Abstracts

Poster Presentation Dates

All odd numbered posters will be presented on Friday, November 8, 2019, while even numbered posters will be presented on Saturday, November 9, 2019.

Posters will be on display from 7 a.m. - 8 p.m., with the presenting authors required to be at their posters during lunch (12:30 - 2 p.m. on Friday, Nov. 8, and 12:35 - 2:05 p.m. on Saturday, Nov. 9) and also during the poster reception (6:30 - 8p.m. on Friday, Nov. 8, and 7 - 8:30 p.m. on Saturday, Nov. 9).

#	Title	Authors	Category	Keywords
O66	Patient-derived microbiota germ-free mouse model for identifying mechanisms of checkpoint blockade efficacy modulation	Vyara Matson, PhD; Jessica L. Fessler, BS; Yuanyuan Zha, PhD; Thomas F. Gajewski, MD, PhD;	Microbiome and other environmental factors	Checkpoint blockade; Microbiome
O67	Variation in the commensal urinary microbiome is associated with response to Bacillus Calmette-Guérin (BCG) immunotherapy in early stage urothelial bladder cancer.	Randy F. Sweis, MD; Randy F. Sweis, MD; Ciro Andolfi; Jeffrey Bloodworth; Shay Golan, MD; Nimrod Barashi; Elle Hill; Ryan Werntz; Thomas F. Gajewski, MD, PhD; Gary D. Steinberg, MD;	Microbiome and other environmental factors	Biomarkers; Chemokine; Clinical study; Cytokine; Immune contexture; Microbiome; Solid tumors; Tumor microenvironment
O68	Characteristics of the microbiome form and function of complete responders to Anti-PD1 and healthy individuals implicate donor selection for clinical trial design	Md Abdul Wadud Khan, PhD; Jennifer A. Wargo, MD, MMSc; Beth Helmink, MD PhD; Elizabeth Burton; Christine N. Spencer, PhD; Jennifer L. McQuade, MD; Miles Andrews, MD, PhD; Alexandria Cogdill; Lauren E. Haydu, MS, BChe, MIPH; Reetakshi Arora; Angela L. Harris; Vanessa B. Jensen, DVM; Adrienne F. Duran, B.A.S.; Linsey Martin; Elizabeth Sirmans; Sapna Patel, MD; Tim Heffernan; Robert Jenq, MD; Michael K. Wong, MD PhD FRCPC; Jeffrey E. Gershenwald, MD; Tawbi Hussein; Isabella C. Glitza, MD, PhD; Patrick Hwu, MD; Michael Davies, MD, PhD; David Cook; Jennifer Wortman; Theresa LaVallee, PhD; Adi Diab, MD; Vancheswaran Gopalakrishnan; Md Abdul Wadud Khan, PhD;	Microbiome and other environmental factors	Bioinformatics; Biomarkers; Checkpoint blockade; Clinical study; Microbiome
O69	Helicobacter hepaticus remodels the tumor immune microenvironment and reduces colorectal tumor burden	Abigail E. Overacre-Delgoffe, PhD; Hannah Bumgarner; Ansen HP. Burr; Timothy W. Hand, PhD;	Microbiome and other environmental factors	Dendritic cell; Immune suppression; Microbiome; Regulatory T cell (Treg cell); T cell; Tumor infiltrating lymphocytes (TILs); Tumor microenvironment
P744	Physical fitness influences the composition of human T cell populations	Michael P. Gustafson, PhD; Courtney M. Wheatley-Guy, PhD; Svetlana Bornschlegl; Allan B. Dietz, PhD; Dennis A. Gastineau, MD; Emmanuel Katsanis, MD; Richard J. Simpson, PhD; Bruce D. Johnson, PhD;	Microbiome and other environmental factors	Immune monitoring; Immune suppression; T cell
P745	Tumor cell metabolism as a barrier to immunotherapy in melanoma	Ashley Menk, MS; Greg M. Delgoffe, PhD; Yana G. Najjar, MD; Ashley Menk, MS; John M. Kirkwood, MD;	Microbiome and other environmental factors	Adoptive immunotherapy; Checkpoint blockade; Metabolism; Tumor microenvironment
P746	Global metabolomics of advanced gastric cancer patients identifies signatures associated with response and clinical benefit from nivolumab	Carrie B. Brachmann, PhD; Daniel Cooper; Kari Wong; Ethan Grant; Daniel V. Catenacci, MD; David Cunningham; Jean-Philippe Metges; Eric Van Cutsem, MD, PhD; Zev Wainberg, MD; Dung Thai; Pankaj Bhargava; Emon Elboudwarej; Ondrej Podlaha; Wadud Khan; Jennifer A. Wargo, MD, MMSc; Manish Shah, MD;	Microbiome and other environmental factors	Bioinformatics; Biomarkers; Checkpoint blockade; Clinical trial; Metabolism; Microbiome; Solid tumors
P747	Leveraging the Second Genome platform to develop microbiome-derived cancer immunotherapies	Dhwani Haria; Jayamary D. Ravichandar; Lynn Yamamoto; Cheryl-Emiliane Chow; Bernat Raja; Joanna Dreux; Kareem Graham; Kathryn Iverson; Shoko Iwai; Sunit Jain; Yuliya Katlinskaya; Sabina Lau; Jina Lee; Michelle Lin; Paul Loriaux; Nicole Narayan; Erica Rutherford; Connor Skennerton; Thomas Weinmaier; Michi Wilcoxon; Yonggan Wu; Todd DeSantis; Toshihiko Takeuchi; Karim Dabbagh; Helena Kiefel, PhD;	Microbiome and other environmental factors	Microbiome; Solid tumors; Tumor microenvironment
P748	A rationally-designed consortium of human gut commensals induces IFNg+ CD8+ T cells and enhances tumor immunity	Amanda Prince, PhD; Johnny Lightcap; Amit Reddy; Sachin K. Deshmukh; Steve McClellan; Bruce L. Roberts, PhD; Rose Szabady; Arthur E. Frankel;	Microbiome and other environmental factors	Checkpoint blockade; Dendritic cell; Microbiome; T cell; Tumor infiltrating lymphocytes (TILs)
P749	Investigation of immune-microbiota interaction in lung cancer using genetically engineered mouse models	Chengcheng Jin, PhD; Tyler Jacks, PhD; Georgia Lagoudas;	Microbiome and other environmental factors	Cytokine; Granulocyte; Immune contexture; Inflammation; Myeloid cells; Microbiome; Solid tumors; Tumor microenvironment
P750	Predicting response to anti-PD1 therapy from metagenomic sequencing data with machine learning	Jan Majta, MSc; Krzysztof Odrzywolek; Agata Szymanek; Monika Majchrzak-Gorecka; Szymon Wojciechowski; Zuzanna Karwowska; Kaja Milanowska;	Microbiome and other environmental factors	Bioinformatics; Checkpoint blockade; Microbiome
P751	A targeted next generation sequencing assay to analyze and characterize the gut microbiome for health research	Anna McGeachy, PhD; David Merrill; Shrutii Sarda; Birgit Drews; Wing Lee; Heesun Shin; Janice Au-Young; Rajesh K. Gottimukkala, MS; Aren Ewing; Fiona Hyland;	Microbiome and other environmental factors	Autoimmunity; Bioinformatics; Biomarkers; Carcinogenesis; Checkpoint blockade; Immune monitoring; Inflammation; Metabolism; Microbiome
P752	Antitumor activity of neoantigen cancer vaccine delivered by DNA electroporation is driven by the microbiota	Lucia Lione; Erika Salvatori; Antonella Conforti; Gennaro Ciliberto; Luigi Aurisicchio; Fabio Palombo, PhD	Microbiome and other environmental factors	Microbiome; Neoantigens; T cell
P753	Trial in progress: A phase I study of live biotherapeutic MRx0518 in the neoadjuvant setting for patients awaiting surgical removal of solid tumours	John D. Weinberg, MD; Jonathan Krell, PhD, MRCP, MBChB, BSc;	Microbiome and other environmental factors	Clinical study; Clinical trial; Cytokine; Microbiome; Regulatory T cell (Treg cell); Solid tumors; T cell
P754	Using advanced imaging techniques to study the interactions among malignant cells, immune system, and microbiota in lung adenocarcinoma	Chen Zhao, MD; Weizhe Li; Chengcheng Jin, PhD; Tyler Jacks; Ronald N. Germain, MD, PhD;	Microbiome and other environmental factors	Solid tumors; Tumor microenvironment
P755	Microbiome spatial patterns as markers of cancer immune therapy response	Bokai Zhu, BS; Yunhao Bai, BS; Sizun Jiang, PhD; Xavier Rovira-Clave; Justin Sonnenburg; Garry Nolan;	Microbiome and other environmental factors	Immune monitoring; Microbiome