Abstracts

Poster Presentation Dates

All odd numbered posters will be presented on Friday, November 8, 2019, while even numbered posters will be presented on Saturday, November 9, 2019.

Posters will be on display from 7 a.m. - 8 p.m., with the presenting authors required to be at their posters during lunch (12:30 - 2 p.m. on Friday, Nov. 8, and 12:35 - 2:05 p.m. on Saturday, Nov. 9) and also during the poster reception (6:30 - 8p.m. on Friday, Nov. 8, and 7 - 8:30 p.m. on Saturday, Nov. 9).

#	Title	Authors	Category	Keywords
O74	Fibroblast activation protein is expressed by human and murine leukocytes and nonspecific inhibition of FAP enhances anti-PD-1 therapy in murine models of PDAC	Louis M. Weiner, MD; Allison Fitzgerald, MD/PhD Candidate; Shangzi Wang, PhD;	Tumor and Stromal Cell Biology	Checkpoint blockade; NK/NK T cell; Solid tumors; Tumor microenvironment; Tumor stroma
O75	Selective induction of S100a8/a9 heterodimer protein in pancreatic cancer in response to immune selection pressure	Louis M. Weiner, MD; Reham Ajina, MS	Tumor and Stromal Cell Biology	Immune suppression; Inflammation; Proteomics; Solid tumors; Tumor infiltrating lymphocytes (TILs); Tumor evasion; Tumor microenvironment; Tumor stroma
O76	Interferon-Gamma Mediated T Cell Exhaustion Generates Distinct Tumor Microenvironments in Synchronous Melanoma via PD-1/PD-L1 Axis	Peter A. Prieto, MD, MPH; Shuyang S. Qin, BS; Alyssa Williams; Booyeon Han, BS; Rachel Jewell; Katherine M. Jackson, MD; Alexander C. Chacon, MD; Edward Englerth III, BS; Brian A. Belt, JD; Goran Micevic, MD, PhD; David C. Linehan, MD; Scott Gerber, PhD; Alexandre Reuben;	Tumor and Stromal Cell Biology	Chemokine; Costimulation; Immune suppression; Immune tolerance; T cell; Tumor evasion; Tumor microenvironment; Tumor stroma
O77	Clinicopathological and genomic correlates of PD-L1 expression in nonsquamous non-small cell lung cancer.	Giuseppe Lamberti, MD; Liam Spurr; Yvonne Li; Biagio Ricciuti, MD; Gonzalo Recondo, MD; Renato Umeton; Andrew Cherniak; Matthew L. Meyerson, MD, PhD; Mark Awad, MD PhD;	Tumor and Stromal Cell Biology	Bioinformatics; Biomarkers; Checkpoint blockade; Solid tumors
O78	Identification of breast cancer neoantigens exposed by radiation therapy	Claire Lhuillier, PhD; Nils Rudqvist; Takahiro Yamazaki, PhD; Lorenzo Galluzzi; Sandra Demaria, MD;	Tumor and Stromal Cell Biology	Neoantigens; Radiotherapy; Solid tumors; Tumor antigens; Vaccine
O79	Mapping the spatial architecture of acute myeloid leukemia in the bone marrow microenvironment by multiplexed ion beam imaging	Xavier Rovira-Clave, PhD; Sizun Jiang, PhD; Xavier Rovira-Clave, PhD; Yunhao Bai, BS; Bokai Zhu; Marc Bosse, PhD; Michael Angelo, MD, PhD; Yara Banz, MD, PhD; Christian M. Schürch, MD, PhD; Garry P. Nolan, PhD;	Tumor and Stromal Cell Biology	B cell; Checkpoint blockade; Immune monitoring; Leukemia/Lymphoma; Myeloid cells; Proteomics; T cell; Tumor evasion; Tumor microenvironment; Tumor stroma
O80	Atlas of clinically-distinct cell states and cellular ecosystems across human solid tumors	Bogdan Luca; Ash Alizadeh; Max Diehn; Aaron Newman; Andrew Gentles, PhD; Chloé Steen; Andrew Gentles, PhD;	Tumor and Stromal Cell Biology	Bioinformatics; Biomarkers; Gene expression; Immune contexture; Systems biology; Tumor infiltrating lymphocytes (TILs); Tumor microenvironment; Tumor stroma
P834	The actin regulatory protein hMENA is a key player in the paracrine TGF-β mediated crosstalk between tumor cells and cancer associated fibroblasts	Paola Nistico', MD; Roberta Melchionna; Paola Trono; Francesca Di Modugno, PhD; Anna Di Carlo; Sheila Spada, PhD; Giuliana Falasca; Isabella Sperduti; Barbara Antoniani; Daniel D'Andrea; Paolo Visca; Gian Luca Grazi; Francesco Facciolo; Aldo Scarpa; Paola Nistico', MD;	Tumor and Stromal Cell Biology	Solid tumors; Tumor microenvironment; Tumor stroma
P835	The role of sialylation in stromal cell mediated immunosuppression in the colorectal tumour microenvironment	Aideen E. Ryan, PhD; Hannah Egan, BSC; Kevin Lynch, PhD; Niamh Leonard, MSc; Michael O; Laurence J. Egan, MD; Thomas Ritter; Oliver Treacy, PhD; Aideen E. Ryan, PhD;	Tumor and Stromal Cell Biology	Immune suppression; Inflammation; Monocyte/Macrophage; Solid tumors; T cell; Tumor stroma
P836	Immunopathological properties of the fibroblastic niche for cancer stem cells and the niche-targeted immunotherapy	Toshihiko Torigoe, MD, PhD; Yoshihiko Hirohashi, MD, PhD; Toshihiko Torigoe, MD, PhD;	Tumor and Stromal Cell Biology	Stem cell/cancer-initiating cell; Solid tumors; Tumor antigens; Tumor microenvironment; Tumor stroma
P837	Roles of nitric oxide synthase and cyclooxygenase inhibition in potentiating immune response in murine models of 4T1 mammary tumor	Veena Somasundaram, PhD; Anne C. Gilmore; Debashree Basudhar; Erika Palmieri; David A. Scheiblin; William F. Heinz; Robert Cheng; Lisa Ridnour, PhD; Stephen J. Lockett; Daniel W. McVicar, PhD; David A. Wink;	Tumor and Stromal Cell Biology	Biomarkers; Inflammation; Myeloid cells; Tumor microenvironment
P838	Disrupting hypoxic tumor niches to sensitize pancreatic cancer to immunotherapy	Arthur J. Liu, BS; Michael A. Curran, PhD;	Tumor and Stromal Cell Biology	Angiogenesis; Immune suppression; Solid tumors; Tumor infiltrating lymphocytes (TILs); Tumor microenvironment
P839	DNA demethylating agent sensitizes lung cancer cells to immune attack of γδ T cells	Rueyhung R. Weng, PhD; Chien-Ting Lin; Hsuan-Hsuan Lu; Chong-Jen Yu; Hsing-Chen Tsai;	Tumor and Stromal Cell Biology	Chemotherapy; Proteomics; Solid tumors; T cell; Tumor antigens
P840	Characterization of syngeneic tumor models and their microenvironment for immunotherapeutic approaches	Marco Carretta, PhD; Marie Louise Thorseth; Dennis A. Agardy; Silvia Redondo Garcia; Anne Mette Hvid Larsen, M.Sc; Dorota E. Kuczek, MSc; Daniel H. Madsen;	Tumor and Stromal Cell Biology	Solid tumors; Tumor microenvironment
P841	NCG/CRL as a novel (Charles River) humanized mouse model for pre-clinical oncology studies: immunophenotypic characterization and performance monitoring	Jenny Rowe, PhD; Christoph CE. Eberle, PhD; Jenny Rowe, PhD; Robert Mihalek, PhD; Stephen Festin;	Tumor and Stromal Cell Biology	Checkpoint blockade; Immune monitoring; Leukemia/Lymphoma; Myeloid cells; NK/NK T cell; Solid tumors; T cell; T cell lineages; Tumor infiltrating lymphocytes (TILs); Tumor microenvironment
P843	Oral cancers expressing Glycoprotein-A repetitions predominant (GARP) show poor prognosis	Rieneke van de Ven, PhD; Jan Kloosterman, Bsc; Irene H. Nauta, M.Sc; Sonja H. Ganzevles, BSc; Elisabeth Bloemena, Prof. Dr.; C. René Leemans, MD, PhD; Ruud H. Brakenhoff, MD, PhD;	Tumor and Stromal Cell Biology	Biomarkers; Immune suppression; Immune tolerance; Solid tumors; Tumor evasion; Tumor microenvironment
P844	Investigating the immunologic landscape and tumor-specific target identification in human clear cell renal carcinoma	Nivedita Chowdhury, MS; Aleksandar Obradovic; David H. Aggen, MD, PhD; Michael Johnson; Charles G. Drake, MD, PhD;	Tumor and Stromal Cell Biology	Neoantigens; Solid tumors; T cell; Tumor infiltrating lymphocytes (TILs); Tumor antigens; Tumor microenvironment
P845	Targeting of Lactate Dehydrogenase C and its effects on the tumor immune microenvironment: two birds with one stone	Adviti Naik, PhD; Julie Decock, PhD; Aljazi M. Al-Khalifa;	Tumor and Stromal Cell Biology	Carcinogenesis; Cytokine; Gene expression; Immune contexture; Immune suppression; Metabolism; Solid tumors; Tumor antigens; Tumor evasion; Tumor microenvironment
P846	Tumor-infiltrating B cells control the progression of oropharyngeal squamous cell carcinoma via cell-to-cell interactions with CD8+ T cells	Kamila Hladíková; Vladimír Koucký; Jan Boucek; Jan Laco; Marek Grega; Aleš Ryška; Radek Špíšek; Anna Fialová;	Tumor and Stromal Cell Biology	B cell; Carcinogenesis; Checkpoint blockade; Costimulation; T cell; Tumor infiltrating lymphocytes (TILs); Tumor microenvironment
P847	Macrophages-induced H19 Up-regulation Activate the miR-193b/MAPK1 Axis and Promotes Cell Aggressiveness in Hepatocellular Carcinoma	Yingnan Ye; Jinpu Yu; Yingnan Ye;	Tumor and Stromal Cell Biology	Biomarkers; Monocyte/Macrophage; Tumor microenvironment
P848	MiR-17 Cluster Promoted M2-polarized Tumor Associated Macrophages Related Cell Aggressiveness via Inducing the Imbalance of TGF-β1 /BMP7 Pathways in Hepatocellular Carcinoma	Yingnan Ye; Junya Ning; Jinpu Yu;	Tumor and Stromal Cell Biology	Monocyte/Macrophage; Tumor microenvironment