SITC Immune Biomarkers Task Force
Due to advances in cancer immunotherapy, including positive results from clinical trials testing new agents and combinations, emerging new technologies for measuring aspects of immunity, and novel candidate biomarkers from early phase trials, the SITC Immune Biomarkers Task Force has reconvened to review the state of the art, identify current hurdles to further success and to make recommendations to the field.
Topics being addressed by individual working groups include: validation of candidate biomarkers, identification of the most promising technologies, testing of high throughput immune signatures and investigation of the pre-treatment tumor microenvironment.
Biomarkers Task Force Members
View the task force members via the links below:
Publications
Working Group White Papers
Validation of Biomarkers to Predict Response to Immunotherapy in Cancer (two-part white paper)
Journal for ImmunoTherapy of Cancer
November 2016
- Volume 1 – Pre-analytical and Analytical Validation
- Volume 2 – clinical validation and regulatory considerations
Novel Technologies and Emerging Biomarkers for Personalized Cancer Immunotherapy
Journal for ImmunoTherapy of Cancer
January 2016
Immune Monitoring Technology Primers
Multiplexed Tissue Biomarker Imaging
Journal for ImmunoTherapy of Cancer
February 2016
Protein Microarray (‘Seromics’)
Journal for ImmunoTherapy of Cancer
January 2016
nCounter® PanCancer Immune Profiling Panel
Journal for ImmunoTherapy of Cancer
December 2015
Quantitative Real-Time PCR Assisted Cell Counting (qPACC) for Epigenetic-Based Immune Cell Quantification in Blood and Tissue
Journal for ImmunoTherapy of Cancer
November 2015
Clinical Validation for Predictive Markers
Journal for ImmunoTherapy of Cancer
October 2015
Flow and Mass Cytometry
Journal for ImmunoTherapy of Cancer
September 2015
Single Cell Network Profiling (SCNP)
Journal for ImmunoTherapy of Cancer
August 2015
The Enzyme-Linked Immunospot (Elispot) and Flourospot Assay
Journal for ImmunoTherapy of Cancer
July 2015
Immunosequencing
Journal for ImmunoTherapy of Cancer
June 2015
Past Publications
Preamble to the 2015 SITC Immunotherapy Biomarkers Taskforce
Journal for ImmunoTherapy of Cancer
March 2015
SITC/iSBTc Cancer Immunotherapy Biomarkers Resource Document: Online resources and useful tools – a compass in the land of biomarker discovery
Journal of Translational Medicine
September 2011
Recommendations from the iSBTc-SITC/FDA/NCI Workshop on Immunotherapy Biomarkers
Clinical Cancer Research
May 2011
Immuno-Oncology Biomarkers 2010 and Beyond: Perspectives from the iSBTc/SITC Biomarker Taskforce
Journal of Translational Medicine
December 2010
A Systematic Approach to Biomarker Discovery; Preamble to "the iSBTc-FDA Taskforce on Immunotherapy Biomarkers"
Journal of Translational Medicine
December 2008
