Abstracts

Poster Presentation Dates

All odd numbered posters will be presented on Friday, November 8, 2019, while even numbered posters will be presented on Saturday, November 9, 2019.

Posters will be on display from 7 a.m. - 8 p.m., with the presenting authors required to be at their posters during lunch (12:30 - 2 p.m. on Friday, Nov. 8, and 12:35 - 2:05 p.m. on Saturday, Nov. 9) and also during the poster reception (6:30 - 8p.m. on Friday, Nov. 8, and 7 - 8:30 p.m. on Saturday, Nov. 9).

#	Title	Authors	Category	Keywords
O42	Transcriptional dissection reveals antitumor role of T follicular helper cells in head and neck cancer	Anthony R. Cillo, PhD; Dario A. Vignali, PhD;	Immune Cell Biology	B cell; Bioinformatics; Biomarkers; Gene expression; T cell; T cell lineages; Tumor infiltrating lymphocytes (TILs); Tumor microenvironment
O43	Immune profiling of the tumor microenvironment in classic Hodgkin lymphoma using high-complexity mass cytometry is feasible and reveals significant multi-compartment heterogeneity between patients	El-ad David Amir, PhD; Jose C. Villasboas, MD; Kaitlyn R. McGrath, M.S.; Stephen M. Ansell, MD, PhD;	Immune Cell Biology	Bioinformatics; Immune monitoring; Systems biology; T cell; Tumor microenvironment
O44	Intratumoral CD163+ DC amplify the type 1 immune response of CD4+CD161+ T cells in HPV16-associated cancers and are associated with better survival	Chantal Duurland, PhD; Saskia Santegoets; Nikki M. Loof; Vanessa J. van Ham; Ilina Ehsan; Marij JP. Welters, PhD; Sjoerd H. van der Burg;	Immune Cell Biology	Antigen presenting cells; Cytokine; Dendritic cell; Immune contexture; Myeloid cells; T cell; Tumor infiltrating lymphocytes (TILs); Tumor microenvironment
O45	Overexpression of CD200 is a stem cell-specific mechanism of T cell evasion in AML	Shelley Herbrich, MS; Gheath Alatrash, DO, PhD; Richard E. Davis, MD; Michael A. Curran, PhD; Marina Konopleva, MD, PhD; Shelley Herbrich, MS;	Immune Cell Biology	Leukemia/Lymphoma; T cell; Tumor evasion
O46	Characterization of tumor infiltrating and post HSCT NK and T cells in human cancer patients	Sean J. Judge, MD, MS; Cordelia Dunai; Ian Sturgill; Kevin M. Stoffel, MS; Patrice Chevallier; Christelle Retière; Arta Monjazeb; Robert Canter, MD, MAS, FACS; William J. Murphy, PhD;	Immune Cell Biology	Checkpoint blockade; NK/NK T cell; Solid tumors; Surgery; T cell; Tumor microenvironment
O47	IL-35+ B cells regulates anti-tumor immune response in pancreatic cancer	Bhalchandra Mirlekar, PhD; Yuliya Pylayeva-Gupta; Bhalchandra Mirlekar, PhD;	Immune Cell Biology	B cell; Cytokine; Immune suppression; Targeted therapy; Tumor microenvironment
O48	Characterizing the anti-tumor immune response to an array of tumor cell lines expressing unique neoantigens	Christopher J. Copeland; Kim B. Nguyen, B.A.; Kim B. Nguyen, B.A.; Stefani Spranger, PhD;	Immune Cell Biology	Checkpoint blockade; Neoantigens; Solid tumors; T cell; Tumor infiltrating lymphocytes (TILs); Tumor antigens; Vaccine
O49	Chronic activation under hypoxia drives T cell differentiation to exhaustion	Nicole E. Scharping, PhD; Yiyang Wang, N/A; Ashley Menk, MS; Greg M. Delgoffe, PhD;	Immune Cell Biology	Checkpoint blockade; Coinhibition; Metabolism; Solid tumors; T cell; T cell lineages; Tumor infiltrating lymphocytes (TILs); Tumor microenvironment
O51	Sirt2 inhibition enhances anti-tumor immunity by promoting T cell metabolism	Imene Hamaidi, PhD; Lin Zhang, MD. Ph.D; Nayoung Kim, Ph.D; Min-Hsuan Wang; Cristina Iclozan, PhD; Bin Fang, PhD; Min Liu, PhD; John Koomen, PhD; Anders E. Berglund, PhD; Sean J. Yoder; Jiqiang Yao, PhD; Ben C. Creelan, MD, MS; Scott J. Antonia, MD. PhD; Sungjune Kim, MD PhD;	Immune Cell Biology	Checkpoint blockade; Clinical trial; Metabolism; T cell; Tumor infiltrating lymphocytes (TILs); Tumor evasion; Tumor microenvironment
O52	ADT-mediated IL-8 Promotes Myeloid Infiltration and Prostate Cancer Progression	Zoila A. Lopez Bujanda, MS; Michael C. Haffner, MD; Matthew G. Chaimowitz; Nivedita Chowdhury; Nicholas J. Venturini; Aleksandar Obradovic; Corey S. Hansen; Joanna Jacków; Karen S. Sfanos; Charles J. Bieberich; Paula J. Hurley; Mark J. Selby; Alan J. Korman; Angela Christiano, PhD; Angelo M. De Marzo; Charles G. Drake, MD, PhD; Zoila A. Lopez Bujanda, MS;	Immune Cell Biology	Chemokine; Granulocyte; Immune suppression; Inflammation; Myeloid cells; MDSC; Solid tumors; Tumor infiltrating lymphocytes (TILs); Tumor microenvironment
O53	Altered T-cell clonotype composition is strongly associated with differential functional orientation of colon cancer microenvironment	Jessica Roelands, Master; Peter Kuppen; Lisa Mathew; Amany Awad; Francesco M. Marincola, MD; Darawan Rinchai, PhD; Davide Bedognetti, MD, PhD; Wouter RL. Hendrickx, PhD;	Immune Cell Biology	Gene expression; Immune monitoring; T cell; Tumor infiltrating lymphocytes (TILs)
O54	Germline Genetic Variation affects the Immune Response in Cancer	Rosalyn W. Sayaman, PhD; Mohamad Saad, PhD; Vésteinn Thorsson, PhD; Younes Mokrab; Wouter RL. Hendrickx, PhD; Farshad Farshidfar; Tomas Kirchhoff, PhD; Randy F. Sweis, MD; Najeeb Syed; Oliver Bathe; Eduard Porta-Pardo; Cynthia Stretch; Donglei Hu; Scott Huntsman; Jessica Roelands, Master; Simon Shelley; Denise Wolf; Jerome Galon; Francesco M. Marincola; Michele Ceccarelli; Elad Ziv; Davide Bedognetti, MD, PhD;	Immune Cell Biology	Bioinformatics; Gene expression; Genetic polymorphism; Immune contexture; T cell; Tumor infiltrating lymphocytes (TILs); Tumor microenvironment
O55	Antigen-cross presentation promotes the development of terminally differentiated CD8 T cells in young individuals	Ardiana Moustaki, PhD; Shanta Alli, PhD; Anthony E. Zamora; Jeremy C. Crawford; Paul G. Thomas; Shannon Boi; Natalie MN. McDonald; Alberto S. Pappo; Michael A. Dyer; Elizabeth Stewart; Sara Federico; Ben Youngblood;	Immune Cell Biology	Antigen presenting cells; Checkpoint blockade; Immune suppression; Monocyte/Macrophage; Myeloid cells; Pediatric tumors; Solid tumors; T cell; Tumor infiltrating lymphocytes (TILs); Tumor microenvironment
O56	Expression of ART1, an extracellular mono ADP-ribosylase, promotes lung cancer growth and dissemination by limiting tumor infiltration of P2X7R+ CD8+ T cells and CD103+ dendritic cells	Erik Wennerberg, PhD; Clarey Hung; Amanda Valeta; Timothy E. McGraw; Sandra Demaria, MD; Brendon Stiles, MD;	Immune Cell Biology	Biomarkers; Dendritic cell; Immune suppression; T cell; Tumor infiltrating lymphocytes (TILs); Tumor evasion; Tumor microenvironment
O57	Novel dsRNA-sensing dendritic cells enhance anti-tumor immunity	Ellen Duong, Sc.B.; Stefani Spranger, PhD;	Immune Cell Biology	Antigen presenting cells; Dendritic cell; Myeloid cells; Tumor microenvironment
O58	Human tumor-infiltrating MAIT cells display hallmarks of antigen-recognition that are associated with tumor bacterial infiltration	Shamin Li, PhD; Shamin Li, PhD; Evan W. Newell, PhD;	Immune Cell Biology	Microbiome; T cell; Tumor antigens; Tumor microenvironment
O59	CD8 T-cell infiltration into renal tumors requires a supportive antigen presenting niche and is independent of PD-L1 status	Caroline S. Jansen, BS; Nataliya Prokhnevska, BS; Viraj A. Master, MD, PhD; Jennifer Carlisle, MD; Mehmet A. Bilen; Maria A. Cardenas; Scott Wilkinson, PhD; Ross Lake; Adam G. Sowalsky, PhD; Adeboye O. Osunkoya, MD; Patrick Mullane, MD; Carla Ellis; Adriana M. Reyes; Yuan Liu, PhD; Haydn T. Kissick;	Immune Cell Biology	Antigen presenting cells; Dendritic cell; Immune contexture; Immunoscore; Solid tumors; T cell; Tumor infiltrating lymphocytes (TILs); Tumor microenvironment; Tumor stroma
P542	Case of an outstanding anti-cancer immune response in a microsatellite stable metastatic colon cancer	Thomas Duhen, PhD; Carmen Ballesteros Merino, PhD; Venkatesh Rajamanickam; Brady M. Bernard, PhD; Bernard A. Fox, PhD; Eric C. Anderson, MD, PhD; Philippa H. Newell, MD;	Immune Cell Biology	Chemotherapy; Neoantigens; Solid tumors; T cell; Tumor infiltrating lymphocytes (TILs); Tumor microenvironment
P543	A transcriptional signature of exhausted CD8+ T cells predicts relapse-free outcome in ER+ breast cancer patients	Colt Egelston, PhD; Weihua Guo; Christian Avalos; Min Hui Lim; Diana L. Simons; Peter P. Lee, MD; Colt Egelston, PhD;	Immune Cell Biology	Gene expression; T cell; Tumor infiltrating lymphocytes (TILs)
P544	The generation of memory CD8 T cells is regulated by intracellular Galectin-3	Mohammad Farhad, MS; William L. Redmond, PhD; Mohammad Farhad, MS;	Immune Cell Biology	Costimulation; Cytokine; T cell
P545	Expression of retention integrins by human CD4+ T cells	Kevin Lynch, MD; Marit M. Melssen, MSc; Walter C. Olson, PhD; Craig Slingluff; Kevin Lynch, MD;	Immune Cell Biology	Cytokine; T cell
P546	Immunoprofiling myeloid-derived suppressor cells in non-small cell lung carcinomas using multiplex immunofluorescence and image analysis approaches	Edwin R. Parra, MD., PhD; Mei Jiang; Cara Haymaker, PhD; Jiexin Zhang, PhD; Tong Li; Carmen Behrens, MD; Chantale Bernatchez; Auriole Tamegnon; Renganayaki K. Pandurenga; Jack Lee, PhD; John V. Heymach; Cesar Moran, MD; Ignacio Wistuba, MD;	Immune Cell Biology	Biomarkers; Granulocyte; Immune suppression; Inflammation; Monocyte/Macrophage; MDSC; Tumor microenvironment
P547	Distinct B cell signatures and tertiary lymphoid structures are driven by two etiologies in head and neck cancer	Ayana Ruffin, MS; Anthony R. Cillo, PhD; Sayali Onkar; Sheryl R. Kunning; Robert L. Ferris, MD, PhD; Dario A. Vignali, PhD; Tullia C. Bruno, PhD;	Immune Cell Biology	B cell; Immune contexture; Tumor infiltrating lymphocytes (TILs); Tumor microenvironment
P548	Beyond a cell metabolite: Glutamate receptor signaling improves antitumor T cell immunity	Anil Shanker, PhD; Maria Teresa P. De Aquino, PhD; Thomas Hodo, MS; Roman V. Uzhachenko, PhD MD; Anil Shanker, PhD;	Immune Cell Biology	Adoptive immunotherapy; Costimulation; Immune adjuvant; Immune suppression; Solid tumors; T cell; T cell lineages; Tumor infiltrating lymphocytes (TILs); Tumor microenvironment
P549	Identifying the host immune response in adult undifferentiated pleomorphic sarcoma	Rosanna L. Wustrack, MD; Evans Shao; Ross Okimoto; Lawrence Fong, MD;	Immune Cell Biology	Solid tumors; T cell; T cell lineages; Tumor infiltrating lymphocytes (TILs); Tumor microenvironment
P550	An Immune-CRISPRomics platform enabling genome-scale and pair-wise combination in vivo T-cell function screens enables comprehensive identification of novel therapeutic targets	Isabelle F. Le Mercier, PhD; Jason J. Merkin; Sean Keegan; Conor Calnan; Anja Hohmann, PhD; Nick Colletti; Eric Fagerberg; Sol Shenker; Caroline Bullock; Christopher Wrocklage; Noah J. Tubo, PhD; Tianlei Xu; Matt Noyes; Rami Rahal; Sean Arlauckas; Aria Pearlman Morales; Frank P. Stegmeier, PhD; Louise Cadzow; Mike Schlabach, PhD; Gregory Kryukov; Micah J. Benson, PhD;	Immune Cell Biology	Solid tumors; T cell; Tumor infiltrating lymphocytes (TILs)
P551	Bone marrow infiltrating lymphocytes possess a resident memory, stem-like phenotype that may account for enhanced anti-tumor efficacy in multiple myeloma–implications for adoptive T cell therapy	Luca Biavati, MD; Megan K. Heimann, PhD candidate; Elizabeth Zawidzka; Amy Thomas; Ervin Griffin; Danielle Dillard; Bruno Paiva; Ivan M. Borrello, MD;	Immune Cell Biology	Adoptive immunotherapy; Immune monitoring; Immune tolerance; T cell; T cell lineages; Tumor evasion; Tumor microenvironment
P552	A translational platform to assess immunomodulation of the tumor microenvironment	Louise S. Brackenbury, PhD; Robert Nunan; Anna Willox; Michelle Yap; Laura McMillan; Louise Brackenbury; S. Rhiannon Jenkinson, PhD;	Immune Cell Biology	Biomarkers; Monocyte/Macrophage; Myeloid cells; NK/NK T cell; Regulatory T cell (Treg cell); T cell; Tumor infiltrating lymphocytes (TILs); Tumor evasion; Tumor microenvironment
P553	Platelets as immune suppressors in anti-cancer immune responses	Ana Micaela M. Carnaz Simoes, MSc; Morten O. Holmström, PhD; Mads H. Andersen, PhD; Per Thor Straten, PhD;	Immune Cell Biology	Immune contexture; Immune suppression; T cell; Tumor evasion
P554	Divergent fates of antigen-specific CD8+ T cell clones in mice with acute myeloid leukemia	Xiufen Chen, PhD; Blake Flood, BS; Brendan W. MacNabb; Bruce R. Blazar, MD; Justin P. Kline, MD;	Immune Cell Biology	Antigen presenting cells; Dendritic cell; Immune suppression; Immune tolerance; Leukemia/Lymphoma; T cell; Tumor infiltrating lymphocytes (TILs); Tumor antigens
P555	Neuropilin-1 Stabilizes Human Tregs in Cancer Patients Thereby Potentiating Their Suppressive Function	Christopher A. Chuckran, BS; Anthony R. Cillo, PhD; Ashwin Somasundaram, MD; Jessica Moskovitz, MD; John M. Kirkwood, MD; Francesmary Modugno, PhD; Robert P. Edwards, MD; Robert Schoen, MD; Robert L. Ferris, MD, PhD; Tullia C. Bruno, PhD; Dario A. Vignali, PhD;	Immune Cell Biology	Checkpoint blockade; Coinhibition; Costimulation; Cytokine; Immune suppression; Regulatory T cell (Treg cell); T cell; Tumor infiltrating lymphocytes (TILs); Tumor microenvironment
P556	Sex-based differences of the intratumoral immune-infiltrate.	Fabio Conforti; Laura Pala; Vincenzo Bagnardi; Eleonora Pagan; Giuseppe Viale; Tommaso De Pas, MD; Elisabetta Penacchioli; Paola Queirolo; Emilia Cocorocchio; Pier Francesco F. Ferrucci, MD; Filippo de Marinis; Adriana Albini; Richard Gelber; Aron Goldhirsch; Fabio Conforti, MD;	Immune Cell Biology	Solid tumors; Tumor microenvironment
P557	A2bR contributes to adenosine-mediated immunosuppression, which is relieved by the dual A2aR/A2bR antagonist AB928	Daniel DiRenzo, PhD; Kristen Zhang, BS; Sean Cho, PhD; Sachie Marubayashi; Dana Piovesan, MSc; Jesus Banuelos; Joanne BL. Tan, PhD; Akshata Udyavar, Ph.D; Jenna Jeffrey, PhD; Manmohan R. Leleti, PhD; Jay P. Powers, PhD; Matthew J. Walters, PhD;	Immune Cell Biology	Antigen presenting cells; Dendritic cell; Immune suppression; Monocyte/Macrophage; Myeloid cells; Tumor microenvironment
P558	Novel gene expression programs of immune-tumor-stroma identified in inflamed Head and Neck Cancer microenvironment profiling using single cell RNA sequencing (scRNAseq)	Cornelius Kürten, MD; Aditi Kulkarni; Lazar Vujanovic, PhD; Xueer Chen; Anthony R. Cillo, PhD; Xinghua Lu; Robert L. Ferris, MD, PhD;	Immune Cell Biology	Immune contexture; Regulatory T cell (Treg cell); T cell; Tumor infiltrating lymphocytes (TILs); Tumor microenvironment; Tumor stroma
P559	Metastatic osteosarcoma utilizes multiple inhibitory checkpoint molecules and immunosuppressive myeloid cells to inhibit the cytotoxic effect of tumor-infiltrating lymphocytes	John A. Ligon, MD; Teniola F. Oke; Woonyoung Choi; Gady Cojocaru; Ludmila Danilova; Megan H. Fong; Adam Levin; Daniel S. Rhee; Carol D. Morris; Nicholas Siegel; Emily HC. Hsiue; Christian F. Meyer; David J. McConkey; Robert A. Anders, MD, PhD; Drew M. Pardoll, MD, PhD; Nicolas J. Llosa, MD;	Immune Cell Biology	Checkpoint blockade; Immune suppression; Immune tolerance; Monocyte/Macrophage; Myeloid cells; MDSC; Pediatric tumors; Solid tumors; Tumor evasion; Tumor microenvironment
P560	Cancer patients can be categorized by a uniform and mutually exclusive pattern of expression of PD-1 or PD-L1 on their tumor infiltrating T lymphocytes	Séverine Mouraud; Aurelien Marabelle, MD, PhD; Séverine Mouraud;	Immune Cell Biology	Immune monitoring; Tumor infiltrating lymphocytes (TILs); Tumor microenvironment
P561	Formation and function of and CD49b+ CD8 T cells CD49a+ in a murine breast cancer model	Marit M. Melssen, MSc; Robin Lindsay; Amanda Briegel; Anthony Rodriguez; Salwador Cyranowski; Cornelis J. Melief, MD, PhD; Sjoerd H. van der Burg; Craig Slingluff, Jr; Victor Engelhard;	Immune Cell Biology	Solid tumors; T cell; T cell lineages; Tumor infiltrating lymphocytes (TILs); Tumor microenvironment; Tumor stroma
P562	BTN2A, A New Immune-checkpoint Targeting Vgamma9Vdelta2 T cell Cytotoxicity	Carla E. Cano, PhD; Christine Pasero, PhD; Aude de Gassart; Sophie Agaugué; René HOET; Emmanuel Scotet; Erwan Mortier; Agnès Quemeneur; Chirine Rafia; Antoine Briantais; Anne-Charlotte Le Floch; Daniel Olive, MD, PhD,;	Immune Cell Biology	Antibody; Leukemia/Lymphoma; Solid tumors; T cell
P563	Profiling regulatory and cytotoxic T cell relationships in the tumor microenvironment of non-small cell lung cancer FFPE samples	Bonnie Phillips, PhD; Mark Burton, HTL ASCP; Katir K. Patel, PhD; Mael Manesse, PhD; Sean R. Downing, PhD;	Immune Cell Biology	Biomarkers; Immune monitoring; Immune suppression; Regulatory T cell (Treg cell); Solid tumors; T cell; T cell lineages; Tumor infiltrating lymphocytes (TILs); Tumor microenvironment; Tumor stroma
P564	How tumor-specific CD8 T cell activation in draining lymph nodes supports the anti-tumor CD8 T cell response	Nataliya Prokhnevska, BS; Rajesh Valanparambil; Caroline S. Jansen, BS; Viraj A. Master, MD, PhD; Martin Sanda; Haydn T. Kissick;	Immune Cell Biology	Antigen presenting cells; T cell; Tumor infiltrating lymphocytes (TILs)
P565	B cells serve as primary antigen presenting cells for DNA vaccines	Ichwaku Rastogi, BE, MS; Douglas G. McNeel, MD, PhD; Ichwaku Rastogi, BE, MS;	Immune Cell Biology	Antigen presenting cells; B cell; Dendritic cell; T cell; Vaccine
P566	Does Loss of BAP-1 influences the activation of Non-canonical NFκB pathway in uveal melanoma with inflammation?	Mithalesh Kr. Singh; Lata Singh, PhD; Seema Kashyap; Neelam Pushker, MD; Seema Sen, MD; Rachna K. Meel, M.D;	Immune Cell Biology	Biomarkers; Clinical study; Cytokine; Gene expression; Inflammation; Monocyte/Macrophage; Solid tumors; Tumor infiltrating lymphocytes (TILs); Tumor evasion; Tumor microenvironment
P567	Characterizing myeloid-derived suppressor cells in the tumor microenvironment of colorectal cancer FFPE samples	Angela Vasaturo, PhD; Angela Vasaturo, PhD; Katir K. Patel, PhD; Mael Manesse, PhD; Sean R. Downing, PhD;	Immune Cell Biology	Biomarkers; Immune monitoring; Immune suppression; MDSC; Solid tumors; Tumor microenvironment; Tumor stroma
P568	Terminally exhausted CD8+ T cells potentiate the tolerogenic tumor microenvironment as functional suppressors	Paolo DA. Vignali, BA; McLane Watson, BS; Ashley Menk, MS; Nicole E. Scharping, PhD; Kristin DePeaux, BS; Greg M. Delgoffe, PhD;	Immune Cell Biology	Immune suppression; Metabolism; Solid tumors; T cell; T cell lineages; Tumor infiltrating lymphocytes (TILs); Tumor microenvironment
P569	Immune tumor microenvironment dictates clinical outcome of oropharyngeal carcinoma upon standard therapy.	Marij J. Schoenmaekers-Welters, PhD; Saskia Santegoets; Chantal Duurland; Vanessa J. van Ham; Ilina Ehsan; Sjoerd H. van der Burg, PhD;	Immune Cell Biology	Biomarkers; Cytokine; Immune contexture; Immune suppression; Inflammation; Myeloid cells; Regulatory T cell (Treg cell); Tumor infiltrating lymphocytes (TILs); Tumor antigens; Tumor microenvironment
P570	Assay the interaction of 1000s of individual T cells and antigen-presenting cells for CAR-T or TCR screening in 24hrs.	Mark White, PhD;	Immune Cell Biology	Adoptive immunotherapy; CAR T cells; Cytokine; Immune monitoring; T cell
P571	NGS evaluation of colorectal cancer reveals interferon gamma dependent expression of immune checkpoint genes and novel genes associated with immune suppression	Lai Xu; Amy Rosneberg; Lorraine Pelosof;	Immune Cell Biology	Bioinformatics; Biomarkers; Checkpoint blockade; Solid tumors; T cell; Targeted therapy; Tumor infiltrating lymphocytes (TILs); Tumor microenvironment
P572	IFNgamma-induced Nitric Oxide Cell Death is Inhibited by L-arginine Depletion in Renal Cell Carcinoma.	Arnold H. Zea, PhD; Charity F. Silvester, MD Student; Paula Datri, BS; Arnold H. Zea, PhD;	Immune Cell Biology	Costimulation; Cytokine; Immune monitoring; Immune suppression; Immune toxicity; Metabolism; Solid tumors; Targeted therapy; Tumor evasion; Tumor microenvironment
P574	Remodeling Translation Primes CD8+ T Cell Anti-Tumor Immunity	Jessica E. Thaxton, PhD, MSCR; Kiley A. Lawrence; Katie E. Hurst; Lauren Ball, PhD; Lee Leddy, MD, MsCR; Dongjun Chung, PhD;	Immune Cell Biology	Adoptive immunotherapy; Metabolism; T cell; Tumor infiltrating lymphocytes (TILs); Tumor microenvironment
P575	Targeting the Stress Response Kinase GCN2 to Restore Immunity in the Tumor Microenvironment	Lisa A. Marshall, M.S.; Buvana Ravashankar; Lavanya Adysumilli; Deepika Kaveri; Deepa Pookot; Thant Zaw; Raashi Sreenivasan; Mikhail Zibinsky; Jeffrey Jackson; Grant Shibuya; Paul Leger; Anqi Ma; Anton Shakhmin; Andrew Ng; Omar Robles; Oezcan Talay; Delia Bradford; Christophe Colas; Scott Jacobson; Jerick Sanchez; Justy Guagua; Steve Wong; Martin Brovarney; Angela Wadsworth; Goerge Katibah; Gene Cutler; David Wustrow; Paul Kassner; Dirk Brockstedt; Lisa A. Marshall, M.S.	Immune Cell Biology	Monocyte/Macrophage; Myeloid cells; MDSC; Metabolism; T cell; Tumor infiltrating lymphocytes (TILs); Tumor microenvironment
P576	Tumor-infiltrating regulatory T cell function is metabolically supported through lactate-mediated symbiosis with the tumor microenvironment	McLane Watson, BS; Paolo DA. Vignali, BA; Steven Mullet; Natalie Rittenhouse; Ashley Menk, MS; Ryan D. Whetstone, MS, PhD; Brett Morrison; Jeffrey Rothstein; Amanda Poholek; Stacy Wendell, PhD; Greg Delgoffe, PhD;	Immune Cell Biology	Immune suppression; Regulatory T cell (Treg cell); Tumor infiltrating lymphocytes (TILs); Tumor microenvironment
P577	HDACi differentially affect distinct T-cell subsets and cytokine production	Nisha Holay, BS.; Uma Giri; Carla Van Den Berg, PharMD; Gail Eckhardt, MD; Todd A. Triplett, PhD;	Immune Cell Biology	Cytokine; T cell; T cell lineages
P578	In Vitro Assessment of the Impact of Chemotherapy Agents on Immune Cell Function	Dana Banas; Dawn Stetsko; Miye Jacques; Sium Habte; Matthew Loya; Xiaodong Wang; Krishna M. Vasudevan, DVM, PhD; Laurence Menard, PhD; Julie Carman, PhD;	Immune Cell Biology	Antigen presenting cells; Chemotherapy; Dendritic cell; Immune toxicity; T cell
P579	Predictive and prognostic relevance of CD8+ tumor-infiltrating lymphocyte density combined with PD-L1 expression in locally advanced rectal cancer patients receiving preoperative chemoradiotherapy	Changhoon Song, MD; Yoonjin Kwak; Hye Seung Lee; Sung-Bum Kang; Jae-Sung Kim;	Immune Cell Biology	Biomarkers; Chemotherapy; Clinical study; Radiotherapy; Tumor infiltrating lymphocytes (TILs); Tumor microenvironment
P580	Immunogenomic landscape of Neuroendocrine Prostate Cancer	Bhavneet Bhinder, MS; Olivier Elemento, PhD; Bhavneet Bhinder, MS; Himisha Beltran, MD; Alison Ferguson;	Immune Cell Biology	Bioinformatics; Checkpoint blockade; Cytokine; Gene expression; Immune contexture; Immune suppression; T cell; Tumor infiltrating lymphocytes (TILs); Tumor evasion; Tumor microenvironment
P581	Identification of prime Master Regulators for Immunologic Constant of Rejection at Pan-Cancer Scale using Network Analysis	Raghvendra Mall, PhD; Mohamad Saad, PhD; Jessica Roelands, Master; Wouter RL. Hendrickx, PhD; Michele Ceccarelli; Davide Bedognetti, MD, PhD;	Immune Cell Biology	Bioinformatics; Gene expression; Immune contexture; Immunoscore; Tumor evasion; Tumor microenvironment
P582	Characterization of abscopal effect in cryoablation-treated kidney cancer patients	Taigo Kato, MD, PhD; Motohide Uemura; Kazuma Kioytani; Norio Nonomura;	Immune Cell Biology	Gene expression; Immune monitoring; T cell
P583	Building a translational pathway using pharmacodynamic and syngeneic tumour models in conjunction with gene expression to enable the development of cancer immune therapies	Louise S. Brackenbury, PhD; Tommaso Iannitti; Louise Harvey, BSc; Robert Nunan; Louise Brackenbury; Clio Andreae, PhD, Bsc (Hons); S. Rhiannon Jenkinson, PhD;	Immune Cell Biology	Gene expression; Immune monitoring; T cell; Tumor infiltrating lymphocytes (TILs); Tumor antigens; Tumor microenvironment; Vaccine
P584	Functional cytomic targeting of PD-L1 at the surface of living cells to investigate resistance to immunotherapy in multiple myeloma	Jolene A. Bradford, MLS, SCYM(ASCP); Laura G. Rico; Jordi Juncà; Jorge Bardina; Àngel Bistué-Rovira; Michael D. Ward; Jordi Petriz;	Immune Cell Biology	Checkpoint blockade; Immune suppression; MDSC; T cell; Targeted therapy; Tumor microenvironment
P585	Extracellular matrix gene expression and cytotoxic T lymphocyte infiltration in the tumor microenvironment in non-small cell lung cancer	Na Li, PhD; Hongzhe Sun; Xin Wang; Ying Zhou; Zhifu Zhang; Anushka Dikshit, PhD; Courtney M. Anderson, PhD; Xiao-Jun Ma;	Immune Cell Biology	Cytokine; T cell; Tumor microenvironment; Tumor stroma
P586	Comprehensive immune profiling of clinical samples from subjects with advanced recurrent epithelial ovarian cancer treated with a novel T cell activating therapy, DPX-Survivac	Brennan S. Dirk, PhD; Heather Torrey, PhD; Yogesh Bramhecha, PhD; Olga Hrytsenko, PhD; Stéphan Fiset; Marianne Stanford, PhD;	Immune Cell Biology	Immune monitoring; Solid tumors; T cell; Tumor infiltrating lymphocytes (TILs); Tumor evasion; Tumor microenvironment
P587	Collagen density regulates the activity of tumor-infiltrating T cells	Dorota E. Kuczek, MSc; Anne Mette Hvid Larsen, M.Sc; Marco Carretta, PhD; Adrija Kalvisa, MSc; Majken S. Siersbæk; Ana Micaela M. Carnaz Simoes, MSc; Anne Roslind; Lars Engelholm; Marco Donia, MD, PhD; Inge Marie Svane, MD; Per t. Straten; Lars Grøntved; Daniel Hargboel Madsen; Dorota E. Kuczek, MSc;	Immune Cell Biology	Immune suppression; T cell; Tumor microenvironment; Tumor stroma
P588	Development of in vitro immune effector function assays to better approximate the in vivo behavior of biotherapeutics and cell therapies	Chris Langsdorf, BS;	Immune Cell Biology	Antibody; Leukemia/Lymphoma; Monocyte/Macrophage; NK/NK T cell; Solid tumors; T cell
P589	IL-15 deficient colon carcinomas have decreased cytolytic lymphocytes and skewed myeloid cell populations.	Kimberly S. Schluns, PhD; Chih-Chien Chou, PhD; Rosa M. Santana-Carrero; R. Eric Davis, PhD; Kimberly S. Schluns, PhD;	Immune Cell Biology	Cytokine; Gene expression; Immunoscore; Myeloid cells; MDSC; NK/NK T cell; Solid tumors; T cell; Tumor infiltrating lymphocytes (TILs)
P590	The use of in vitro T cell assays to accelerate cancer development of immunotherapy and immune checkpoint inhibitors	Amin Osmani; Thibault Jonckheere; Juliette Lamy; Thibaut Janss; Mayuko Oh; Sofie Pattijn; Thibaut Janss;	Immune Cell Biology	Antigen presenting cells; Dendritic cell; Immune suppression; Immune tolerance; Monocyte/Macrophage; Myeloid cells; MDSC; Neoantigens; Regulatory T cell (Treg cell); T cell
P591	In Vitro Functional Suppressive Bioassays for Evaluating Candidate Therapeutic Effectiveness in Immuno-Oncology	Amin Osmani; Thibaut Janss; Juliette Lamy; Thibault Jonckheere; Severine Giltaire; Sofie Pattijn; Thibaut Janss;	Immune Cell Biology	Immune suppression; Immune tolerance; Monocyte/Macrophage; Myeloid cells; MDSC; Neoantigens; Regulatory T cell (Treg cell); T cell
P592	TGFβR1 antagonism improves radiation efficacy by enhancing CXCR3 dependent tumor recruitment of CD8+ T cells	Andrew J. Gunderson, PhD; Tomoko Yamazaki, PhD; Kayla McCarty, BS; Nathaniel Fox; Michaela Phillips, BA; Alejandro Alice, PhD; Tiffany Blair; Mary McCormick, RN; Andrea Burt, RN; Iliana L. Gonzalez, BS; Mark Whiteford, MD; David O'Brien; Rehan Ahmad; Maria X. Kiely, MD; Amanda V. Hayman, MD, MPH; Rui Li, MD, PhD; Todd Crocenzi, MD; Michael J. Gough, PhD; Marka R. Crittenden, MD, PhD; Kristina H. Young, MD, PhD;	Immune Cell Biology	Chemokine; Chemotherapy; Clinical trial; Radiotherapy; Tumor infiltrating lymphocytes (TILs); Tumor microenvironment
P593	Rituximab treatment induces long lasting potentiation of degranulation responses by NK cells in non-Hodgkin lymphoma patients	Dmitry Zhigarev, MS; Alexander W. Macfarlane; Mowafaq Jillab; R. Katherine Alpaugh, PhD; Adam D. Cohen, MD; Kerry S. Campbell;	Immune Cell Biology	Antibody; Leukemia/Lymphoma; NK/NK T cell
P594	Targeting immune-suppressive myeloid cell pathways for the treatment of cancer	Jesus Banuelos; Susan J. Lee, PhD; Tim Park; Nell Narasappa, MSc; Dana Piovesan, MSc; Yu Chen; Jenna Jeffrey, PhD; Jarek Kalisiak; Kimberline Gerrick; Hema Singh; Annette Becker, PhD; Jie Chen; Sean Cho, PhD; Bryan Handlos; Akshata Udyavar, Ph.D; Steve W. Young, PhD; Jay P. Powers, PhD; Matthew J. Walters, PhD; Jo BL. Tan;	Immune Cell Biology	Antigen presenting cells; Gene expression; Granulocyte; Immune suppression; Inflammation; Monocyte/Macrophage; Myeloid cells; MDSC; Tumor microenvironment
P595	Gene editing and protein expression in innate immunity cells by electroporation	Jian Chen, PhD; George Sun;	Immune Cell Biology	Gene expression; Immune monitoring; Immune suppression; Monocyte/Macrophage; Myeloid cells; Neoantigens; NK/NK T cell; Tumor microenvironment
P596	Targeted IRAK-M degradation as a novel approach in cancer immunotherapy overcoming innate-driven immunosuppression	Kanae Gamo, MS; Naomi Kitamoto; Tomoaki Hayashi; Yoshihide Tomata; Yusuke Tominari;	Immune Cell Biology	Cytokine; Immune suppression; Immune tolerance; Monocyte/Macrophage; Myeloid cells; MDSC; Targeted therapy; TLR; Tumor evasion; Tumor microenvironment
P597	Myeloid-specific inflammasome signaling promotes tumor growth	Cara Lang; Young J. Kim, MD;	Immune Cell Biology	Checkpoint blockade; Myeloid cells; MDSC; Tumor microenvironment
P598	Glioblastoma-associated myeloid cells promote regulatory T and B-cell function via transfer of microvesicle	Catalina Lee-Chang, PhH; Aida Rashidi; Jason Miska; Peng Zhang; Katarzyna Pituch; David Hou; Irina V. Balyasnikova, PhD; Maciej Lesniak, MD;	Immune Cell Biology	B cell; Immune suppression; Monocyte/Macrophage; Solid tumors; Tumor infiltrating lymphocytes (TILs); Tumor evasion; Tumor microenvironment
P599	Unveiling tumor-associated macrophages (TAMs) heterogeneity and plasticity by a fully automated sequential chromogenic multiplex assay	Anna Martirosyan, Dr; Jacques Fieschi, PhD;	Immune Cell Biology	Biomarkers; Immune contexture; Immune suppression; Inflammation; Monocyte/Macrophage; Tumor microenvironment; Tumor stroma
P600	AL008 enhances myeloid anti-tumor function by coupling SIRPα antagonism with Fc receptor-mediated activation.	Andrew PINCETIC, PhD; Jerry Yang; Isaiah Deresa; We-Hsien Ho; Hua Long; Daniel Maslyar; Spencer Liang; Arnon Rosenthal;	Immune Cell Biology	Antibody; Checkpoint blockade; Immune suppression; Monocyte/Macrophage; Myeloid cells; Tumor microenvironment
P601	Expression of an immune checkpoint receptor VSIG4 defines new subsets of mouse peritoneal macrophages	Dariusz T. Stepniak; Kanako Lewis, PhD; Chau Nguyen; Robert Navert; Ryan Gerhart; Sonja Zahner; Castle Funatake; Homero Sepulveda; Dariusz T. Stepniak;	Immune Cell Biology	Checkpoint blockade; Monocyte/Macrophage; Myeloid cells
P602	A Distinctive Lineage Negative Cell Population Produces IL-17A in Cutaneous Squamous Cell Carcinoma	Lillian Sun, BS; Jennifer Ko, MD and PhD; Allison Vidimos, MD; Shlomo Koyfman, MD; Brian R. Gastman, MD;	Immune Cell Biology	Cytokine; Immune suppression; Inflammation; Solid tumors; Tumor infiltrating lymphocytes (TILs); Tumor stroma
P603	Deciphering immune checkpoint interactions between immune and non-immune cells in head and neck squamous cell carcinoma by single-cell RNA sequencing	Lazar Vujanovic, PhD; Aditi Kulkarni; Cornelius Kurten, MD; Patricia M. Santos, PhD; Umamaheswar Duvvuri; Seungwon Kim, MD; Anthony R. Cillo, PhD; Robert L. Ferris, MD, PhD;	Immune Cell Biology	Antigen presenting cells; Bioinformatics; Immune tolerance; Monocyte/Macrophage; Myeloid cells; Solid tumors; Tumor infiltrating lymphocytes (TILs); Tumor evasion; Tumor microenvironment; Tumor stroma
P604	Hypoxia and TGF-β1 induce tissue resident memory phenotype cells from human peripheral blood T-cells in vitro	Farah Hasan, BSc; Rebecca M. Shaw; Yulun Chiu; Junmei Wang; Cassian Yee, MD;	Immune Cell Biology	T cell; T cell lineages
P605	Severity of Cytokine Release Syndrome as a Predictor of Infections after T-cell replete Haploidentical Hematopoietic Cell Transplantation (haploHCT)	Muhammad Bilal Abid, MD, MRCP (UK); Parameswaran Hari, MBBS, MD, MRCP; Aniko Szabo; Mehdi Hamadani; Mary Beth Graham; Saurabh Chhabra;	Immune Cell Biology	Chemotherapy; Clinical study; Cytokine; Immune toxicity; Inflammation; Leukemia/Lymphoma; T cell
P606	ICOSL on human dendritic cells is critical for priming T cell responses	Deena M. Maurer, MS; Juraji Adamik, PhD; Patricia M. Santos, PhD; Jian Shi, MD; Jennifer L. Taylor, PhD; Michael R. Shurin, phD; John M. Kirkwood, MD; Walter J. Storkus, PhD; Lisa H. Butterfield, PhD;	Immune Cell Biology	Antigen presenting cells; Clinical study; Costimulation; Dendritic cell; T cell; Vaccine
P607	Tumor derived IL-6 promotes early-stage myeloid derived suppressor cells(eMDSCs) via SOCS3 deficiency-related differentiation arrest in breast cancer	Jinpu Yu; Wenwen Zhang; Jinpu Yu;	Immune Cell Biology	Immune suppression; MDSC; Tumor microenvironment
P849	Melanoma-associated vitiligo skin maintains resident memory CD8 T cells with specific TCR profiles contributing to long-term tumor protection	Jichang Han, PhD candidate; Aleksey Molodtsov; Yanding Zhao; Keisuke Shirai, MD; Mary Jo Turk; Christina V. Angeles, MD;	Immune Cell Biology	Autoimmunity; Bioinformatics; Checkpoint blockade; Clinical study; Gene expression; Immune toxicity; Solid tumors; T cell