Abstracts

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Poster Presentation Dates

All odd numbered posters will be presented on Friday, November 8, 2019, while even numbered posters will be presented on Saturday, November 9, 2019.

Posters will be on display from 7 a.m. - 8 p.m., with the presenting authors required to be at their posters during lunch (12:30 - 2 p.m. on Friday, Nov. 8, and 12:35 - 2:05 p.m. on Saturday, Nov. 9) and also during the poster reception (6:30 - 8p.m. on Friday, Nov. 8, and 7 - 8:30 p.m. on Saturday, Nov. 9).


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# Title Authors Category Keywords
O74 Fibroblast activation protein is expressed by human and murine leukocytes and nonspecific inhibition of FAP enhances anti-PD-1 therapy in murine models of PDAC Louis M. Weiner, MD; Allison Fitzgerald, MD/PhD Candidate; Shangzi Wang, PhD; Tumor and Stromal Cell Biology Checkpoint blockade; NK/NK T cell; Solid tumors; Tumor microenvironment; Tumor stroma
O75 Selective induction of S100a8/a9 heterodimer protein in pancreatic cancer in response to immune selection pressure Louis M. Weiner, MD; Reham Ajina, MS Tumor and Stromal Cell Biology Immune suppression; Inflammation; Proteomics; Solid tumors; Tumor infiltrating lymphocytes (TILs); Tumor evasion; Tumor microenvironment; Tumor stroma
O76 Interferon-Gamma Mediated T Cell Exhaustion Generates Distinct Tumor Microenvironments in Synchronous Melanoma via PD-1/PD-L1 Axis Peter A. Prieto, MD, MPH; Shuyang S. Qin, BS; Alyssa Williams; Booyeon Han, BS; Rachel Jewell; Katherine M. Jackson, MD; Alexander C. Chacon, MD; Edward Englerth III, BS; Brian A. Belt, JD; Goran Micevic, MD, PhD; David C. Linehan, MD; Scott Gerber, PhD; Alexandre Reuben; Tumor and Stromal Cell Biology Chemokine; Costimulation; Immune suppression; Immune tolerance; T cell; Tumor evasion; Tumor microenvironment; Tumor stroma
O77 Clinicopathological and genomic correlates of PD-L1 expression in nonsquamous non-small cell lung cancer. Giuseppe Lamberti, MD; Liam Spurr; Yvonne Li; Biagio Ricciuti, MD; Gonzalo Recondo, MD; Renato Umeton; Andrew Cherniak; Matthew L. Meyerson, MD, PhD; Mark Awad, MD PhD; Tumor and Stromal Cell Biology Bioinformatics; Biomarkers; Checkpoint blockade; Solid tumors
O78 Identification of breast cancer neoantigens exposed by radiation therapy Claire Lhuillier, PhD; Nils Rudqvist; Takahiro Yamazaki, PhD; Lorenzo Galluzzi; Sandra Demaria, MD; Tumor and Stromal Cell Biology Neoantigens; Radiotherapy; Solid tumors; Tumor antigens; Vaccine
O79 Mapping the spatial architecture of acute myeloid leukemia in the bone marrow microenvironment by multiplexed ion beam imaging Xavier Rovira-Clave, PhD; Sizun Jiang, PhD; Xavier Rovira-Clave, PhD; Yunhao Bai, BS; Bokai Zhu; Marc Bosse, PhD; Michael Angelo, MD, PhD; Yara Banz, MD, PhD; Christian M. Schürch, MD, PhD; Garry P. Nolan, PhD; Tumor and Stromal Cell Biology B cell; Checkpoint blockade; Immune monitoring; Leukemia/Lymphoma; Myeloid cells; Proteomics; T cell; Tumor evasion; Tumor microenvironment; Tumor stroma
O80 Atlas of clinically-distinct cell states and cellular ecosystems across human solid tumors Bogdan Luca; Ash Alizadeh; Max Diehn; Aaron Newman; Andrew Gentles, PhD; Chloé Steen; Andrew Gentles, PhD; Tumor and Stromal Cell Biology Bioinformatics; Biomarkers; Gene expression; Immune contexture; Systems biology; Tumor infiltrating lymphocytes (TILs); Tumor microenvironment; Tumor stroma
P834 The actin regulatory protein hMENA is a key player in the paracrine TGF-β mediated crosstalk between tumor cells and cancer associated fibroblasts Paola Nistico', MD; Roberta Melchionna; Paola Trono; Francesca Di Modugno, PhD; Anna Di Carlo; Sheila Spada, PhD; Giuliana Falasca; Isabella Sperduti; Barbara Antoniani; Daniel D'Andrea; Paolo Visca; Gian Luca Grazi; Francesco Facciolo; Aldo Scarpa; Paola Nistico', MD; Tumor and Stromal Cell Biology Solid tumors; Tumor microenvironment; Tumor stroma
P835 The role of sialylation in stromal cell mediated immunosuppression in the colorectal tumour microenvironment Aideen E. Ryan, PhD; Hannah Egan, BSC; Kevin Lynch, PhD; Niamh Leonard, MSc; Michael O; Laurence J. Egan, MD; Thomas Ritter; Oliver Treacy, PhD; Aideen E. Ryan, PhD; Tumor and Stromal Cell Biology Immune suppression; Inflammation; Monocyte/Macrophage; Solid tumors; T cell; Tumor stroma
P836 Immunopathological properties of the fibroblastic niche for cancer stem cells and the niche-targeted immunotherapy Toshihiko Torigoe, MD, PhD; Yoshihiko Hirohashi, MD, PhD; Toshihiko Torigoe, MD, PhD; Tumor and Stromal Cell Biology Stem cell/cancer-initiating cell; Solid tumors; Tumor antigens; Tumor microenvironment; Tumor stroma
P837 Roles of nitric oxide synthase and cyclooxygenase inhibition in potentiating immune response in murine models of 4T1 mammary tumor Veena Somasundaram, PhD; Anne C. Gilmore; Debashree Basudhar; Erika Palmieri; David A. Scheiblin; William F. Heinz; Robert Cheng; Lisa Ridnour, PhD; Stephen J. Lockett; Daniel W. McVicar, PhD; David A. Wink; Tumor and Stromal Cell Biology Biomarkers; Inflammation; Myeloid cells; Tumor microenvironment
P838 Disrupting hypoxic tumor niches to sensitize pancreatic cancer to immunotherapy Arthur J. Liu, BS; Michael A. Curran, PhD; Tumor and Stromal Cell Biology Angiogenesis; Immune suppression; Solid tumors; Tumor infiltrating lymphocytes (TILs); Tumor microenvironment
P839 DNA demethylating agent sensitizes lung cancer cells to immune attack of γδ T cells Rueyhung R. Weng, PhD; Chien-Ting Lin; Hsuan-Hsuan Lu; Chong-Jen Yu; Hsing-Chen Tsai; Tumor and Stromal Cell Biology Chemotherapy; Proteomics; Solid tumors; T cell; Tumor antigens
P840 Characterization of syngeneic tumor models and their microenvironment for immunotherapeutic approaches Marco Carretta, PhD; Marie Louise Thorseth; Dennis A. Agardy; Silvia Redondo Garcia; Anne Mette Hvid Larsen, M.Sc; Dorota E. Kuczek, MSc; Daniel H. Madsen; Tumor and Stromal Cell Biology Solid tumors; Tumor microenvironment
P841 NCG/CRL as a novel (Charles River) humanized mouse model for pre-clinical oncology studies: immunophenotypic characterization and performance monitoring Jenny Rowe, PhD; Christoph CE. Eberle, PhD; Jenny Rowe, PhD; Robert Mihalek, PhD; Stephen Festin; Tumor and Stromal Cell Biology Checkpoint blockade; Immune monitoring; Leukemia/Lymphoma; Myeloid cells; NK/NK T cell; Solid tumors; T cell; T cell lineages; Tumor infiltrating lymphocytes (TILs); Tumor microenvironment
P843 Oral cancers expressing Glycoprotein-A repetitions predominant (GARP) show poor prognosis Rieneke van de Ven, PhD; Jan Kloosterman, Bsc; Irene H. Nauta, M.Sc; Sonja H. Ganzevles, BSc; Elisabeth Bloemena, Prof. Dr.; C. René Leemans, MD, PhD; Ruud H. Brakenhoff, MD, PhD; Tumor and Stromal Cell Biology Biomarkers; Immune suppression; Immune tolerance; Solid tumors; Tumor evasion; Tumor microenvironment
P844 Investigating the immunologic landscape and tumor-specific target identification in human clear cell renal carcinoma Nivedita Chowdhury, MS; Aleksandar Obradovic; David H. Aggen, MD, PhD; Michael Johnson; Charles G. Drake, MD, PhD; Tumor and Stromal Cell Biology Neoantigens; Solid tumors; T cell; Tumor infiltrating lymphocytes (TILs); Tumor antigens; Tumor microenvironment
P845 Targeting of Lactate Dehydrogenase C and its effects on the tumor immune microenvironment: two birds with one stone Adviti Naik, PhD; Julie Decock, PhD; Aljazi M. Al-Khalifa; Tumor and Stromal Cell Biology Carcinogenesis; Cytokine; Gene expression; Immune contexture; Immune suppression; Metabolism; Solid tumors; Tumor antigens; Tumor evasion; Tumor microenvironment
P846 Tumor-infiltrating B cells control the progression of oropharyngeal squamous cell carcinoma via cell-to-cell interactions with CD8+ T cells Kamila Hladíková; Vladimír Koucký; Jan Boucek; Jan Laco; Marek Grega; Aleš Ryška; Radek Špíšek; Anna Fialová; Tumor and Stromal Cell Biology B cell; Carcinogenesis; Checkpoint blockade; Costimulation; T cell; Tumor infiltrating lymphocytes (TILs); Tumor microenvironment
P847 Macrophages-induced H19 Up-regulation Activate the miR-193b/MAPK1 Axis and Promotes Cell Aggressiveness in Hepatocellular Carcinoma Yingnan Ye; Jinpu Yu; Yingnan Ye; Tumor and Stromal Cell Biology Biomarkers; Monocyte/Macrophage; Tumor microenvironment
P848 MiR-17 Cluster Promoted M2-polarized Tumor Associated Macrophages Related Cell Aggressiveness via Inducing the Imbalance of TGF-β1 /BMP7 Pathways in Hepatocellular Carcinoma Yingnan Ye; Junya Ning; Jinpu Yu; Tumor and Stromal Cell Biology Monocyte/Macrophage; Tumor microenvironment