| P580 | Genomic portraits of immune escape mechanism in cold tumours | Venkateswar R. Addala, PhD - Research Student; Futoshi Kawamata; Stephen H. Kazakoff, PhD; Pamela Mukhopadhyay; Catherine Bond; Katia Nones; Felicity Newell; Jennifer Borowsky; Scott Wood; Conrad Leonard; Qinying Xu; Matthew E Burge; Akinobu Taketomi; Toshiya Kamiyama; Barbara Leggett, MD FRACP; John Pearson; Vicki Whitehall; Ann-Marie Patch; Nic Waddell; | Antigen presenting cells; Bioinformatics; Immune suppression; Monocyte/Macrophage; Neoantigens; T cell; Tumor evasion; Tumor microenvironment |
| P581 | Whole-genome sequencing and multi-omic analysis of immuno-oncology biomarkers using formalin-fixed, paraffin-embedded samples | Shannon T. Bailey, PhD; Wanfeng Yu, PhD; Jim Lund, PhD; Richard T. Williams; Jeffrey R. Gulcher | Bioinformatics; Biomarkers; Gene expression; Solid tumors; Systems biology |
| P582 | Implications of ARID1A deficiency on tumor microenvironment and immune landscape in non-small cell lung cancer (NSCLC) | Young Kwang Chae, MD; Pedro Viveiros, MD; Bhoomika Sukhadia, MD; Lee Chun Park, MD; Muhammad Mubbashir Sheikh, MBBS / MD; Jeffrey Chuang; | Biomarkers; Checkpoint blockade; Gene expression; Neoantigens; Solid tumors; T cell; Tumor infiltrating lymphocytes (TILs); Tumor evasion; Tumor microenvironment |
| P583 | Single cell transcriptional immune landscape of human papilloma virus positive and negative head and neck squamous cell carcinoma | Anthony R. Cillo, PhD; Tullia C. Bruno, PhD; Tracy Tabib; Zengbiao Qi; Ting Wang; Umamaheswar Duvvuri; Ryan Soose, MD; Wei Chen; Robert Lafyatis; Robert Ferris; Dario A. Vignali, PhD | Bioinformatics; Gene expression; Solid tumors; Systems biology; Tumor microenvironment |
| P584 | High DNA repair activity is associated with immune exclusion in pediatric kidney cancers | Emily Higgs, BA; Ami V. Desai, MD; Riyue Bao, PhD; Thomas F. Gajewski, MD, PhD; | Bioinformatics; Gene expression; Immune suppression; Pediatric tumors; T cell; Tumor infiltrating lymphocytes (TILs); Tumor microenvironment |
| P585 | Structured literature review and meta-analyses of the prevalence of microsatellite instability high (MSI-H) and deficient mismatch repair (dMMR) in endometrial and ovarian cancers | Maria Lorenzi; Mayur Amonkar, PhD; Jacky Zhang; Shivani Mehta; Kai-Li Liaw | Epidemiology; Solid tumors; Targeted therapy |
| P586 | Frameshift indel selectively correlates with immunotherapy outcome for advanced NSCLC | Wungki Park, MD; Lee Chun Park, MD; Vaia Florou, MD; Diana Saravia, MD; Sangmin Chang, MD; Si Wang, M.D.; Lauren Chiec; Ashkon Rahbari; Pedro Viveiros, MD; Bhoomika Sukhadia, MD; Muhammad Mubbashir Sheikh, MBBS / MD; Nisha Mohindra; Victoria Villaflor, MD; Gilberto Lopes, MD, MBA; Young Kwang Chae, MD; | Antigen presenting cells; Bioinformatics; Biomarkers; Checkpoint blockade; Clinical study; Neoantigens; Solid tumors |
| P587 | Conditional activation of immune-related pathways and prognostic significance: a pan cancer analysis | Jessica Roelands; Michele Ceccarelli; Darawan Rinchai, PhD; Sara Pai, MD, PhD; Francesco M. Marincola, MD; Lance D. Miller, MS, PhD; Peter Kuppen; Davide Bedognetti, MD, PhD; Wouter R. Hendrickx, PhD | Bioinformatics; Gene expression; Immune contexture; Immune suppression; Immune tolerance; Neoantigens; Systems biology; Tumor infiltrating lymphocytes (TILs); Tumor evasion; Tumor microenvironment |
| P588 | Deep learning of the immune synapse | John-William Sidhom, MSE; Drew M. Pardoll, MD, PhD; Alexander Baras; | Antigen presenting cells; Biomarkers; Immune monitoring; Neoantigens; T cell; Tumor infiltrating lymphocytes (TILs); Tumor antigens; Tumor microenvironment |
| P589 | Endogenous oncogene mutation-specific T cell responses in patients with clinical response to PD-1 blockade | Kellie N. Smith, PhD; Nicolas J. Llosa, MD; Valsamo Anagnostou, MD PhD; Hok Yee N. Chan, MS; Jiajia Zhang, MD, MPH; Haidan N. Guo, BS, BA; Tricia Cottrell, MD, PhD; Jarushka Naidoo, MD; Kristen Marrone, MD; Janis M. Taube, MD, MSC; Victor E. Velculescu, MD, PhD; Julie R. Brahmer, MD; Patrick Forde, MD; Drew M. Pardoll, MD, PhD; Franck Housseau, PhD | Neoantigens; Solid tumors; T cell; Tumor antigens |
| P590 | Evaluation of whole exome sequencing for quantitative immune cell type deconvolution in tumor for clinical application in oncology | Alex So, PhD; Joyee Yao, BA; Aaron Wise, PhD; Kevin Wu; Kristina Kruglyak, PhD; Sven Biike; Traci Pawlowski, PhD; Shile Zhang, PhD | B cell; Biomarkers; Checkpoint blockade; Solid tumors; T cell; Tumor infiltrating lymphocytes (TILs); Tumor antigens; Tumor microenvironment |
| P591 | Somatic alterations in PD-L1 predict response to platinum-based chemotherapy in patients with advanced prostate cancer | Panagiotis J. Vlachostergios, MD, PhD; Aileen Lee; Charlene Thomas; Priyanka Patel; Amy L. Hackett; Naureen Rashid; Ana M. Molina, MD; David M. Nanus, MD; Himisha Beltran, MD; Scott T. Tagawa, MD, MS; Panagiotis J. Vlachostergios, MD, PhD | Bioinformatics; Biomarkers; Chemotherapy; Clinical study; Gene expression; Solid tumors |
| P592 | Clonality of tumor infiltrating and peri-tumoral lymphocytes in colorectal cancers with high-microsatellite instability | Pamela M. Ward, PhD; Mihaela Campan, PhD; Katherine A. Scribner, DO; Ashley S. Hagiya, MD; Cristina Costales, MD; Michael Bask, BS; Tiffany I. Long, BS; Afsaneh Barzi, MD; Jonas Pettersson, PhD; Louis Dubeau, MD PhD | Immune contexture; Immunoscore; Solid tumors; T cell; Targeted therapy; Tumor microenvironment; Tumor stroma |
| P593 | Robust TMB values calculated from tumor-only material show correlation and precision with paired results | Victor J. Weigman, Jr.; Natalie Mola, MS | Bioinformatics; Clinical trial; Tumor antigens; Tumor evasion |
| P594 | Dynamic analysis and visualization of the interactions between tumor and the immune cell infiltration by integrating TCGA genomic- and transcriptional- data | Mingchao Xie, PhD; Bolan Linghu; Pei Zhang, PhD; Zhongwu Lai, PhD; Jonathan Dry; Benjamin Sidders | Bioinformatics; Biomarkers; Gene expression; Immune contexture; Solid tumors; Systems biology; Tumor infiltrating lymphocytes (TILs); Tumor microenvironment |
| P595 | Smoking and KRAS mutation status in lung adenocarcinomas are associated with distinct favorable immune cell contexture in the tumor microenvironment | Yuanquan Yang, MD, PhD; Qiang Hu, MD, PhD; Song Liu; Maya Khalil, MD; Grace K. Dy; | Bioinformatics; Immune contexture; Tumor microenvironment |
| P596 | Immune gene expression characterization of genomic subsets of metastatic non-squamous non-small cell lung cancer | Edwin Yau, MD, PhD; Sarabjot Pabla, MSc, PhD, BS; Sean T. Glenn, PhD; Antonios Papanicolau-Sengos, MD; Jason Zhu, MD; Matthew K. Labriola, MD; Tian Zhang, MD; Jeffrey M. Clarke, MD; Carl D. Morrison, MD, DVM; Grace K. Dy; Edwin Yau, MD, PhD; Edwin Yau, MD, PhD; | Biomarkers; Checkpoint blockade; Gene expression; Immune contexture; Targeted therapy |
