| P426 | Chaos-based fractal radiomic features of nodule vasculature predicts response to immunotherapy on non-contrast lung CT | Mehdi Alilou, PHD; Marjan Firouznia, PHD; Pradnya Patil; Kaustav Bera, MBBS; Robert Gilkeson; Prabhakar Rajiah; Vamsidhar Velcheti, MD FACP; Anant Madabhushi, PhD; | Bioinformatics; Biomarkers; Checkpoint blockade; Solid tumors |
| P427 | Novel immune competent murine glioblastoma models derived from Nestin-CreERT2 QuakingL/L; P53L/L; PTENL/L mice | Chao-Hsien Chen, MD; Renee Chin, MS; Genevieve P. Hartley, PhD; Takashi Shingu, PhD; David Hong, MD; Jian Hu, PhD; Michael A. Curran, PhD; | Checkpoint blockade; Monocyte/Macrophage; Myeloid cells; Regulatory T cell (Treg cell); T cell; Tumor microenvironment |
| P428 | Spatially-resolved, high-plex digital profiling enables characterization of complex immune biology of the colorectal cancer microenvironment | Sarah E. Church; Chris Merritt, PhD; Andrew M. White, BSc; Douglas Hinerfeld, PhD; Dan Zollinger; Giang Ong, MS; Kristi Barker, MS; Sarah Warren, PhD; Joseph M. Beechem, PhD | Biomarkers; Gene expression; Immune contexture; Systems biology; T cell; Tumor infiltrating lymphocytes (TILs); Tumor evasion; Tumor microenvironment; Tumor stroma |
| P429 | Integrative spatially-resolved, high-plex digital profiling enables characterization of complex immune biology in the tumor microenvironment of mesothelioma | Carmen Ballesteros Merino, PhD; Moritz Widmaier, PhD; Sarah E. Church; Thomas Herz, PhD; Alexei Budco, MSC; Dasa Medrikova, PhD; Ivan Kanchev, PhD; Andrew M. White, BSc; Douglas Hinerfeld, PhD; Shawn M. Jensen, PhD; John R. Handy, MD; Rachel E. Sanborn, MD; Carlo B. Bifulco, MD; Sarah Warren, PhD; Joseph M. Beechem, PhD; Bernard A. Fox, PhD | Bioinformatics; Biomarkers; Immune contexture; Immune monitoring; Immune suppression; Monocyte/Macrophage; Systems biology; T cell; Tumor infiltrating lymphocytes (TILs); Tumor evasion; Tumor microenvironment; Tumor stroma |
| P430 | Radiomic texture features from MR perfusion images predicts pseudoprogression from true progression in glioblastoma patients: A multi-institutional study | Nabil A. Elshafeey; Aikaterini Kotrotsou; Srishti Abrol; Islam Hassan; Ahmed Hassan; Kamel El Salek, MD; Fanny E. Moron; Meng Law; Pascal O. Zinn; Rivka Colen, MD; | Bioinformatics; Biomarkers; Clinical study; Solid tumors |
| P431 | Radiomic Analysis differentiates between True Progression and Pseudo-progression in Glioblastoma patients: A large scale multi-institutional study | Srishti Abrol; Aikaterini Kotrotsou; Nabil A. Elshafeey; Islam Hassan; Ahmed Hassan; Tagwa Idris, MD; Kamel El Salek, MD; Ahmed Elakkad, MD; Kristin Alfaro-Munoz; Shiao-Pei Weathers; Fanny E. Moron; John F. deGroot; Meng Law; Rivka Colen, MD | Bioinformatics; Biomarkers; Solid tumors |
| P432 | High tumor mutation burden (Hypermutation) in gliomas exhibit a unique predictive radiomic signature | Islam Hassan; Aikaterini Kotrotsou; Carlos Kamiya Matsuoka; Kristin Alfaro-Munoz; Nabil A. Elshafeey; Nancy Elshafeey; Pascal O. Zinn; John F. deGroot; Rivka Colen, MD; | Bioinformatics; Biomarkers; Checkpoint blockade; Clinical study; Clinical trial; Solid tumors |
| P433 | Advances in multiplex fluorescence immunohistochemistry: 9 color imaging; whole slide multispectral | Carla Coltharp, PhD; Yi Zheng, PhD; Rachel Schaefer; Ryan Dilworth, PhD; Linying Liu; Chichung Wang; Kristin Roman, MS; Clifford C. Hoyt, MS; Peter Miller, MS; | Biomarkers; Immune suppression; Solid tumors; Systems biology; T cell; Tumor infiltrating lymphocytes (TILs); Tumor antigens; Tumor microenvironment; Tumor stroma |
| P434 | Mathematical modeling of CAR T cell therapy outcomes to develop design specifications for CAR T cell engineering | Amritava Das, PhD; Rachel R. Grosser, undergraduate; Ambar C. Velazquez Albino, BS Student; Krishanu -. Saha; Christian M. Capitini, MD; Amritava Das, PhD; | Adoptive immunotherapy; CAR T cells; T cell; T cell lineages |
| P435 | Image-based analysis of the myeloid cell landscape in the 3D co-culture with tumor cells | Gera Goverse, PhD; Kuan Yan, PhD; Lars Geulen; Paul Vink, BS; Leo Price; Lidia Daszkiewicz, PhD | Antigen presenting cells; Checkpoint blockade; Dendritic cell; Immune suppression; Monocyte/Macrophage; Myeloid cells; MDSC; Tumor infiltrating lymphocytes (TILs); TLR; Tumor evasion; Tumor microenvironment |
| P436 | Image analysis simulations of needle biopsy tumor specimens to investigate CD8+ TIL heterogeneity | Thomas Herz, PhD; Victor Matvienko; Tobias Wiestler, PhD; Rene Korn, PhD; Keith E. Steele, DVM, PhD | Bioinformatics; Solid tumors; Tumor infiltrating lymphocytes (TILs) |
| P437 | In vivo synergistic effect of checkpoint blockade and radiation therapy against chordomas in a humanized mouse model | Wataru Ishida, MD; Kyle L. McCormick, B.A.; Aayushi Mahajan, M.S.; Eric M. Feldstein, B.S.; Michael Lim, MD; Jeffrey N. Bruce; Peter Canoll, MD PhD; Sheng-fu L. Lo, M.D.; | Antibody; Checkpoint blockade; Cytokine; Immune tolerance; Radiotherapy; Solid tumors; Tumor infiltrating lymphocytes (TILs); Tumor microenvironment |
| P438 | Effect of CD3 affinity and normal tissue expression on the biodistribution and tumor targeting of MUC16xCD3 bispecific antibodies in MUC16 and CD3 humanized mice | Marcus P. Kelly, PhD; Alison Crawford, PhD; Jason T. Giurleo, PhD; Richard Tavaré, PhD; Sosina Makonnen; Carlos Hickey; Makenzie Danton; Cody Arnold; Lauric Haber; Eric Smith, PhD; Dangshe Ma; William Olson, PhD; Gavin Thurston, PhD; Jessica R. Kirshner, PhD | Antibody; Targeted therapy; Tumor antigens |
| P439 | A novel high-throughput, high-content real-time imaging platform to assess immunogenic cell killing activity of immunotherapeutic agents using patient-derived tumor samples. | Melanie Mediavilla-Varela, PhD; Melba Marie Page, Ph.D.; Jenny Kreahling, PhD; Soner Altiok, MD, PhD | Biomarkers; Immune monitoring; Immunoscore; Regulatory T cell (Treg cell); T cell; Tumor infiltrating lymphocytes (TILs); Tumor antigens; Tumor microenvironment; Tumor stroma |
| P440 | Open-source digital image analysis of whole-slide multiplex immunohistochemistry | Nikhil Lonberg, HSDG; Carmen Ballesteros Merino, PhD; Shawn M. Jensen, PhD; Bernard A. Fox, PhD; | Bioinformatics; Biomarkers; Solid tumors; Tumor microenvironment; Tumor stroma |
| P442 | Automated quantification of whole-slide multispectral immunofluorescence images to identify spatial expression patterns in the lung cancer microenvironment | Lorenz Rognoni, PhD; Vinay Pawar, PhD; Tze Heng Tan, MSc, PhD, Dipl.Ing.; Felix Segerer, PhD; Philip Wortmann, PhD; Sara Batelli, PhD; Pierre Bonneau; Andrew Fisher, PhD; Gayathri Mohankumar, MS; David Chain, PhD; Michael Surace, PhD; Keith E. Steele, DVM, PhD; Jaime Rodriguez-Canales, MD | Immune contexture; Inflammation; Solid tumors; T cell; T cell lineages; Tumor infiltrating lymphocytes (TILs); Tumor microenvironment; Tumor stroma |
| P443 | Haplotype human immune system (HIS) modeling and co-engraftment of PDX: ImmunoGraft® platform for evaluation of pharmacodynamics of Immuno Oncology therapeutics | Bhavana Verma, PhD; Maria Mancini, PhD; Angela M. Davies, MD; David Sidransky, MD; Amy Wesa, PhD; Neal Goodwin, PhD | Checkpoint blockade; Myeloid cells; Solid tumors; T cell; T cell lineages; Tumor infiltrating lymphocytes (TILs) |
| P444 | Autologous human immune system (HIS) ImmunoGraft®: Mobilized peripheral blood (MPB) derived CD34 engraftment and lineage development | Bhavana Verma, PhD; Georgia Z. Chen, PhD; Edmund K. Waller, MD, PhD, FACP; Neal Goodwin, PhD; Angela M. Davies, MD; Amy Wesa, PhD; Nabil F. Saba, MD | Myeloid cells; Stem cell/cancer-initiating cell; T cell; T cell lineages |
| P445 | Human CD33+ myeloid cells support metastatic colonization in a humanized mouse model of melanoma | Jan Martinek, PhD; Chun I. Yu, PhD; Te-Chia Wu; Kyung In. Kim; Elaheh Ahmadzadeh, PhD; Rick Maser; Florentina Marches; Patrick Metang; Pierre Authie; Hannah Brookes; Joshy George, Ph.D.; Jacques Banchereau; A. Karolina Palucka, MD, PhD | Myeloid cells; Tumor evasion; Tumor microenvironment |
| P446 | Using monocytes to instill brain tumors with TILs | Meenakshi Shanmugasundaram; Anna Zal; Shouhao Zhou; Amy B. Heimberger, MD; Tomasz Zal, PhD; Felix Nwajei, PhD | Adoptive immunotherapy; Chemokine; Dendritic cell; Monocyte/Macrophage; Myeloid cells; Solid tumors; Tumor infiltrating lymphocytes (TILs); Tumor microenvironment |
