens; Vaccine
312 Poster Presentation Female sex independently predicts adjuvant immunotherapeutic benefit from CTLA4 immune checkpoint inhibition Ahmad A. Tarhini, MD, PhD, MS; Ni Kang; Sandra Lee; F. Stephen Hodi, Jr., MD; Gary I. Cohen; Omid Hamid, MD; Laura F. Hutchins; Jeffrey A. Sosman, MD; Harriett M. Kluger; Zeynep Eroglu, MD; Henry Koon, MD; Donald P. Lawrence, MD; Kari L. Kendra; David R. Minor, MD; Carrie Lee, RN, MSN, OCN; Mark R. Albertini, MD; Lawrence E. Flaherty, MD; Teresa Petrella; Howard Striecher; Vernon K. Sondak, MD; John M. Kirkwood, MD; Completed Clinical Trials Biomarkers; Checkpoint blockade; Clinical trial; Immune tolerance; Solid tumors
788 Oral Presentation Pembrolizumab for Patients with Leptomeningeal Metastasis from Solid Tumors: Efficacy, Safety and Cerebrospinal Fluid Biomarkers Jarushka Naidoo, MB BCH MHS; Karisa C. Schreck; Wei Fu; Chen Hu; Roisin M. Connolly, MD; Cesar A. Santa-Maria, MD, MSCI; Evan J. Lipson, MD; Matthias Holdhoff; Patrick Forde, MD; Joanne Riemer, RN BSN; Amanda Barnes; Nafi Aygun; Lawrence Kleinberg; Kristin Redmond; Christopher Douville; Chetan Bettegowda; Arun Venkatesan; Stuart Grossman; Julie R. Brahmer, MD, MS; Completed Clinical Trials Biomarkers; Checkpoint blockade; Clinical study; Clinical trial; Cytokine
789 Poster Presentation Intratumoral plasmid IL-12 expands CD8+ T cells and induces a clinically validated CXCR3 signature in triple-negative breast cancer Erika J. Crosby, Ph.D.; Hiroshi Nagata; Melinda Telli; Chaitanya R. Acharya; Irene Wapnir; Kaitlin Zablotsky; Erica Browning, BS; Reneta Hermiz; Lauren Svenson; Donna Bannavong; Kellie Malloy; David A. Canton, PhD; Christopher G. Twitty, PhD; Takuya Osada; Herbert K. Lyerly, MD; Completed Clinical Trials Biomarkers; Checkpoint blockade; Chemokine; Clinical study; Immune tolerance; MDSC; T cell; Tumor microenvironment
790 Poster Presentation A Phase II study (TACTI-002) of eftilagimod alpha (a soluble LAG-3 protein) with pembrolizumab in PD-L1 unselected patients with metastatic non-small cell lung(NSCLC) or head and neck carcinoma(HNSCC) Matthew G. Krebs, MD, PhD; Margarita Majem; Enriqueta Felip, MD PhD; Martin Forster; Bernard Doger; Tim Clay; Enric Carcereny, MD; Julio A. Peguero, MD; Leora Horn; Pawan Bajaj; Patricia Roxburgh; Chrystelle Brignone; Christian Mueller, MSc; Frederic Triebel; Completed Clinical Trials Antigen presenting cells; Checkpoint blockade; Clinical study; Clinical trial; Dendritic cell
791 Poster Presentation A Phase II Study of the Anti-Programmed Cell Death-1 (PD-1) Antibody Penpulimab in Patients with Relapsed or Refractory Classic Hodgkin Lymphoma (cHL) Yuqin Song, MD; Keshu Zhou, MD; Chuan Jin, MD; Zhengzi Qian, MD; Ming Hou, MD; Lei Fan, MD; Fei Li, MD; Kaiyang Ding, MD; Hui Zhou, MD; Xiaoling Li, MD; Bing Chen, MD; Xiuhua Sun, MD; Xianmin Song, MD; Ming Jiang, MD; Qingyuan Zhang, MD; Lihong Liu, MD; Guohua Yu, MD; Yu Hu, MD; Zheng Zhao, MD; Ligen Liu, MD; Hongwei Xue, MD; Jun Luo, MD; Bai He, MD; Xiaoping Jin, PhD; Maxwell Wang, PhD; Baiyong Li, PhD; Yu Xia, PhD; Jun Zhu, MD; Completed Clinical Trials Checkpoint blockade; Clinical study; Clinical trial
793 Poster Presentation TG4001 (Tipapkinogene sovacivec) and avelumab for recurrent/metastatic (R/M) Human Papilloma Virus (HPV)-16+ cancers: clinical efficacy and immunogenicity Christophe Le Tourneau, MD, PhD; Philippe Cassier, MD; Frederic Rolland; Sébastien Salas; Jean Marc Limacher, MD, MSc; Olivier Capitain; Olivier Lantz; Ana Lalanne; Christina Ekwegbara; Annette Tavernaro; Hakim Makhloufi; Kaidre Bendjama; Jean-Pierre Delord, MD; Completed Clinical Trials Antibody; Checkpoint blockade; Clinical trial; Immune contexture; Solid tumors; T cell; Targeted therapy; Tumor antigens; Tumor microenvironment; Vaccine
794 Poster Presentation Safety and efficacy results from a phase 1/1b study of intratumoral MK-4621, a retinoic acid-inducible gene I (RIG-I) agonist, plus intravenous pembrolizumab in patients with advanced solid tumors Victor Moreno, PhD, MD; Caroline Gaudy-Marqueste; Martin Wermke, MD; Antoine Italiano, MD; Emanuela Romano, MD, PhD; Aurelien Marabelle, MD, PhD; Emilee Connors, PhD; Heng Zhou; Konstantin Dobrenkov, MD; Elliot Chartash, MD; Emiliano Calvo, MD PhD; Completed Clinical Trials Checkpoint blockade; Clinical trial; Solid tumors
795 Oral Presentation A multicenter phase II trial (SWOG S1609, Cohort 51) of Ipilimumab and Nivolumab in metastatic or unresectable angiosarcoma: a substudy of dual anti-CTLA-4 and anti-PD-1 blockade in rare tumors (DART) Michael J. Wagner, M.D.; Megan Othus; Sandip P. Patel, M.D.; Christopher W. Ryan; Ashish Sangal; Benjamin Powers; George T. Budd; Adrienne I. Victor; Chung-Tsen Hsueh; Rashmi Chugh; Suresh Nair; Kirsten M. Leu; Mark Agulnik, MD; Elad Sharon, MD, MPH; Edward Mayerson; Melissa Plets, M.S.; Charles D. Blanke; Howard Streicher, MD; Young Kwang Chae, MD, MPH, MBA; Razelle Kurzrock; Completed Clinical Trials Checkpoint blockade; Clinical study; Clinical trial; Coinhibition; Solid tumors
796 Poster Presentation A phase I/II trial combining Avelumab and Trabectedin for advanced liposarcoma and leiomyosarcoma Michael J. Wagner, M.D.; Qianchuan He; Yuzheng Zhang; Lee Cranmer; Elizabeth T. Loggers; Sabrina McDonnell; Shannon Maxwell; Seth M. Pollack, MD; Completed Clinical Trials Checkpoint blockade; Chemotherapy; Clinical study; Clinical trial; Monocyte/Macrophage; T cell
797 Poster Presentation Significant anti-tumor activity of HBI-8000, a class I histone deacetylase inhibitor (HDACi) in combination with nivolumab (NIVO) in anti-PD1 therapy-naïve advanced melanoma (TN-Mel) Nikhil I. Khushalani, MD; Andrew S. Brohl, MD; Joseph Markowitz, MD, PhD; Lyudmila Bazhenova, MD; Gregory A. Daniels, MD, PhD; Heather Yeckes-Rodin, MD; Siqing Fu, MD, PhD; Lori M. McCormick, RN; Michael Kurman, MD; Mireille Gillings, PhD, Hon DSc; Gloria Lee, MD, PhD; Zeynep Eroglu, MD; Completed Clinical Trials Epigenetics; Checkpoint blockade; Clinical study; Clinical trial