| P576 | Evaluating the importance of inhibiting HDAC6 in metastatic breast cancer to enhance the efficacy of immunotherapy | Debarati Banik, PhD; Erica Palmer, BS; Melissa Beaty, MS; Satish R. Noonepalle, PhD; Maria MG. Hernendez, BS; Prathima Vembu, MS; Alejandro Villagra, PhD | Checkpoint blockade; Chemokine; Cytokine; Monocyte/Macrophage; Solid tumors; T cell; Tumor infiltrating lymphocytes (TILs); Tumor evasion; Tumor microenvironment |
| P577 | Activation of GSK3-beta in the melanoma tumor microenvironment renders dendritic cells refractory to immune suppression and induces T cell activation and oncolysis | Marta Lopez Gonzalez, Msc.; Rieneke van de Ven, PhD; Anita Stam; Wen Dong; Victor W. van Beusechem; Tanja D. de Gruijl, PhD | Antigen presenting cells; Dendritic cell; Immune contexture; Immune suppression; Monocyte/Macrophage; Myeloid cells; Solid tumors; T cell; Tumor evasion; Tumor microenvironment |
| P578 | Application of multiplexed immunofluorescence and multispectral imaging to investigate TGFβ pathway activation of immune cell populations in human lung cancer | Carmen Ballesteros Merino, PhD; Shawn M. Jensen, PhD; Bernard A. Fox, PhD; Sebastian Marwitz; Sebastian Marwitz; | Biomarkers; Carcinogenesis; Immune contexture; Inflammation; NK/NK T cell; Solid tumors; T cell; T cell lineages; Tumor infiltrating lymphocytes (TILs); Tumor evasion; Tumor microenvironment; Tumor stroma |
| P579 | The leukocyte chemoattractant chemerin modulates PTEN and PD-L1 expression and activity via CMKLR1 in human tumors | Russell Pachynski, MD; Keith R. Rennier, PhD; Gurpal Virdi, BS; Woo Jae Shin, BA; | Antibody; Biomarkers; Checkpoint blockade; Chemokine; Gene expression; Solid tumors; T cell; Tumor evasion; Tumor microenvironment |
| O42 | LSD1 inhibition promotes CD141Hi dendritic cell differentiation in myelodysplastic syndromes | Pragya Srivastava, PhD; Kyle Wiatrowski, BS; Prashant Singh, PhD; Eduardo Cortes Gomez, MS; Jianmin Wang, PhD; Miranda Lynch, PhD; Sheila Sait, PhD; Laurie Ann Ford, BS; Brandon Martens, BS; Linda Lutgen-Dunckley, BS; Elizabeth Griffiths, MD; Michael J. Nemeth, PhD; Stephanie Tzetzo, MA; Scott I. Abrams, PhD; | Dendritic cell; Leukemia/Lymphoma |
