| P195 | Transcriptomic profiling of specific populations of T-cells in Acute Myeloid Leukemia | Milad Abolhalaj, MSc; Henrik Lilljebjörn; Carl Sandén; Karin Hägerbrand; Peter Ellmark, PhD; Carl Borrebaeck; Thoas Fioretos; Kristina Lundberg, PhD; | Biomarkers; Gene expression; Leukemia/Lymphoma; Regulatory T cell (Treg cell); T cell |
| P196 | Comparison of culture media for in citro T cell assays and expansion | PONNI ANANDAKUMAR; Anne Lodge, PhD; Benjamin A. Tjoa, Ph. D.; | Adoptive immunotherapy; Antigen presenting cells; Biomarkers; CAR T cells; Chemokine; Cytokine; Metabolism; T cell; Tumor antigens |
| P197 | Modulating hexokinase 2 as a novel approach for simultaneous targeting of the tumor and its immunosuppressive microenvironment | Vered Behar, PhD; Reut Yosef, PhD; Eyal Dor-On, PhD; Nofar Amsalem, MSc; Yuval Ariel, MSc; Oren M. Becker, PhD | Immune suppression; Monocyte/Macrophage; Metabolism; Solid tumors; Targeted therapy; Tumor microenvironment |
| P198 | IDH1-R132H, a rate determining mutation in the timeline of anaplastic astrocytoma | Jonathan W. Fraser, MD; Mikhail Prosniac, PhD; Larry Harshyne; David W. Andrews, MD; D. Craig Hooper, PhD; | Angiogenesis; Chemokine; Cytokine; Gene expression; Immune suppression; Monocyte/Macrophage; Myeloid cells; Metabolism; Solid tumors; Tumor evasion; Tumor microenvironment; Tumor stroma |
| P199 | Myo-inositol up-regulates PD-L1 in non-small cell lung cancer | Eileen Fung, PhD; Jane Yanagawa; Jessica Kim | Checkpoint blockade; Solid tumors; Tumor evasion |
| P200 | Cell competition and flower code regulates competitive interactions between tumor and its microenvironment | Rajan Gogna, PhD, MS, MBA; Esha Madan, PhD, MS, MBA; Masaki Nagane; Christopher Pelham; Taylor Parker; Antonio Beltran; Carlos Carvalho, MD; | Adoptive immunotherapy; Antibody; Carcinogenesis; Chemotherapy; Gene expression; Immune adjuvant; Solid tumors; Targeted therapy; Tumor antigens; Tumor microenvironment; Tumor stroma |
| P201 | Cell competition genes drive donor cell leukemia in AML patients | Rajan Gogna, PhD, MS, MBA; Esha Madan, PhD, MS, MBA; Christopher Pelham; Taylor Parker; | Antigen presenting cells; Biomarkers; Chemotherapy; Gene expression; Immune suppression; Leukemia/Lymphoma; MDSC; Stem cell/cancer-initiating cell; Targeted therapy; Tumor microenvironment; Tumor stroma |
| P202 | Targeting the stress response kinase GCN2 to restore immunity in the tumor microenvironment | Lisa A. Marshall; Buvana Ravishankar; Lavanya Adusumilli; Mikhail Zibinsky, PhD; Deepa Pookot; Emily Huang; Oezcan Talay, PhD; Silpa Suthram; Jeffrey Jackson; Grant Shibuya; Akinori Okano; Paul Leger; Scott Jacobson, BS; Steve Wong; Sherra Johnson; Parcharee Tivitmahaisoon; Angela Wadsworth, BA; Jerick Sanchez; Martin Brovarney; David Chian, BA; Abood Okal, PhD; Delia Bradford; Christophe Colas; Andrea Kim; Gene Cutler, PhD; Jacob Schwartz; David J. Wustrow, PhD; Paul D. Kassner, PhD; Dirk Brockstedt; | Immune suppression; Immune tolerance; Myeloid cells; MDSC; Metabolism; T cell; Tumor microenvironment |
| P203 | Immunomodulatory effects through inhibition of monocarboxylate transporters in melanoma | Satish R. Noonepalle, PhD; Jennifer Kim, PhD; Namratta Manhas, PhD; Sophiya Ephrame, BS; Erica Palmer, BS; Melissa Hadley, MS; Vincent Sandanayaka, PhD; Alejandro Villagra, PhD | Checkpoint blockade; Costimulation; Cytokine; Immune suppression; Metabolism; NK/NK T cell; Solid tumors; T cell; Tumor evasion; Tumor microenvironment |
| P204 | Characterization of novel dual A2A_A2B adenosine receptor antagonists for cancer immunotherapy | Mateusz Nowak; Michal Galezowski; Paulina Wegrzyn; Aneta Bobowska; Katarzyna Dziedzic; Joanna Szeremeta-Spisak; Marcin Nowogrodzki; Grzegorz Satala; Alicja Obara; Iwona Lozinska; Marcelina Dudek; Anita Janiga; Jacek Reus; Marek Wronowski; Magdalena Zastawna; Grzegorz Statkiewicz; Maciej Rogacki; Mateusz Swirski; Jakub Woyciechowski; Magdalena Ziembik; Karolina Grycuk; Foteini Soukou; Agnieszka Adamus; Karolina Wiatrowska; Natalia Lewandowska; Aniela Golas; Olga Pierzchala; Roderick Porter; Krzysztof Brzozka; Mateusz Nowak | Immune suppression; Metabolism; Tumor evasion; Tumor microenvironment |
| P205 | Preclinical and initial phase I clinical characterization of CPI-006: an anti-CD73 monoclonal antibody with unique immunostimulatory activity | Emily C. Piccione, PhD; Andrew Hotson, PhD; Glen Mikesell, BS; Barbara Daine-Matsuoka, BS; Chunyan Gu; Trang Dao-Pick; Craig M. Hill, PhD; Antonett Madriaga; Jennifer Rudnick; Liang Liu; W B. Jones; Linda Hammerich, PhD; Joshua Brody, MD; Ginna Laport; Richard A. Miller, MD; Joseph J. Buggy; | Antibody; B cell; Clinical trial; Costimulation; Immune suppression; Metabolism; Solid tumors; Targeted therapy; Tumor infiltrating lymphocytes (TILs); Tumor microenvironment |
| P206 | Using clear cell like-RenCa and papillary like-RenCa models of Kidney Cancer to study metabolic influences on the microenvironment and metastasis | Katy Beckermann; W. K. Rathmell, MD, PhD; Bradley I. Reinfeld, BA; Peter J. Siska; Jeffrey C. Rathmell, PhD; Melissa M. Wolf; Kirsten Young; Gabriella Andrejeva, PhD; Jamie Weyandt | Immune suppression; Immune tolerance; Metabolism; Solid tumors; Tumor infiltrating lymphocytes (TILs) |
| P207 | Chronic T cell activation and metabolic stress promote the exhausted T cell state by inducing epigenetic inflexibility | Nicole E. Scharping, BS; Natalie Rittenhouse; Ashley Menk, BS; Ronal Peralta; Paolo Vignali, BA; Roderick J. O'Sullivan; Amanda Poholek; Greg M. Delgoffe, PhD; | Bioinformatics; Metabolism; Solid tumors; T cell; Tumor infiltrating lymphocytes (TILs); Tumor microenvironment |
| P208 | Metabolic reprogramming augments CAR T cell function | Yiyang Wang; Greg M. Delgoffe, PhD; Jason Lohmueller, PhD; McLane Watson, BS; Dayana B. Rivadeneira, PhD | CAR T cells; Metabolism; Tumor microenvironment |
| P209 | Antagonism of peroxisome proliferator activated receptor alpha by TPST-1120 suppresses tumor growth and stimulates anti-tumor immunity | Chan C. Whiting, PhD; Nick Stock, PhD; Davorka Messmer, PhD; Austin Chen, PhD; Lisa Rahbaek, PhD; Allison Gartung, PhD; Karin Stebbins, PhD; Traci Olafson; Alex Broadhead; Ryan Clark, PhD; Catherine Lee, MS; Chris Baccei; Dan Lorrain, PhD; Alicia Levey, PhD; Derek Metzger, BA; Amanda Enstrom, PhD; Jennifer McDevitt, PharmD, PhD; David e. Spaner, MD, PhD; Peppi Prasit, PhD; Dipak Panigrahy, MD | Antigen presenting cells; Checkpoint blockade; Chemotherapy; Cytokine; Dendritic cell; Gene expression; Immune suppression; Inflammation; Monocyte/Macrophage; Myeloid cells; MDSC; Metabolism; T cell; Tumor microenvironment |
| O9 | Endoplasmic reticulum stress-induced transcription factor C/EBP homologous protein (Chop) thwarts effector T cell activity in tumors through repression of T-bet | Yu Cao, PhD; Rosa A. Sierra; Jimena Trillo-Tinoco; Carmen Anadon; Wenjie Dai; Eslam Mohamed; Richard Klar, PhD; Sven Michel; Frank Jaschinski, PhD; Shikhar Mehrotra, PhD; Juan R. Cubillos-Ruiz; David H. Munn, MD; Jose R. Conejo-Garcia, MD, PhD; Paulo C. Rodriguez | Adoptive immunotherapy; Gene expression; Immune tolerance; T cell; Tumor infiltrating lymphocytes (TILs); Tumor microenvironment |
| O10 | Lipid accumulation in the pancreatic tumor microenvironment drives metabolic exhaustion of CD8+ T cells | Teresa Manzo, Kristin G Anderson, Boone Prentice, Aislyn Schalck, Raman Ayush, Breanna M Bates, Andrea Raimondi, Karen C Dwyer, Sara Tucci, Caterina Bartolacci, McClure Marissa, Reyzer Michelle, Jeffery M. Spraggins, N. Heath Patterson, Pier Paolo Scaglioni, Kunal Rai, Carlo Tacchetti, Richard M. Caprioli, Michael Kim, Nicholas E. Navin, Jennifer A. Wargo, Phil Greenberg, Giulio Draetta and Luigi Nezi | Adoptive immunotherapy; Metabolism; T cell; Tumor microenvironment |
| O11 | Tumor cell oxidative metabolism as a barrier to PD-1 blockade immunotherapy in melanoma | Ashley Menk, BS; Yana G. Najjar, MD; John M. Kirkwood, MD; Cindy Sander, BS; Greg M. Delgoffe, PhD | Checkpoint blockade; Metabolism; Tumor microenvironment |
| O12 | Chronic endoplasmic reticulum stress drives mitochondrial exhaustion of CD8 TILs | Kiley A. Lawrence; Jessica Thaxton, PhD, MSCR; Katie E. Hurst; Lee Leddy; Matthew Essman | Checkpoint blockade; Metabolism; T cell; Tumor infiltrating lymphocytes (TILs); Tumor microenvironment |
| O13 | Lactic acid metabolically supports the high suppressive function of tumor infiltrating regulatory T cells | McLane Watson, BS; Paolo Vignali, BA; Ryan D. Whetstone, MS, PhD; Ronal Peralta; Rahul Deshpande, PhD; Ashley Menk, BS; Nicole E. Scharping, BS; Brett Morrison, MD, PhD; Stacy Wendell, PhD; Greg M. Delgoffe, PhD | Immune suppression; Metabolism; Regulatory T cell (Treg cell); Tumor infiltrating lymphocytes (TILs); Tumor microenvironment |
| O14 | Reinvigorating TILs by hyper-oxygenation | Mateusz Rytelewski, PhD; Karine Haryutyunan; Felix Nwajei, PhD; Sergei Vinogradov, PhD; Marina Konopleva, MD, PhD; Tomasz Zal, PhD; Anna Zal | Immune suppression; Metabolism; Solid tumors; T cell; Tumor infiltrating lymphocytes (TILs); Tumor evasion; Tumor microenvironment |
