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Inside this Issue:

Letter from the Editor
April Articles
March Highly Accessed Articles
JITC Awards Submit Your Research

Letter from the Editor

Dear Colleagues,

As the Editor-in-Chief of the Journal for ImmunoTherapy of Cancer (JITC), the official journal of the Society for Immunotherapy of Cancer (SITC), I am delighted to share with you the progress and new developments within the Journal. 

This is a very exciting time for the field of cancer immunotherapy, and JITC is making great strides to become the leading peer-reviewed, open-access journal of its kind in the field. Submissions to and published articles in the Journal have almost doubled since this time last year. More leaders in the field are citing noteworthy JITC articles in their own research and many are choosing to publish this research in JITC.

Due to the tremendous growth of the Journal, we are pleased to announce that JITC will soon encompass more of the cutting-edge, impactful articles that leaders in the field are reading and citing every day. Stay tuned for more information on the newest addition to the Journal: the Commentary/Editorials section led by Dr. Christian Capitini of the University of Wisconsin - Madison. Dr. Capitini is an esteemed colleague in the field concentrating on Pediatric Oncology. We are extremely excited to add him to the JITC family and expand the Journal with this new section.

The increasing number of submissions calls for additional support, so to help manage the profusion of manuscripts to JITC, the Journal will also be hiring a Managing Editor to assist the Editorial Board and help solicit insightful articles from more luminaries in the field. If you or someone you know is interested in joining the JITC team as our Managing Editor, please inquire at jitceditor@sitcancer.org.

On behalf of the Editorial Board, thank you for all you have done to help JITC as it continues on its journey to become one of the preeminent journals in the field. We have much work ahead of us, but with your help, the Journal will continue to grow and prosper.

Stay tuned for more exciting announcements to come from the Journal and the Society.

Sincerely,

Pedro J. Romero, MD
Editor-in-Chief, Journal for ImmunoTherapy of Cancer

Research Articles


Acute heart failure due to autoimmune myocarditis under pembrolizumab treatment for metastatic melanoma
Heinz Läubli, Cathrin Balmelli, Matthias Bossard, Otmar Pfister, Kathrin Glatz, and Alfred Zippelius.
Journal for ImmunoTherapy of Cancer 2015, 3:11 (21 April 2015)

From the Authors

“The report describes a case with an acute autoimmune myocarditis due to immune stimulation after treatment with pembrolizumab for metastatic uveal melanoma,” said Dr. Heinz Läubli. “This first documentation of a potentially life-threatening complication of anti-PD-1 treatment is important to all oncologists treating patients with these emerging immuno-modulatory agents.”


Bridging infectious disease vaccines with cancer immunotherapy: a role for targeted RNA based immunotherapeutics
Elias J. Sayour, Luis Sanchez-Perez, Catherine Flores and Duane A. Mitchell.
Journal for ImmunoTherapy of Cancer 2015, 3:13 (21 April 2015)

From the Authors

"Cancer immunotherapy has conventionally relied on cell-mediated immunity, while successful infectious disease vaccines have been shown to induce humoral immunity,” said Dr. Elias Sayour. “RNA based cancer vaccines are especially suited to bridge these modalities. Here we review common infectious disease vaccines and the progress in RNA cancer vaccine development including novel encapsulating strategies and safe targeting mechanisms."

Human tumor infiltrating lymphocytes cooperatively regulate prostate tumor growth in a humanized mouse model
Michael D. Roth and Airi Harui.
Journal for ImmunoTherapy of Cancer 2015, 3:12 (21 April 2015)

From the Authors

"Our humanized mouse model offers a flexible platform for reconstituting the dynamic interaction that occurs between a growing human tumor and the human immune system, hopefully providing further insight into the biology of TIL and an opportunity to test various immunotherapeutic strategies for their impact on cancer biology and growth,” said Dr. Airi Harui.

Survival with AGS-003, an autologous dendritic cell-based immunotherapy, in combination with sunitinib in unfavorable risk patients with advanced renal cell carcinoma (RCC): Phase 2 study results
Asim Amin, Arkadiusz Z. Dudek, Theodore F. Logan, Raymond S. Lance, Jeffrey M. Holzbeierlein, Jennifer J. Knox, Viraj A. Master, Sumanta K. Pal, Wilson H. Miller Jr., Lawrence I. Karsh, Irina Y. Tcherepanova, Mark A. DeBenedette, W. Lee Williams, Douglas C. Plessinger, Charles A. Nicolette, and Robert A. Figlin.
Journal for ImmunoTherapy of Cancer 2015, 3:14 (21 April 2015)

From the Authors

“AGS-003 (autologous dendritic cells loaded with patient’s own tumor mRNA) may provide a useful platform for delivery of immunotherapy safely and, in combination with Sunitinib, elicited significant improvement in overall survival for patients with intermediate and poor risk metastatic renal cell carcinoma. This is currently being validated in a phase III (ADAPT) study,” said Dr. Asim Amin.


The therapeutic promise of disrupting the PD-1/PD-L1 immune checkpoint in cancer: unleashing the CD8 T cell mediated anti-tumor activity results in significant, unprecedented clinical efficacy in various solid tumors
Emanuela Romano and Pedro Romero.
Journal for ImmunoTherapy of Cancer 2015, 3:15 (21 April 2015)

From the Authors

“Following the singling out of Cancer Immunotherapy as the scientific breakthrough of the year 2013 by Science magazine, Nature published a string of five letters in its November 27 issue of 2014,” said Dr. Pedro Romero. “Here Emanuela Romano and myself summarize the reported findings and discuss them in light of the recent progress in the field of treatment of cancer based on blocking of the immune checkpoints CTLA-4 and PD-1/PD-L1.”

March Highly Accessed Articles

Preamble to the 2015 SITC immunotherapy biomarkers taskforce
Lisa H. Butterfield, Mary L. Disis, Bernard A. Fox, Samir N. Khleif and Francesco M. Marincola.
Journal for ImmunoTherapy of Cancer
2015, 3:8 (24 March 2015)

Combination of IFNα and poly-I:C reprograms bladder cancer microenvironment for enhanced CTL attraction
Ravikumar Muthuswamy, Liwen Wang, Jamie Pitteroff, Jeffrey R. Gingrich and Pawel Kalinski.
Journal for ImmunoTherapy of Cancer 2015, 3:6 (24 March 2015)

Immune therapy of metastatic melanoma developing after allogeneic bone marrow transplant
Michael Cecchini, Mario Sznol and Stuart Seropian.
Journal for ImmunoTherapy of Cancer 2015, 3:10 (24 March 2015)

Immunotherapeutic approaches to ovarian cancer treatment
Cariad Chester, Oliver Dorigo, Jonathan S. Berek and Holbrook Kohrt.
Journal for ImmunoTherapy of Cancer 2015, 3:7 (24 March 2015)

New perspective on targeting the tumor suppressor p53 pathway in the tumor microenvironment to enhance the efficacy of immunotherapy
Gang Guo and Yan Cui.
Journal for ImmunoTherapy of Cancer 2015, 3:9 (24 March 2015)

2015 JITC Best Paper Awards: Submit Now!

SITC will once again be offering two $1,000 USD awards for the best papers submitted in the Clinical/Translational and Basic Science categories. To be eligible, papers must be published in JITC by August 18, 2015. Recipients of the award will be highlighted in various SITC communications and recognized in front of their peers at SITC's 30th Anniversary Annual Meeting & Associated Programs.

Submit your Research to JITC!

SITC Members and non-members alike are invited to submit manuscripts to the Society's official journal.

Categories

JITC Editor-in-Chief
Pedro J. Romero, MD - University of Lausanne

Section Editors
Lisa H. Butterfield, PhD - University of Pittsburgh Cancer Institute
Christian Capitini, MD - University of Wisconsin - Madison
Bernard A. Fox, PhD - Earle A. Chiles Research Institute, Providence Cancer Center
Thomas F. Gajewski, MD, PhD - University of Chicago
F. Stephen Hodi, Jr., MD - Dana-Farber Cancer Institute
Cornelis J.M. Melief, MD, PhD - ISA Therapeutics BV
Walter J. Urba, MD, PhD - Earle A. Chiles Research Institute, Providence Cancer Center

To view the full editorial board, please visit: www.immunotherapyofcancer.org/about/edboard.

Waived Article Processing Charges for SITC Members Extended into 2015!

As a thank you to our members, SITC is offering waived article processing charges extended throughout 2015 (a $2,500 USD savings). For your membership code, please contact the SITC office at +1(414) 271-2456.

Visit SITC Online

www.sitcancer.org About SITC Meetings Membership Support SITC

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